O-GlcNAcylation and its role in the immune system

scientific article published on 29 April 2020

O-GlcNAcylation and its role in the immune system is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1186/S12929-020-00648-9
P932PMC publication ID7189445
P698PubMed publication ID32349769

P50authorKuo-I LinQ90673109
P2093author name stringChia-Lin Weng
Yi-Hsuan Chang
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Modification of RelA by O-linked N-acetylglucosamine links glucose metabolism to NF-κB acetylation and transcriptionQ30419967
Quantification of O-GlcNAc protein modification in neutrophils by flow cytometryQ30532863
A monoclonal antibody against a family of nuclear pore proteins (nucleoporins): O-linked N-acetylglucosamine is part of the immunodeterminantQ30734241
Alternative O-glycosylation/O-phosphorylation of serine-16 in murine estrogen receptor beta: post-translational regulation of turnover and transactivation activityQ31813156
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Dynamic interplay between O-linked N-acetylglucosaminylation and glycogen synthase kinase-3-dependent phosphorylationQ33284870
Cross-talk between GlcNAcylation and phosphorylation: site-specific phosphorylation dynamics in response to globally elevated O-GlcNAcQ36893523
Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancyQ36988176
Up-regulation of O-GlcNAc transferase with glucose deprivation in HepG2 cells is mediated by decreased hexosamine pathway flux.Q37081885
Loss of p53 enhances catalytic activity of IKKbeta through O-linked beta-N-acetyl glucosamine modificationQ37117710
Temporal regulation of Lsp1 O-GlcNAcylation and phosphorylation during apoptosis of activated B cellsQ37208251
Lymphocyte activation induces rapid changes in nuclear and cytoplasmic glycoproteinsQ37413972
Neutrophil function: from mechanisms to diseaseQ37973773
How RIG-I like receptors activate MAVS.Q38460076
Necroptosis and InflammationQ38729108
Changes in O-Linked N-Acetylglucosamine (O-GlcNAc) Homeostasis Activate the p53 Pathway in Ovarian Cancer Cells.Q38758695
Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells.Q38845236
The Biochemistry of O-GlcNAc Transferase: Which Functions Make It Essential in Mammalian Cells?Q38863245
O-GlcNAcylation in Cancer Biology: Linking Metabolism and SignalingQ38876699
O-GlcNAcylation and neurodegenerationQ38920683
O-GlcNAcylation and p50/p105 binding of c-Rel are dynamically regulated by LPS and glucosamine in BV2 microglia cellsQ39155899
Protein O-GlcNAcylation: emerging mechanisms and functionsQ39295247
Denitrosylation of S-nitrosylated OGT is triggered in LPS-stimulated innate immune responseQ39567711
Glucosamine exerts a neuroprotective effect via suppression of inflammation in rat brain ischemia/reperfusion injuryQ39663614
The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitinationQ39757179
Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation.Q40147884
Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolismQ40390896
β‐Amyloid precursor protein is modified with O‐linked N‐acetylglucosamineQ40468759
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O-GlcNAc modification is an endogenous inhibitor of the proteasomeQ40607491
Kinetic characterization of human glutamine-fructose-6-phosphate amidotransferase I: potent feedback inhibition by glucosamine 6-phosphateQ40751230
MicroRNA-15b Suppresses Th17 Differentiation and Is Associated with Pathogenesis of Multiple Sclerosis by Targeting O-GlcNAc Transferase.Q50878107
Insights into activity and inhibition from the crystal structure of human O-GlcNAcase.Q51084028
Macrophages and the Recovery from Acute and Chronic Inflammation.Q51270292
Glycosylation of chromosomal proteins: localization of O-linked N-acetylglucosamine in Drosophila chromatin.Q52452782
An Overview on the Clinical Development of Tau-Based Therapeutics.Q52594209
Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation.Q53434499
The subcellular distribution of terminal N-acetylglucosamine moieties. Localization of a novel protein-saccharide linkage, O-linked GlcNAc.Q54426511
The Nutrient-Sensing Hexosamine Biosynthetic Pathway as the Hub of Cancer Metabolic Rewiring.Q55497180
Deficient O-GlcNAc Glycosylation Impairs Regulatory T Cell Differentiation and Notch Signaling in Autoimmune HepatitisQ57816684
Natural Killer Cells: Development, Maturation, and Clinical UtilizationQ58785734
The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylationQ61124946
Nutrient regulation of signaling and transcriptionQ64251360
Glucosamine prevents polarization of cytotoxic granules in NK-92 cells by disturbing FOXO1/ERK/paxillin phosphorylation.Q64982206
An intrinsic membrane glycoprotein of the golgi apparatus with O-linked N-acetylglucosamine facing the cytosolQ67980880
Translocation of UDP-N-acetylglucosamine into vesicles derived from rat liver rough endoplasmic reticulum and Golgi apparatusQ70090012
O-linked N-acetylglucosamine is attached to proteins of the nuclear pore. Evidence for cytoplasmic and nucleoplasmic glycoproteinsQ70345116
Erythrocytes contain cytoplasmic glycoproteins. O-linked GlcNAc on Band 4.1.Q70363440
