The functions of IL-23 and IL-2 on driving autoimmune effector T-helper 17 cells into the memory pool in dry eye disease

scientific article published on 23 April 2020

The functions of IL-23 and IL-2 on driving autoimmune effector T-helper 17 cells into the memory pool in dry eye disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41385-020-0289-3
P932PMC publication ID7581618
P698PubMed publication ID32327706

P50authorReza DanaQ16206939
P2093author name stringSunil K Chauhan
Chunyi Shao
Takeshi Nakao
Yihe Chen
Afsaneh Amouzegar
Nai-Wen Fan
P2860cites workMonoclonal Anti–Interleukin 23 Reverses Active Colitis in a T Cell–Mediated Model in MiceQ22250938
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivoQ24600773
Generation of pathogenic T(H)17 cells in the absence of TGF-β signallingQ24625230
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generationQ29614840
Th17 cells are long lived and retain a stem cell-like molecular signatureQ34241261
Effector CD4 T-cell transition to memory requires late cognate interactions that induce autocrine IL-2.Q34469408
TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1.Q34579440
Effector and memory CTL differentiationQ34584974
IL-23 dependent and independent stages of experimental arthritis: no clinical effect of therapeutic IL-23p19 inhibition in collagen-induced arthritisQ34612227
TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathologyQ34712326
Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineagesQ35831305
Human TH17 cells are long-lived effector memory cells.Q35937849
Interleukin-2 enhances CD4+ T cell memory by promoting the generation of IL-7R alpha-expressing cellsQ36267169
Transient enhanced IL-2R signaling early during priming rapidly amplifies development of functional CD8+ T effector-memory cellsQ36339358
Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors.Q36446889
Good for Goose, but not for Gander: IL-2 interferes with Th17 differentiationQ36765977
Chronic dry eye disease is principally mediated by effector memory Th17 cellsQ37067291
Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor alpha-chain expressionQ37387939
Dissecting the human immunologic memory for pathogensQ37846864
Origins of CD4(+) effector and central memory T cellsQ37899115
The natural history of uveitisQ38002324
Prevalence of Diagnosed Dry Eye Disease in the United States Among Adults Aged 18 Years and OlderQ38680274
The multi-subunit interleukin-2 receptorQ38686728
Th17 cells confer long-term adaptive immunity to oral mucosal Candida albicans infectionsQ39318147
Autoimmune memory T helper 17 cell function and expansion are dependent on interleukin-23.Q44344487
IFN-γ-Expressing Th17 Cells Are Required for Development of Severe Ocular Surface Autoimmunity.Q48240995
Memory CD4 T cells emerge from effector T-cell progenitors.Q48887186
Interleukin-7 and -15 maintain pathogenic memory Th17 cells in autoimmunity.Q48920345
The tachykinins substance P and hemokinin-1 favor the generation of human memory Th17 cells by inducing IL-1β, IL-23, and TNF-like 1A expression by monocytes.Q51018160
Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo.Q51887589
P921main subjecteye diseaseQ3041498
P577publication date2020-04-23
P1433published inMucosal ImmunologyQ15817743
P1476titleThe functions of IL-23 and IL-2 on driving autoimmune effector T-helper 17 cells into the memory pool in dry eye disease

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