Does the noncompetitive NMDA receptor antagonist dizocilpine (MK801) really block behavioural sensitization associated with repeated drug administration?

scientific article published in November 1998

Does the noncompetitive NMDA receptor antagonist dizocilpine (MK801) really block behavioural sensitization associated with repeated drug administration? is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S0165-6147(98)01255-3
P698PubMed publication ID9850608

P2093author name stringT M Tzschentke
W J Schmidt
P2860cites workCompetitive and non-competitive N-methyl-D-aspartate antagonists fail to prevent the induction of methamphetamine-induced sensitizationQ28318966
Anticataleptic effects of the N-methyl-D-aspartate antagonist MK-801 in ratsQ28342678
Interactions of MK-801 and GYKI 52466 with morphine and amphetamine in place preference conditioning and behavioural sensitizationQ34420110
The NMDA receptor competitive antagonist CPP modulates benzodiazepine tolerance and discontinuationQ34449371
The behavioral pharmacology of NMDA receptor antagonistsQ37863320
Excitatory amino acid receptors and synaptic plasticityQ37889910
The contribution of Pavlovian conditioning to drug tolerance and dependenceQ39767699
Excitatory amino acids and drugs of abuse: a role for N-methyl-d-aspartate receptors in drug tolerance, sensitization and physical dependenceQ40480630
Interactions between dopamine and excitatory amino acids in behavioral sensitization to psychostimulantsQ40530386
The role of excitatory amino acids in behavioral sensitization to psychomotor stimulantsQ41749963
Amphetamine behavioral sensitization and the excitatory amino acidsQ44745120
Locomotor-activating effects of the D2 agonist bromocriptine show environment-specific sensitization following repeated injectionsQ44882687
Does dizocilpine (MK-801) selectively block the enhanced responsiveness to repeated amphetamine administration?Q46204457
Excitatory amino acid antagonists (kynurenic acid and MK-801) attenuate the development of morphine tolerance in the ratQ46904809
The NMDA antagonist MK-801 can impair attention to exteroceptive stimuliQ48103292
MK-801 prevents alterations in the mesoaccumbens dopamine system associated with behavioral sensitization to amphetamine.Q48163465
Morphine-induced potentiation of brain stimulation reward is enhanced by MK-801.Q48230956
Coadministration of MK-801 with amphetamine, cocaine or morphine prevents rather than transiently masks the development of behavioral sensitizationQ48267682
Dopamine-glutamate interactions in the basal gangliaQ48318964
The NMDA antagonist, dizocilpine, enhances cocaine reinforcement without influencing mesoaccumbens dopamine transmissionQ48612417
Repeated administration of MK-801 produces sensitization to its own locomotor stimulant effects but blocks sensitization to amphetamineQ48638665
Dizocilpine prevents the development of tolerance to the sedative effects of diazepam in ratsQ48641419
Synergistic effects of cocaine and dizocilpine (MK-801) on brain stimulation rewardQ48682122
Progressive augmentation of striatal and accumbal preprotachykinin mRNA levels by chronic treatment with methamphetamine and effect of concurrent administration of the N-methyl-D-aspartate receptor antagonist MK-801.Q48771524
Systemic pretreatment with MK-801 (dizocilpine) increases breaking points for self-administration of cocaine on a progressive-ratio schedule in rats.Q51558396
Inhibition by MK-801 of cocaine-induced sensitization, conditioned place preference, and dopamine-receptor supersensitivity in mice.Q51582999
Inhibition of cocaine sensitization by MK-801, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist: evaluation by ambulatory activity in mice.Q51592919
The NMDA receptor and cocaine: Evidence that MK-801 can induce behavioral sensitization effectsQ51597277
Antagonist of N-methyl-D-aspartate receptors partially prevent the development of cocaine sensitization.Q51616968
Cocaine behavioral sensitization and the excitatory amino acids.Q51631322
Blockade of "reverse tolerance" to cocaine and amphetamine by MK-801.Q51759796
Inhibition of Morphine Tolerance and Dependence by the NMDA Receptor Antagonist MK-801Q52052445
NMDA antagonists make learning and recall state-dependent.Q52072564
MK-801 inhibits methamphetamine-induced conditioned place preference and behavioral sensitization to apomorphine in mice.Q52197218
MK-801 (dizocilpine): synergist and conditioned stimulus in bromocriptine-induced psychomotor sensitization.Q52202092
N-methyl-D-aspartic acid-receptor antagonists block morphine-induced conditioned place preference in rats.Q52207692
The development of behavioral sensitization to apomorphine is blocked by MK-801.Q52222338
Development of both conditioning and sensitization of the behavioral activating effects of amphetamine is blocked by the non-competitive NMDA receptor antagonist, MK-801.Q52228738
State dependent learning and morphine tolerance.Q52252117
The NMDA antagonist dizocilpine (M K801) attenuates tolerance to nicotine in rats.Q52300234
Effects of repeated MK-801 on ambulation in mice and in sensitization following methamphetamineQ68042255
Evidence for dissociable mechanisms of amphetamine- and stress-induced behavioral sensitization: effects of MK-801 and haloperidol pretreatmentQ71696058
Sensitization to apomorphine-induced rotational behavior in 6-OHDA-lesioned rats: effects of NMDA antagonists on drug responseQ71725984
MK-801 disrupts the expression but not the development of bromocriptine sensitization: a state-dependency interpretationQ71930932
NMDA antagonist effects on the development of L-dopa behavioral sensitization in ratsQ72201037
The role of corticosteroids in the acquisition of sensitization to locomotor stimulant effects of MK-801Q72406897
MK-801 prevents the development of behavioral sensitization during repeated morphine administrationQ72482348
MK-801-induced symptoms of sensitization. The lack of correlation with the extracellular concentration of dopamine in the rat prefrontal cortexQ72691779
Competitive and noncompetitive NMDA antagonists block sensitization to methamphetamineQ72747585
A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulantsQ73950418
Does dizocilpine (MK-801) inhibit the development of morphine-induced behavioural sensitization in rats?Q73994266
Dizocilpine (MK801): use or abuse?Q74537557
P433issue11
P304page(s)447-451
P577publication date1998-11-01
P1433published inTrends in Pharmacological SciencesQ2451474
P1476titleDoes the noncompetitive NMDA receptor antagonist dizocilpine (MK801) really block behavioural sensitization associated with repeated drug administration?
P478volume19

