BTK Has Potential to Be a Prognostic Factor for Lung Adenocarcinoma and an Indicator for Tumor Microenvironment Remodeling: A Study Based on TCGA Data Mining

scientific article published on 15 April 2020

BTK Has Potential to Be a Prognostic Factor for Lung Adenocarcinoma and an Indicator for Tumor Microenvironment Remodeling: A Study Based on TCGA Data Mining is …
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scholarly articleQ13442814

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P356DOI10.3389/FONC.2020.00424
P932PMC publication ID7175916
P698PubMed publication ID32351880

P2093author name stringBo Li
Xiao-Xue Qin
Ke-Wei Bi
Xu-Ge Wei
P2860cites workBruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domainQ24321955
Tumor-associated stromal cells as key contributors to the tumor microenvironmentQ26741825
Innate and adaptive immune cells in the tumor microenvironmentQ27008342
Microenvironmental regulation of tumor progression and metastasisQ29615504
Selective antitumor activity of ibrutinib in EGFR-mutant non-small cell lung cancer cellsQ34354339
Lung cancer: Biology and treatment optionsQ36328370
The role of the tumor-microenvironment in lung cancer-metastasis and its relationship to potential therapeutic targetsQ38157427
Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trialQ38364028
Bruton's tyrosine kinase (BTK) as a promising target in solid tumorsQ38713716
Immunotherapy Comes of Age in Lung CancerQ38837496
Lung cancer: current therapies and new targeted treatmentsQ38940816
First-Line Nivolumab in Stage IV or Recurrent Non-Small-Cell Lung Cancer.Q39388286
BTK Modulates p53 Activity to Enhance Apoptotic and Senescent Responses.Q40581051
CD8+CD103+ tumor-infiltrating lymphocytes are tumor-specific tissue-resident memory T cells and a prognostic factor for survival in lung cancer patientsQ42158777
BTK blocks the inhibitory effects of MDM2 on p53 activityQ47164914
Prognostic value of tumor-infiltrating lymphocytes differs depending on histological type and smoking habit in completely resected non-small-cell lung cancerQ51584147
The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune MicroenvironmentQ57457564
BTK: a two-faced effector in cancer and tumour suppressionQ58594085
The Ibr-7 derivative of ibrutinib exhibits enhanced cytotoxicity against non-small cell lung cancer cells via targeting of mTORC1/S6 signalingQ64113606
Beyond PD-L1 Markers for Lung Cancer ImmunotherapyQ64252367
B Cell-Based Cancer Immunotherapy.Q64913188
Intratumoral immunoglobulin isotypes predict survival in lung adenocarcinoma subtypesQ91005217
Development of BTK inhibitors for the treatment of B-cell malignanciesQ91299841
Targeting BTK in CLL: Beyond IbrutinibQ91560342
Metabolic rewiring beyond Warburg in chronic lymphocytic leukemia: How much do we actually know?Q91645074
The impact of systemic precision medicine and immunotherapy treatments on brain metastasesQ91709281
Identification of prognostic gene signature associated with microenvironment of lung adenocarcinomaQ91710727
The immunotherapeutic landscape in non-small cell lung cancer and its surgical horizonsQ91968926
A Phase II Study of Ibrutinib in Advanced Neuroendocrine NeoplasmsQ92255495
p65BTK is a novel potential actionable target in KRAS-mutated/EGFR-wild type lung adenocarcinomaQ92757551
A Phase 1b/2 Study of the Bruton Tyrosine Kinase Inhibitor Ibrutinib and the PD-L1 Inhibitor Durvalumab in Patients with Pretreated Solid TumorsQ92962904
Immune evasion before tumour invasion in early lung squamous carcinogenesisQ93053561
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesCytoscapeQ3699942
ggplot2Q326489
limmaQ112236343
P921main subjectdata miningQ172491
P304page(s)424
P577publication date2020-04-15
P1433published inFrontiers in OncologyQ26839986
P1476titleBTK Has Potential to Be a Prognostic Factor for Lung Adenocarcinoma and an Indicator for Tumor Microenvironment Remodeling: A Study Based on TCGA Data Mining
P478volume10

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