NLRP3 Inflammasome: A Potential Alternative Therapy Target for Atherosclerosis

scientific article published on 31 March 2020

NLRP3 Inflammasome: A Potential Alternative Therapy Target for Atherosclerosis is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1155/2020/1561342
P932PMC publication ID7150718
P698PubMed publication ID32328119

P50authorYun-Lun LiQ88337221
Honglin YinQ93198161
Xinrong ZhangQ93198165
P2093author name stringYang Liu
Chao Li
P2860cites workAssociation of severity of COPD with IgE and interleukin-1betaQ85201056
Simvastatin Suppresses Interleukin Iβ Release in Human Peripheral Blood Mononuclear Cells Stimulated With Cholesterol CrystalsQ88681294
Metformin inhibited Nod-like receptor protein 3 inflammasomes activation and suppressed diabetes-accelerated atherosclerosis in apoE-/- miceQ90097498
MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibitionQ90123478
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MicroRNA-30c-5p inhibits NLRP3 inflammasome-mediated endothelial cell pyroptosis through FOXO3 down-regulation in atherosclerosisQ91010140
ER Stress Activates the NLRP3 Inflammasome: A Novel Mechanism of AtherosclerosisQ91112980
Rosmarinic acid inhibits nicotine-induced C-reactive protein generation by inhibiting NLRP3 inflammasome activation in smooth muscle cellsQ91147635
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The role of mitochondria in NLRP3 inflammasome activationQ91690807
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MicroRNA-155 promotes the ox-LDL-induced activation of NLRP3 inflammasomes via the ERK1/2 pathway in THP-1 macrophages and aggravates atherosclerosis in ApoE-/- miceQ92180952
Metformin reduced NLRP3 inflammasome activity in Ox-LDL stimulated macrophages through adenosine monophosphate activated protein kinase and protein phosphatase 2AQ92240388
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NLRP3 Inflammasome Inhibition by MCC950 Reduces Atherosclerotic Lesion Development in Apolipoprotein E-Deficient Mice-Brief Report.Q50594261
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Cereal Fiber Ameliorates High Fat/Cholesterol Diet-Induced Atherosclerosis by modulating NLRP3-Inflammasome Pathway in ApoE-/- Mice.Q52718830
Berberine Attenuates NLRP3 Inflammasome Activation in Macrophages to Reduce the Secretion of Interleukin-1β.Q52739107
Colchicine therapy in acute coronary syndrome patients acts on caspase-1 to suppress NLRP3 inflammasome monocyte activation.Q52872316
Expression of the NLRP3 Inflammasome in Carotid Atherosclerosis.Q53346950
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Cardiolipin and the Nlrp3 inflammasome.Q54635661
Atorvastatin Inhibits Inflammatory Response, Attenuates Lipid Deposition, and Improves the Stability of Vulnerable Atherosclerotic Plaques by Modulating Autophagy.Q55248758
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NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B4 in a murine model of goutQ56797722
Generation of Vascular Endothelial Cells and Hematopoietic Cells by Blastocyst ComplementationQ57292623
Inflammation in atherosclerosisQ57295305
Cathepsin B-Mediated NLRP3 Inflammasome Formation and Activation in Angiotensin II -Induced Hypertensive Mice: Role of Macrophage Digestion DysfunctionQ57785008
Critical role of caspase-1 in vascular inflammation and development of atherosclerosis in Western diet-fed apolipoprotein E-deficient miceQ57967556
Melatonin Ameliorates the Progression of Atherosclerosis via Mitophagy Activation and NLRP3 Inflammasome InhibitionQ58764473
P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis.Q64903655
Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasomeQ81925149
TRPM2 links oxidative stress to NLRP3 inflammasome activationQ24600251
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilizationQ24631966
ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis Ischemia/Reperfusion InjuryQ26748988
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Atherosclerosis — An Inflammatory DiseaseQ26776972
Reactive oxygen species at the crossroads of inflammasome and inflammationQ26830685
Gout-associated uric acid crystals activate the NALP3 inflammasomeQ28131797
Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implicationsQ28253399
CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammationQ28506984
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasomeQ29547419
Thioredoxin-interacting protein links oxidative stress to inflammasome activationQ29614471
Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expressionQ29615589
The NALP3 inflammasome is involved in the innate immune response to amyloid-betaQ29615595
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentrationQ29615596
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystalsQ29615704
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosisQ29619852
K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matterQ29620146
Vascular Smooth Muscle Cells in AtherosclerosisQ30277316
Sodium overload and water influx activate the NALP3 inflammasomeQ30497777
RNA and β-hemolysin of group B Streptococcus induce interleukin-1β (IL-1β) by activating NLRP3 inflammasomes in mouse macrophages.Q33619299
Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammationQ33644572
Macrophage death and defective inflammation resolution in atherosclerosisQ33789327
The lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activationQ34552775
