Tanshinone IIA inhibits oral squamous cell carcinoma via reducing Akt-c-Myc signaling-mediated aerobic glycolysis

scientific article published on 18 May 2020

Tanshinone IIA inhibits oral squamous cell carcinoma via reducing Akt-c-Myc signaling-mediated aerobic glycolysis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/S41419-020-2579-9
P932PMC publication ID7235009
P698PubMed publication ID32424132

P2093author name stringMing Li
Wei Li
Feng Gao
Qing Zhao
Wenbin Liu
Huilan Zuo
P2860cites workRepression of Hexokinases II-Mediated Glycolysis Contributes to Piperlongumine-Induced Tumor Suppression in Non-Small Cell Lung Cancer CellsQ64078679
Effect of glycolysis inhibition by miR-448 on glioma radiosensitivityQ90018202
Tumor depth of invasion and prognosis of early-stage oral squamous cell carcinoma: A meta-analysisQ90104329
Long non‑coding RNA urothelial cancer associated 1 regulates radioresistance via the hexokinase 2/glycolytic pathway in cervical cancerQ90278225
Deguelin attenuates non-small cell lung cancer cell metastasis through inhibiting the CtsZ/FAK signaling pathwayQ90291830
Tobacco and oral squamous cell carcinoma: A review of carcinogenic pathwaysQ90468932
Xanthohumol inhibits colorectal cancer cells via downregulation of Hexokinases II-mediated glycolysisQ90599381
Cancer statistics, 2019Q90941571
The immunoregulatory protein B7-H3 promotes aerobic glycolysis in oral squamous carcinoma via PI3K/Akt/mTOR pathwayQ91317461
Association between immunohistochemical expression of matrix metalloproteinases and metastasis in oral squamous cell carcinoma: Systematic review and meta-analysisQ91370866
Oral Cancer: Genetics and the Role of Precision MedicineQ91401539
Lymph node ratio as prognostic variable in oral squamous cell carcinomas: Systematic review and meta-analysisQ91407541
Cdh1-mediated Skp2 degradation by dioscin reprogrammes aerobic glycolysis and inhibits colorectal cancer cells growthQ91733324
Tanshinone IIA Reverses Gefitinib-Resistance In Human Non-Small-Cell Lung Cancer Via Regulation Of VEGFR/Akt PathwayQ91737684
Opposite Effects of Garcinol on Tumor Energy Metabolism in Oral Squamous Cell Carcinoma CellsQ91912939
Tanshinone IIA enhances the inhibitory effect of imatinib on proliferation and motility of acute leukemia cell line TIB‑152 in vivo and in vitro by inhibiting the PI3K/AKT/mTOR signaling pathwayQ92366908
The Influence of Met Receptor Level on HGF-Induced Glycolytic Reprogramming in Head and Neck Squamous Cell CarcinomaQ92661565
Hexokinase 2 dimerization and interaction with voltage-dependent anion channel promoted resistance to cell apoptosis induced by gemcitabine in pancreatic cancerQ92700885
Skp2-mediated ubiquitination and mitochondrial localization of Akt drive tumor growth and chemoresistance to cisplatinQ92757921
Effects and Mechanism of Tanshinone II A in Proliferation, Apoptosis, and Migration of Human Colon Cancer CellsQ93098059
Tanshinone IIA inhibits glucose metabolism leading to apoptosis in cervical cancerQ93111153
Hallmarks of Cancer: The Next GenerationQ22252312
Warburg effect, hexokinase-II, and radioresistance of laryngeal carcinomaQ28072714
Aerobic glycolysis: meeting the metabolic requirements of cell proliferationQ29615178
Poor prognosis of hexokinase 2 overexpression in solid tumors of digestive system: a meta-analysisQ30234765
Deguelin inhibits non-small cell lung cancer via down-regulating Hexokinases II-mediated glycolysisQ33779169
Targeting MCL-1 sensitizes human esophageal squamous cell carcinoma cells to cisplatin-induced apoptosisQ33851111
Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic functionQ33966115
Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt.Q34554825
Histological and molecular aspects of oral squamous cell carcinoma (Review)Q34662689
Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagyQ34924245
Overexpression of pyruvate kinase M2 associates with aggressive clinicopathological features and unfavorable prognosis in oral squamous cell carcinomaQ36213166
Betel nut chewing, oral premalignant lesions, and the oral microbiomeQ36287412
Tanshinones: sources, pharmacokinetics and anti-cancer activitiesQ36396623
MYC-induced cancer cell energy metabolism and therapeutic opportunitiesQ37438881
EZH2-mediated Puma gene repression regulates non-small cell lung cancer cell proliferation and cisplatin-induced apoptosisQ37636628
EGF induces epithelial-mesenchymal transition and cancer stem-like cell properties in human oral cancer cells via promoting Warburg effectQ37706017
Hexokinase 2 enhances the metastatic potential of tongue squamous cell carcinoma via the SOD2-H2O2 pathwayQ37709470
Resveratrol inhibits Hexokinases II mediated glycolysis in non-small cell lung cancer via targeting Akt signaling pathwayQ38732069
MicroRNA-340 Mediates Metabolic Shift in Oral Squamous Cell Carcinoma by Targeting Glucose Transporter-1.Q38821783
Phosphorylation by Glycogen Synthase Kinase-3 Controls c-Myc Proteolysis and Subnuclear LocalizationQ40625392
High-throughput cell-based compound screen identifies pinosylvin methyl ether and tanshinone IIA as inhibitors of castration-resistant prostate cancerQ42098076
Deguelin, an Aurora B Kinase Inhibitor, Exhibits Potent Anti-Tumor Effect in Human Esophageal Squamous Cell CarcinomaQ45874344
Hexokinase 2 (HK2), the tumor promoter in glioma, is downregulated by miR-218/Bmi1 pathwayQ47151726
Overexpression of hypoxia-inducible factor and metabolic pathways: possible targets of cancerQ47153258
Hexokinase 2 confers resistance to cisplatin in ovarian cancer cells by enhancing cisplatin-induced autophagyQ47298651
Partial Substitution of Glucose with Xylitol Suppressed the Glycolysis and Selectively Inhibited the Proliferation of Oral Cancer Cells.Q48057543
Large Intergenic Non-coding RNA-RoR Inhibits Aerobic Glycolysis of Glioblastoma Cells via Akt Pathway.Q52340921
Knockdown of LncRNA-UCA1 suppresses chemoresistance of pediatric AML by inhibiting glycolysis through the microRNA-125a/hexokinase 2 pathway.Q52583847
Synergistic antitumor effects of tanshinone IIA and sorafenib or its derivative SC-1 in hepatocellular carcinoma cells.Q52720194
Salvanic acid B inhibits glycolysis in oral squamous cell carcinoma via targeting PI3K/AKT/HIF-1α signaling pathway.Q54978483
VDAC1 as Pharmacological Target in Cancer and Neurodegeneration: Focus on Its Role in Apoptosis.Q55129102
The anticancer mechanism investigation of Tanshinone II by pharmacological clustering in protein networkQ58101390
Hallmarks of Cancer-Related Newly Prognostic Factors of Oral Squamous Cell CarcinomaQ58772889
B7-H3 promotes aerobic glycolysis and chemoresistance in colorectal cancer cells by regulating HK2Q64070924
P433issue5
P921main subjectoral squamous cell carcinomaQ18553522
P304page(s)381
P577publication date2020-05-18
P1433published inCell Death and DiseaseQ2197222
P1476titleTanshinone IIA inhibits oral squamous cell carcinoma via reducing Akt-c-Myc signaling-mediated aerobic glycolysis
P478volume11

Search more.