Theoretical mechanism for the gastrointestinal safety of etodolac: selective sparing of cytoprotective prostaglandins

scientific article published in March 1989

Theoretical mechanism for the gastrointestinal safety of etodolac: selective sparing of cytoprotective prostaglandins is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/BF02214106
P698PubMed publication ID2525980

P2093author name stringD K Lee
D Dvornik
P2860cites workInhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugsQ29617192
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A subchronic study of the effect of etodolac on the gastric mucosal prostaglandin levels in the rat.Q41354975
Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injuryQ41682736
Temporal relationships of the anti-inflammatory effect of etodolac in the adjuvant arthritic rat.Q42110985
Gastrointestinal blood loss in arthritic patients receiving chronic dosing with etodolac and piroxicamQ43502539
Effect of etodolac in patients with moderate renal impairment compared with normal subjectsQ43652257
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Prostaglandin protection of the gastric mucosa against alcohol injury--a dynamic time-related process. Role of the mucosal proliferative zone.Q52496199
Microscopic analysis of ethanol damage to rat gastric mucosa after treatment with a prostaglandin.Q52504833
Absorption, Distribution, Metabolism, and Excretion of Naproxen in Various Laboratory Animals and Human SubjectsQ54034864
Etodolac: effect on prostaglandin concentrations in gastric mucosa of ratsQ67280472
Increased resistance of the rat gastric mucosa to hemorrhagic damage after exposure to an irritant. Role of the "mucoid cap" and prostaglandin synthesisQ68090272
Disposition and biotransformation of 14C-etodolac in manQ69992017
The effect of etodolac administration on renal function in patients with arthritisQ69993119
Etodolac compared with aspirin: an endoscopic study of the gastrointestinal tracts of normal volunteersQ69996961
Effects of nonsteroidal antiinflammatory drugs on renal function in patients with renal insufficiency and in cirrhoticsQ70019035
An endoscopic comparison of the effects of etodolac, indomethacin, ibuprofen, naproxen, and placebo on the gastrointestinal mucosaQ70032592
Effect of high-dose etodolac on renal functionQ70035999
Effect of 16,16-dimethyl prostaglandin E2 on the surface hydrophobicity of aspirin-treated canine gastric mucosaQ70043312
The metabolic disposition of etodolac in rats, dogs, and manQ70568145
Aspirin selectively inhibits prostaglandin production in human plateletsQ71062251
Gastroscopic evaluation of anti-inflammatory agentsQ71131818
Mild irritants prevent gastric necrosis through "adaptive cytoprotection" mediated by prostaglandinsQ71783549
Relationship of gastric mucosal damage induced in pigs by antiinflammatory drugs to their effects on prostaglandin productionQ72040292
Comparison in rats of the anti-inflammatory and gastric irritant effects of etodolac with several clinically effective anti-inflammatory drugsQ72768702
Bioavailability studies with etodolac in dogs and manQ72809701
Etodolac, aspirin, and gastrointestinal microbleedingQ72812179
Gastrointestinal Microbleeding Associated with the Use of Etodolac, Ibuprofen, Indomethacin, and Naproxen in Normal MalesQ72820139
P304page(s)16-24
P577publication date1989-03-01
P1433published inClinical RheumatologyQ15754927
P1476titleTheoretical mechanism for the gastrointestinal safety of etodolac: selective sparing of cytoprotective prostaglandins
P478volume8 Suppl 1

Reverse relations

cites work (P2860)
Q67898161Double-blind, parallel comparison of etodolac and indomethacin in patients with osteoarthritis of the knee
Q68441561Endoscopic evaluation of etodolac and naproxen, and their relative effects on gastric and duodenal prostaglandins
Q38254644Etodolac, a new nonsteroidal anti-inflammatory drug: gastrointestinal microbleeding and endoscopic studies
Q34591536Etodolac. A reappraisal of its pharmacology and therapeutic use in rheumatic diseases and pain states

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