Ski drives an acute increase in MMP-9 gene expression and release in primary cardiac myofibroblasts

scientific article published on 01 November 2018

Ski drives an acute increase in MMP-9 gene expression and release in primary cardiac myofibroblasts is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.14814/PHY2.13897
P932PMC publication ID6429976
P698PubMed publication ID30488595

P2093author name stringMichael P Czubryt
Krista L Filomeno
Ian M C Dixon
Morvarid S Kavosh
Sunil G Rattan
Natalie Landry
P2860cites workSki is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptorQ22008813
NIH Image to ImageJ: 25 years of image analysisQ23319322
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Endothelial to Mesenchymal Transition (EndoMT) in the Pathogenesis of Human Fibrotic DiseasesQ26748338
c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smadsQ28138749
Direct interaction of Ski with either Smad3 or Smad4 is necessary and sufficient for Ski-mediated repression of transforming growth factor-beta signalingQ28186807
c-Jun associates with the oncoprotein Ski and suppresses Smad2 transcriptional activityQ28201147
Decreased Smad 7 expression contributes to cardiac fibrosis in the infarcted rat heartQ28581449
Focal adhesion kinase: the first ten yearsQ28609173
Focal adhesion kinase: in command and control of cell motilityQ29615192
How matrix metalloproteinases regulate cell behaviorQ29620360
Matrix metalloproteinase-2 proteolysis of calponin-1 contributes to vascular hypocontractility in endotoxemic ratsQ34243045
Neutral metalloproteinases produced by human mononuclear phagocytes. Enzyme profile, regulation, and expression during cellular developmentQ34263093
Myocardial matrix metalloproteinase-2: inside out and upside down.Q35032465
Cardiac remodeling and physical training post myocardial infarctionQ35075553
Cardiac fibroblasts: function, regulation of gene expression, and phenotypic modulationQ35220774
The transcription factor scleraxis is a critical regulator of cardiac fibroblast phenotypeQ35961854
Intracellular targets of matrix metalloproteinase-2 in cardiac disease: rationale and therapeutic approachesQ36665320
Cellular mechanisms of tissue fibrosis. 2. Contributory pathways leading to myocardial fibrosis: moving beyond collagen expressionQ36699619
Cardiac Fibrosis: The Fibroblast AwakensQ36708340
Transforming Sloan-Kettering viruses generated from the cloned v-ski oncogene by in vitro and in vivo recombinationsQ36859994
Increased secretion and expression of myostatin in skeletal muscle from extremely obese women.Q37023094
MMP-9 signaling in the left ventricle following myocardial infarctionQ37139613
Targeting matrix metalloproteinases in inflammatory conditions.Q37631616
Emerging concepts in cardiac matrix biologyQ37661389
Potential therapeutic targets for cardiac fibrosis: TGFbeta, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activationQ37764239
Tissue inhibitor of metalloproteinases (TIMPs) in heart failureQ37895982
TGF-β signaling in fibrosisQ37899212
Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart diseaseQ38040163
Cardiac intercellular communication: are myocytes and fibroblasts fair-weather friends?Q38046798
Myofibroblast-mediated mechanisms of pathological remodelling of the heartQ38064729
Activation of intracellular matrix metalloproteinase-2 by reactive oxygen-nitrogen species: Consequences and therapeutic strategies in the heartQ38150577
DNA methylation in cardiac fibrosis: new advances and perspectivesQ38228803
MMP-2 is localized to the mitochondria-associated membrane of the heartQ39038689
Angiotensin type 2 receptor stimulation ameliorates left ventricular fibrosis and dysfunction via regulation of tissue inhibitor of matrix metalloproteinase 1/matrix metalloproteinase 9 axis and transforming growth factor β1 in the rat heartQ39282244
Basic mechanisms in heart failure: the cytokine hypothesisQ41188647
Novel extracellular matrix biomarkers as predictors of adverse outcome in chronic heart failure: association between biglycan and response to statin therapy in the CORONA trialQ41632689
Antifibrotic properties of c-Ski and its regulation of cardiac myofibroblast phenotype and contractility.Q42478274
Airway mesenchymal cell death by mevalonate cascade inhibition: integration of autophagy, unfolded protein response and apoptosis focusing on Bcl2 family proteinsQ44609613
Fibroblast-specific TGF-β-Smad2/3 signaling underlies cardiac fibrosisQ47094281
Transgenic overexpression of macrophage matrix metalloproteinase-9 exacerbates age-related cardiac hypertrophy, vessel rarefaction, inflammation, and fibrosis.Q47909549
The ED-A domain enhances the capacity of fibronectin to store latent TGF-β binding protein-1 in the fibroblast matrix.Q48183721
Generating favorable growth factor and protease release profiles to enable extracellular matrix accumulation within an in vitro tissue engineering environment.Q50987512
Differential impact of mechanical unloading on structural and nonstructural components of the extracellular matrix in advanced human heart failure.Q51453829
The Oncoprotein c-Ski Functions as a Direct Antagonist of the Transforming Growth Factor-β Type I ReceptorQ54641166
The Ski-Zeb2-Meox2 pathway provides a novel mechanism for regulation of the cardiac myofibroblast phenotype.Q54703943
Cardiac fibroblast to myofibroblast differentiation in vivo and in vitro: Expression of focal adhesion components in neonatal and adult rat ventricular myofibroblastsQ58047168
Regulation of collagen synthesis by inhibitory Smad7 in cardiac myofibroblastsQ58047195
Elevation of Expression of Smads 2, 3, and 4, Decorin and TGF-βin the Chronic Phase of Myocardial Infarct Scar HealingQ58047304
Antiproliferative and antifibrotic effects of mimosine on adult cardiac fibroblasts1Previously published in abstract form: Circulation 94(8) (1996) I 355.1Q58047318
Assigning matrix metalloproteinase roles in ischaemic cardiac remodellingQ61420974
Transcriptional cofactors Ski and SnoN are major regulators of the TGF-β/Smad signaling pathway in health and diseaseQ62060038
The Oncoprotein Ski Acts as an Antagonist of Transforming Growth Factor-β Signaling by Suppressing Smad2 PhosphorylationQ73356276
Transcriptional repression by v-Ski and c-Ski mediated by a specific DNA binding siteQ74129025
Selective spatiotemporal induction of matrix metalloproteinase-2 and matrix metalloproteinase-9 transcription after myocardial infarctionQ83967433
Matrix metalloproteinase-2 stimulates collagen-I expression through phosphorylation of focal adhesion kinase in rat cardiac fibroblastsQ84852767
Differential role of TIMP2 and TIMP3 in cardiac hypertrophy, fibrosis, and diastolic dysfunctionQ87586419
Regulation of cardiac fibroblast MMP2 gene expression by scleraxisQ88641624
P433issue22
P304page(s)e13897
P577publication date2018-11-01
P1433published inPhysiological ReportsQ15716763
P1476titleSki drives an acute increase in MMP-9 gene expression and release in primary cardiac myofibroblasts
P478volume6

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Q102381776Crosstalk between the activated Slit2-Robo1 pathway and TGF-β1 signalling promotes cardiac fibrosiscites workP2860

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