CXCL16/SR-PSOX--a friend or a foe in atherosclerosis?Q34655621
The macrophage foam cell as a target for therapeutic interventionQ34986351
Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasomeQ35091448
Early hyperlipidemia promotes endothelial activation via a caspase-1-sirtuin 1 pathwayQ35224401
Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and CancerQ35815863
The Importance of NLRP3 Inflammasome in Heart FailureQ35891957
Critical role for calcium mobilization in activation of the NLRP3 inflammasomeQ36094313
Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1β secretionQ36497205
Endothelial Cell Dysfunction and the Pathobiology of AtherosclerosisQ36602763
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Monocyte-endothelial cell interactions in the development of atherosclerosisQ37116502
Sterol regulatory element binding protein 2 activation of NLRP3 inflammasome in endothelium mediates hemodynamic-induced atherosclerosis susceptibility.Q37233061
Common variants in the NLRP3 region contribute to Crohn's disease susceptibilityQ37310504
Curcumin Represses NLRP3 Inflammasome Activation via TLR4/MyD88/NF-κB and P2X7R Signaling in PMA-Induced MacrophagesQ37323341
Cholesterol-dependent cytolysins induce rapid release of mature IL-1beta from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent mannerQ37415517
The SGLT-2 Inhibitor Dapagliflozin Has a Therapeutic Effect on Atherosclerosis in Diabetic ApoE-/- MiceQ37571861
The NLRP3 inflammasome: a sensor for metabolic danger?Q37675505
Lysosomes integrate metabolic-inflammatory cross-talk in primary macrophage inflammasome activationQ37691689
The role of the NLRP3 inflammasome in the pathogenesis of airway diseaseQ37855212
Endoplasmic-reticulum calcium depletion and diseaseQ37858336
NLRP3 inflammasome as a novel player in myocardial infarctionQ38196288
Activation of NLRP3 inflammasomes contributes to hyperhomocysteinemia-aggravated inflammation and atherosclerosis in apoE-deficient miceQ38708257
POP1 might be recruiting its type-Ia interface for NLRP3-mediated PYD-PYD interaction: Insights from MD simulation.Q38735950
Atorvastatin suppresses NLRP3 inflammasome activation via TLR4/MyD88/NF-κB signaling in PMA-stimulated THP-1 monocytesQ38755032
Why Calcium? How Calcium Became the Best CommunicatorQ38909800
Human NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome activity is regulated by and potentially targetable through Bruton tyrosine kinaseQ38952745
Mitochondrial cardiolipin is required for Nlrp3 inflammasome activationQ39109101
NLRP3 inflammasome: Its regulation and involvement in atherosclerosisQ39202038
Ursodeoxycholic acid impairs atherogenesis and promotes plaque regression by cholesterol crystal dissolution in miceQ39602004
NEK7 is an essential mediator of NLRP3 activation downstream of potassium effluxQ39607181
Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release.Q40568370
Silence of NLRP3 suppresses atherosclerosis and stabilizes plaques in apolipoprotein E-deficient miceQ41009240
Bone marrow-specific caspase-1/11 deficiency inhibits atherosclerosis development in Ldlr(-/-) miceQ41147790
Correlation of NLRP3 with severity and prognosis of coronary atherosclerosis in acute coronary syndrome patientsQ41468695
Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulationQ41888241
Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activityQ42606557
The Synthetic Lignan Secoisolariciresinol Diglucoside Prevents Asbestos-Induced NLRP3 Inflammasome Activation in Murine MacrophagesQ42725585
Dietary PUFAs attenuate NLRP3 inflammasome activation via enhancing macrophage autophagy.Q42771466
Nalp3 inflammasome is activated and required for vascular smooth muscle cell calcificationQ43463230
NLRP3 inflammasomes show high expression in aorta of patients with atherosclerosisQ43612729
Boron-Based Inhibitors of the NLRP3 InflammasomeQ46106516
Dihydromyricetin inhibits NLRP3 inflammasome-dependent pyroptosis by activating the Nrf2 signaling pathway in vascular endothelial cellsQ46250426
Response to Letter Regarding Article, "Anti-inflammatory and Antiatherogenic Effects of the Inflammasome NLRP3 Inhibitor Arglabin in ApoE2.Ki Mice Fed a High-Fat Diet".Q46716701
Mangiferin inhibits endoplasmic reticulum stress-associated thioredoxin-interacting protein/NLRP3 inflammasome activation with regulation of AMPK in endothelial cellsQ46799642
Procyanidin B2 inhibits NLRP3 inflammasome activation in human vascular endothelial cellsQ46806640
Inhibition of the NLRP3 inflammasome attenuates foam cell formation of THP-1 macrophages by suppressing ox-LDL uptake and promoting cholesterol effluxQ47419772
Interleukin-1 Beta as a Target for Atherosclerosis Therapy: Biological Basis of CANTOS and BeyondQ47599422
Monocyte-Macrophages and T Cells in AtherosclerosisQ47632654
Role of NLRP3 inflammasome in the pathogenesis of cardiovascular diseasesQ47682969
Melatonin prevents endothelial cell pyroptosis via regulation of long noncoding RNA MEG3/miR-223/NLRP3 axisQ48200760
The NLRP3 inflammasome and the emerging role of colchicine to inhibit atherosclerosis-associated inflammationQ49906585
Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis.Q50130043
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P304page(s)1561342
P577publication date2020-03-31
P1433published inEvidence-based Complementary and Alternative MedicineQ5418319
P1476titleNLRP3 Inflammasome: A Potential Alternative Therapy Target for Atherosclerosis
P478volume2020