Production of plant-specific flavones baicalein and scutellarein in an engineered E. coli from available phenylalanine and tyrosine

scientific article published on 26 November 2018

Production of plant-specific flavones baicalein and scutellarein in an engineered E. coli from available phenylalanine and tyrosine is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YMBEN.2018.11.008
P698PubMed publication ID30496827

P50authorIshmael MutandaQ87922533
P2093author name stringYong Wang
Jianhua Li
Kaibo Wang
Chenfei Tian
Yuhui Xia
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Overcoming heterologous protein interdependency to optimize P450-mediated Taxol precursor synthesis in Escherichia coliQ36742753
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New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and BaicalinQ37323907
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Expression and enzymatic activity of recombinant cytochrome P450 17 alpha-hydroxylase in Escherichia coliQ37539315
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Naringenin-responsive riboswitch-based fluorescent biosensor module for Escherichia coli co-cultures.Q38679159
Flavonoid baicalein suppresses adhesion, migration and invasion of MDA-MB-231 human breast cancer cellsQ39687919
Experimental and computational optimization of an Escherichia coli co-culture for the efficient production of flavonoids.Q40010168
Baicalein: A review of its anti-cancer effects and mechanisms in Hepatocellular CarcinomaQ40107306
Oxidation of flavanone to flavone with cell-free extracts from young parsley leavesQ40350972
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Flavones from Scutellaria baicalensis Georgi attenuate apoptosis and protein oxidation in neuronal cell linesQ40721535
Baicalein inhibits pancreatic cancer cell proliferation and invasion via suppression of NEDD9 expression and its downstream Akt and ERK signaling pathwaysQ41346751
Metabolic engineering of the phenylpropanoid pathway in Saccharomyces cerevisiaeQ41843126
Cloning and expression of flavone synthase II from Gerbera hybridsQ42617929
Characterization of the kaurene oxidase CYP701A3, a multifunctional cytochrome P450 from gibberellin biosynthesisQ42941519
Total synthesis of baicaleinQ43100334
Growth-rate recovery of Escherichia coli cultures carrying a multicopy plasmid, by engineering of the pentose-phosphate pathwayQ45002013
Improving cellular malonyl-CoA level in Escherichia coli via metabolic engineering.Q45950740
Engineering Escherichia coli for production of functionalized terpenoids using plant P450sQ46094196
Combinatorial biosynthesis of flavones and flavonols in Escherichia coli.Q46679217
Strain improvement of recombinant Escherichia coli for efficient production of plant flavonoidsQ46708161
Human cytomegalovirus-inhibitory flavonoids: studies on antiviral activity and mechanism of actionQ46723963
Characterization of flavonoids in the traditional Chinese herbal medicine-Huangqin by liquid chromatography coupled with electrospray ionization mass spectrometryQ47176597
Enhancement of Naringenin Biosynthesis from Tyrosine by Metabolic Engineering of Saccharomyces cerevisiae.Q47925453
Baicalein as a potent neuroprotective agent: A reviewQ50042471
Two CYP82D Enzymes Function as Flavone Hydroxylases in the Biosynthesis of Root-Specific 4'-Deoxyflavones in Scutellaria baicalensisQ50330432
An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin.Q50874452
Improved pinocembrin production in Escherichia coli by engineering fatty acid synthesis.Q50895229
Stepwise modular pathway engineering of Escherichia coli for efficient one-step production of (2S)-pinocembrin.Q51293322
Optimization of naringenin and p-coumaric acid hydroxylation using the native E. coli hydroxylase complex, HpaBC.Q51677350
Metabolic engineering of Escherichia coli for (2S)-pinocembrin production from glucose by a modular metabolic strategy.Q51843169
Biosynthesis of pinocembrin from glucose using engineered escherichia coli.Q53483499
Genome-scale metabolic network modeling results in minimal interventions that cooperatively force carbon flux towards malonyl-CoA.Q54356981
Purification and characterization of flavone synthase I, a 2-oxoglutarate-dependent desaturaseQ68574682
Protective effects of baicalein against cell damage by reactive oxygen speciesQ77422175
Enhanced flavonoid production in Streptomyces venezuelae via metabolic engineeringQ82731066
Optimization of a heterologous pathway for the production of flavonoids from glucoseQ83410228
P921main subjectEscherichia coliQ25419
P304page(s)124-133
P577publication date2018-11-26
P1433published inMetabolic EngineeringQ6822334
P1476titleProduction of plant-specific flavones baicalein and scutellarein in an engineered E. coli from available phenylalanine and tyrosine
P478volume52

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cites work (P2860)
Q93166459De novo biosynthesis of liquiritin in Saccharomyces cerevisiae
Q97425413Discovery and modification of cytochrome P450 for plant natural products biosynthesis
Q90119259Pathway-specific enzymes from bamboo and crop leaves biosynthesize anti-nociceptive C-glycosylated flavones

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