Tryptophan metabolism and its relationship with central nervous system toxicity in people living with HIV switching from efavirenz to dolutegravir

scientific article published on 26 November 2018

Tryptophan metabolism and its relationship with central nervous system toxicity in people living with HIV switching from efavirenz to dolutegravir is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S13365-018-0688-3
P932PMC publication ID6416362
P698PubMed publication ID30478800

P50authorMichael R KeeganQ93383863
P2093author name stringMark Nelson
Chris Higgs
Dietmar Fuchs
Alan Winston
Adriano Boasso
P2860cites workThe excitatory amino acid antagonist kynurenic acid administered after hypoxic-ischemia in neonatal rats offers neuroprotectionQ57982919
Simultaneous measurement of serum tryptophan and kynurenine by HPLCQ61906305
Decreased whole blood 5-hydroxytryptamine (serotonin) in AIDS patientsQ68014739
A phase IV, double-blind, multicentre, randomized, placebo-controlled, pilot study to assess the feasibility of switching individuals receiving efavirenz with continuing central nervous system adverse events to etravirineQ33448696
Anti-retroviral therapy decreases but does not normalize indoleamine 2,3-dioxygenase activity in HIV-infected patientsQ33830637
The kynurenine pathway of tryptophan catabolism, CD4+ T-cell recovery, and mortality among HIV-infected Ugandans initiating antiretroviral therapyQ34106235
Expression of the kynurenine pathway enzymes in human microglia and macrophagesQ34327818
Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neuronsQ34351574
Neuropharmacology of quinolinic and kynurenic acidsQ34728770
Tryptophan, Neurodegeneration and HIV-Associated Neurocognitive DisorderQ35366778
PharmGKB summary: Efavirenz pathway, pharmacokineticsQ35706069
Dendritic spine injury induced by the 8-hydroxy metabolite of efavirenzQ36406259
Antiretroviral neurotoxicityQ36635673
The human indoleamine 2,3-dioxygenase gene and related human genesQ36789436
How does indoleamine 2,3-dioxygenase contribute to HIV-mediated immune dysregulation.Q36789448
Assessment of the Human Kynurenine Pathway: Comparisons and Clinical Implications of Ethnic and Gender Differences in Plasma Tryptophan, Kynurenine Metabolites, and Enzyme Expressions at Baseline and After Acute Tryptophan Loading and DepletionQ37167902
Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2016 Recommendations of the International Antiviral Society-USA PanelQ37234729
Tryptophan Metabolism and Its Relationship with Depression and Cognitive Impairment Among HIV-infected IndividualsQ37372353
Psychiatric Symptoms in Patients Receiving DolutegravirQ37659135
Implications of efavirenz for neuropsychiatry: a review.Q37801927
Could antiretroviral neurotoxicity play a role in the pathogenesis of cognitive impairment in treated HIV disease?.Q38271657
Mood, food, and cognition: role of tryptophan and serotoninQ38631293
Inter-relationships between quinolinic acid, neuroactive kynurenines, neopterin and beta 2-microglobulin in cerebrospinal fluid and serum of HIV-1-infected patientsQ41094880
Increased endogenous interferon-gamma and neopterin correlate with increased degradation of tryptophan in human immunodeficiency virus type 1 infectionQ43418119
Immune activation and decreased tryptophan in patients with HIV-1 infection.Q43673162
More rapid method for simultaneous measurement of tryptophan and kynurenine by HPLC.Q43893230
Effective antiretroviral therapy reduces degradation of tryptophan in patients with HIV-1 infectionQ44128933
Indole amine deficiency in blood and cerebrospinal fluid from patients with human immunodeficiency virus infectionQ45847119
Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acidQ48634830
Kynurenic acid metabolism in the brain of HIV-1 infected patientsQ49134173
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P921main subjectefavirenzQ422645
dolutegravirQ937224
P304page(s)85-90
P577publication date2018-11-26
P1433published inJournal of NeuroVirologyQ6295640
P1476titleTryptophan metabolism and its relationship with central nervous system toxicity in people living with HIV switching from efavirenz to dolutegravir
P478volume25

Search more.