Topography and polypeptide distribution of terminal N-acetylglucosamine residues on the surfaces of intact lymphocytes. Evidence for O-linked GlcNAcQ70466786
T cell receptor beta chain gene rearrangement and selection during thymocyte development in adult miceQ71680581
Mitochondrial and nucleocytoplasmic targeting of O-linked GlcNAc transferaseQ78827061
Stat5 activation plays a critical role in Th2 differentiationQ79291245
The specific and essential role of MAVS in antiviral innate immune responsesQ83817506
Inhibition of Enhancer of zeste homolog 2 (EZH2) induces natural killer cell-mediated eradication of hepatocellular carcinoma cellsQ88181756
Metabolic Inhibitors of O-GlcNAc Transferase That Act In Vivo Implicate Decreased O-GlcNAc Levels in Leptin-Mediated Nutrient SensingQ88658178
Deficiency in intestinal epithelial O-GlcNAcylation predisposes to gut inflammationQ89240862
Elevated O-GlcNAcylation enhances pro-inflammatory Th17 function by altering the intracellular lipid microenvironmentQ90212429
O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate ImmunityQ90449901
Therapeutically exploiting STAT3 activity in cancer - using tissue repair as a road mapQ90712078
Genetic recoding to dissect the roles of site-specific protein O-GlcNAcylationQ91152191
Inflammation-induced glycolytic switch controls suppressivity of mesenchymal stem cells via STAT1 glycosylationQ91212037
Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancerQ91614492
O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3Q91631677
Metabolic Regulations in Hematopoietic Stem CellsQ92140577
Increased O-GlcNAcylation of c-Myc Promotes Pre-B Cell ProliferationQ92634106
MAVS O-GlcNAcylation Is Essential for Host Antiviral Immunity against Lethal RNA VirusesQ92957671
Blocked O-GlcNAc cycling disrupts mouse hematopoeitic stem cell maintenance and early T cell developmentQ92995104
Glucosamine improves survival in a mouse model of sepsis and attenuates sepsis-induced lung injury and inflammationQ93222337
Intrinsic membrane glycoproteins with cytosol-oriented sugars in the endoplasmic reticulumQ33552214
Cellular responses to FMLP challenging: a mini-reviewQ33721808
Activation of the transcriptional function of the NF-κB protein c-Rel by O-GlcNAc glycosylationQ33791683
The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector functionQ33838591
A Caenorhabditis elegans model of insulin resistance: altered macronutrient storage and dauer formation in an OGT-1 knockoutQ33913856
Glycosylation of nucleocytoplasmic proteins: signal transduction and O-GlcNAcQ33939701
T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cellsQ33952975
Requirement for transcription factor NFAT in interleukin-2 expressionQ33957551
Dynamic O-glycosylation of nuclear and cytosolic proteins: further characterization of the nucleocytoplasmic beta-N-acetylglucosaminidase, O-GlcNAcaseQ34109163
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activationQ34242691
Mapping of O-GlcNAc sites of 20 S proteasome subunits and Hsp90 by a novel biotin-cystamine tag.Q34255802
Purification and characterization of an O-GlcNAc selective N-acetyl-beta-D-glucosaminidase from rat spleen cytosol.Q34330440
Glycosylation of the c-Myc transactivation domainQ34331166
The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin alphaQ34347600
HLA-G remains a mysteryQ34382901
The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolismQ34411887
Transcription factor Foxo1 is a negative regulator of natural killer cell maturation and functionQ34467070
The thymus as an inductive site for T lymphopoiesisQ34628878
Chemotactic signaling pathways in neutrophils: from receptor to actin assemblyQ34713881
A lipid-droplet-targeted O-GlcNAcase isoform is a key regulator of the proteasomeQ35140884
Dynamic interplay between O-glycosylation and O-phosphorylation of nucleocytoplasmic proteins: a new paradigm for metabolic control of signal transduction and transcriptionQ35185681
Regulation of TCR alpha and beta gene allelic exclusion during T-cell developmentQ35232298
A little sugar goes a long way: the cell biology of O-GlcNAcQ35261648
The active site of O-GlcNAc transferase imposes constraints on substrate sequenceQ35735257
Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growthQ35849703
O-GlcNAcylation of kinasesQ36070732
Inhibition of in vitro nuclear transport by a lectin that binds to nuclear poresQ36215912
Nuclear pore complex glycoproteins contain cytoplasmically disposed O-linked N-acetylglucosamineQ36216148
The requirement for Notch signaling at the beta-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor.Q36227978
Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viabilityQ36233025
Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activityQ36435156
Overexpression of X-linked genes in T cells from women with lupusQ36755936
Regulation of the O-linked beta-N-acetylglucosamine transferase by insulin signaling.Q36798755
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue1
P921main subjectN-acetylglucosaminyltransferasesQ76877751
P304page(s)57
P577publication date2020-04-29
P1433published inJournal of Biomedical ScienceQ15759332
P1476titleO-GlcNAcylation and its role in the immune system
P478volume27

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