MICU1 Interacts with the D-Ring of the MCU Pore to Control Its Ca2+ Flux and Sensitivity to Ru360

scientific article published on 25 October 2018

MICU1 Interacts with the D-Ring of the MCU Pore to Control Its Ca2+ Flux and Sensitivity to Ru360 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.MOLCEL.2018.09.008
P932PMC publication ID6251499
P698PubMed publication ID30454562

P2093author name stringGyörgy Hajnóczky
Peter Várnai
György Csordás
Suresh K Joseph
Melanie Paillard
Kai-Ting Huang
P2860cites workA MICU1 Splice Variant Confers High Sensitivity to the Mitochondrial Ca2+ Uptake Machinery of Skeletal Muscle.Q50860658
MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survivalQ24301822
Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporterQ24306825
Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptakeQ24336668
MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activityQ24338031
EMRE is an essential component of the mitochondrial calcium uniporter complexQ24339589
Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complexQ28115674
The Ca(2+)-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca(2+) UptakeQ28118964
MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handlingQ28486060
The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunitQ28591017
Reconstitution of the mitochondrial calcium uniporter in yeastQ33790020
MICU1 drives glycolysis and chemoresistance in ovarian cancer.Q33815720
Oxygen-bridged dinuclear ruthenium amine complex specifically inhibits Ca2+ uptake into mitochondria in vitro and in situ in single cardiac myocytesQ34464960
Real-time imaging of the intracellular glutathione redox potential.Q34777807
MICU1 regulation of mitochondrial Ca(2+) uptake dictates survival and tissue regeneration.Q36675219
Homozygous deletion in MICU1 presenting with fatigue and lethargy in childhoodQ36794081
Architecture of the mitochondrial calcium uniporterQ36922063
MICU1 motifs define mitochondrial calcium uniporter binding and activity.Q37574309
MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium OverloadQ37651609
MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporterQ37707538
The In Vivo Biology of the Mitochondrial Calcium UniporterQ38759800
Ion and inhibitor binding of the double-ring ion selectivity filter of the mitochondrial calcium uniporterQ38888678
MICU1 Alleviates Diabetic Cardiomyopathy Through Mitochondrial Ca2+-Dependent Antioxidant ResponseQ38908286
Structure, Activity Regulation, and Role of the Mitochondrial Calcium Uniporter in Health and DiseaseQ39456070
MICU1 protects against myocardial ischemia/reperfusion injury and its control by the importer receptor Tom70Q41335224
MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporterQ41976396
Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signalingQ44468436
Systematic Identification of MCU Modulators by Orthogonal Interspecies Chemical ScreeningQ47935016
Tissue-Specific Mitochondrial Decoding of Cytoplasmic Ca2+ Signals Is Controlled by the Stoichiometry of MICU1/2 and MCU.Q49326217
P433issue4
P304page(s)778-785.e3
P577publication date2018-10-25
P1433published inMolecular CellQ3319468
P1476titleMICU1 Interacts with the D-Ring of the MCU Pore to Control Its Ca2+ Flux and Sensitivity to Ru360
P478volume72

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cites work (P2860)
Q101222461Calcium influx through the mitochondrial calcium uniporter holocomplex, MCUcx
Q92618656Crosstalk between Calcium and ROS in Pathophysiological Conditions
Q92353402Increasing Ca2+ in photoreceptor mitochondria alters metabolites, accelerates photoresponse recovery, and reveals adaptations to mitochondrial stress
Q89862880MCUB and mitochondrial calcium uptake - modeling, function, and therapeutic potential
Q64064090MICU1 and MICU2 Play an Essential Role in Mitochondrial Ca Uptake, Growth, and Infectivity of the Human Pathogen Trypanosoma cruzi
Q97643662Mitochondrial Ca2+ regulation in the etiology of heart failure: physiological and pathophysiological implications
Q104130395Mitochondrial Ca2+ in heart failure: Not enough or too much?
Q90381277Mitochondrial Calcium Uniporter Structure and Function in Different Types of Muscle Tissues in Health and Disease
Q91589499Mitochondrial calcium uniporter complex modulation in cancerogenesis
Q100509563Pharmacological inhibition of the mitochondrial Ca2+ uniporter: Relevance for pathophysiology and human therapy
Q96132235Structure and mechanism of the mitochondrial Ca2+ uniporter holocomplex
Q90150575Structure of the MICU1-MICU2 heterodimer provides insights into the gatekeeping threshold shift
Q61448042The conserved aspartate ring of MCU mediates MICU1 binding and regulation in the mitochondrial calcium uniporter complex
Q92118240Variable Assembly of EMRE and MCU Creates Functional Channels with Distinct Gatekeeping Profiles

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