Reverse relations

cites work (P2860)
Q77343245An integrated view of pathophysiological models of schizophrenia
Q73598954Differential effects of quinolinic acid lesions of the medial prefrontal cortex on the expression of morphine- and dizocilpine- induced behavioural plasticity in the rat
Q34372253Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897-NR1.
Q34970664Experimental genetic approaches to addiction.
Q46815350Genetic NMDA receptor deficiency disrupts acute and chronic effects of cocaine but not amphetamine
Q52022912Memory of an operant response and of depressed mood retained in activation states of 5-HT(1A) receptors: evidence from rodent models.
Q46906799NMDA receptor antagonists inhibit opiate antinociceptive tolerance and locomotor sensitization in rats
Q52176677NMDA receptors and behavioural sensitization: beyond dizocilpine.
Q42689768Naltrexone potentiates both amnestic and anxiolytic effects of chlordiazepoxide in mice
Q43875632Persistent behavioral sensitization to chronic L-DOPA requires A2A adenosine receptors.
Q44540861The 5-HT2A receptor antagonist M100,907 attenuates motor and 'impulsive-type' behaviours produced by NMDA receptor antagonism
Q51396429The dopamine antagonist sch 23390 reverses dizocilpine-induced blockade of cocaine sensitization.
Q95301997Tzschentke and schmidt reply
Q43662467Uncompetitive NMDA receptor antagonists potentiate morphine antinociception recorded from the tail but not from the hind paw in rats

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