Structural basis for RNA replication by the SARS-CoV-2 polymerase

scientific article published on 22 May 2020

Structural basis for RNA replication by the SARS-CoV-2 polymerase is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CELL.2020.05.034
P932PMC publication ID7242921
P698PubMed publication ID32526208
P8299Semantic Scholar corpus ID218764530

P50authorRao ZiheQ9030008
P2093author name stringYan Zhu
Yan Gao
Zhijie Liu
Wenqing Xu
Xiang Fang
Luke W Guddat
Liming Yan
Zhiyong Lou
Haitao Yang
Peng Gong
Quan Wang
Chen Zhu
Biao Jiang
Hailong Gao
Qianqian Sun
Xiaobao Yang
Xiuna Yang
Qiaojie Liu
Fengjiang Liu
Haofeng Wang
Ji Ge
Yucen Huang
Wenxin Ji
Jiqin Wu
An Mu
P2860cites workPyMOLQ1373457
NIH Image to ImageJ: 25 years of image analysisQ23319322
A second, non-canonical RNA-dependent RNA polymerase in SARS CoronavirusQ27477549
Structural basis for active site closure by the poliovirus RNA-dependent RNA polymeraseQ27666339
Nonstructural Proteins 7 and 8 of Feline Coronavirus Form a 2:1 Heterotrimer That Exhibits Primer-Independent RNA Polymerase ActivityQ27677154
Distinct Conformations of a Putative Translocation Element in Poliovirus PolymeraseQ27681334
UCSF Chimera--a visualization system for exploratory research and analysisQ27860666
Towards automated crystallographic structure refinement with phenix.refineQ27860678
Features and development of CootQ27861079
A decade after SARS: strategies for controlling emerging coronavirusesQ28817689
Structural basis of viral RNA-dependent RNA polymerase catalysis and translocationQ28829956
Optimal determination of particle orientation, absolute hand, and contrast loss in single-particle electron cryomicroscopyQ29547579
Automated electron microscope tomography using robust prediction of specimen movementsQ29616585
SARS and MERS: recent insights into emerging coronavirusesQ30249325
cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determinationQ30398255
One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activitiesQ34218422
Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeysQ34516555
Improved native affinity purification of RNA.Q35902036
COVID-19, SARS and MERS: are they closely related?Q90799557
Structure of the RNA-dependent RNA polymerase from COVID-19 virusQ91816382
Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potencyQ91872888
Structural snapshots of actively transcribing influenza polymeraseQ92503263
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivirQ94482766
Structure of replicating SARS-CoV-2 polymeraseQ95301171
Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structuresQ95831544
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, ChinaQ83767469
Identification and Characterization of a Human Coronavirus 229E Nonstructural Protein 8-Associated RNA 3'-Terminal Adenylyltransferase ActivityQ84315404
Small-Molecule Antiviral β-d--Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to ResistanceQ84315917
A Novel Coronavirus from Patients with Pneumonia in China, 2019Q86729469
New nsp8 isoform suggests mechanism for tuning viral RNA synthesisQ36922655
Insights into SARS-CoV transcription and replication from the structure of the nsp7-nsp8 hexadecamerQ38319878
The future of antivirals: broad-spectrum inhibitorsQ38622424
UCSF ChimeraX: Meeting Modern Challenges in Visualization and Analysis.Q38677893
Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging VirusesQ38719353
The SARS-coronavirus nsp7+nsp8 complex is a unique multimeric RNA polymerase capable of both de novo initiation and primer extensionQ41578444
MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopyQ41598828
Quantifying the local resolution of cryo-EM density mapsQ41609859
High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopyQ42103385
Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase.Q50099241
Hosts and Sources of Endemic Human Coronaviruses.Q51146867
Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease.Q53704198
New tools for automated high-resolution cryo-EM structure determination in RELION-3Q58563641
Drug Repurposing for Viral Infectious Diseases: How Far Are We?Q59360930
Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by RemdesivirQ64359892
P4510describes a project that usesImageJQ1659584
P921main subjectstructural biologyQ908902
RNA-directed RNA polymerase [SARS-CoV-2]Q90042395
SARS-CoV-2Q82069695
P577publication date2020-05-22
P1433published inCellQ655814
P1476titleStructural basis for RNA replication by the SARS-CoV-2 polymerase

Reverse relations

cites work (P2860)
Q104469729A dynamic regulatory interface on SARS-CoV-2 RNA polymerase
Q97426484A pH-dependent switch mediates conformational masking of SARS-CoV-2 spike
Q110176615A structural view of the SARS-CoV-2 virus and its assembly
Q107981453Allosteric Activation of SARS-CoV-2 RNA-Dependent RNA Polymerase by Remdesivir Triphosphate and Other Phosphorylated Nucleotides
Q100960135An Overview of the Crystallized Structures of the SARS-CoV-2
Q111442216An all-out assault on SARS-CoV-2 replication
Q102152136Architecture of a SARS-CoV-2 mini replication and transcription complex
Q99401090COVID-19 and its Therapeutics: Special Emphasis on Mesenchymal Stem Cells Based Therapy
Q110453915Cholesterol-Rich Lipid Rafts as Platforms for SARS-CoV-2 Entry
Q107675583Compartmentalization-aided interaction screening reveals extensive high-order complexes within the SARS-CoV-2 proteome
Q106626789Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM
Q104073053Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM
Q98775561Coronavirus RNA Proofreading: Molecular Basis and Therapeutic Targeting
Q101051357Coronavirus biology and replication: implications for SARS-CoV-2
Q107343665Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading
Q98390836Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
Q102374059Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis
Q107033036Drug repurposing screens reveal FDA approved drugs active against SARS-Cov-2
Q107143917Dysregulation of Cell Signaling by SARS-CoV-2
Q107404629Energetic and structural features of SARS-CoV-2 N-protein co-assemblies with nucleic acids
Q106460575Energetic and structural features of SARS-CoV-2 N-protein co-assemblies with nucleic acids
Q106452837Extensive High-Order Complexes within SARS-CoV-2 Proteome Revealed by Compartmentalization-Aided Interaction Screening
Q107349299Fluorescent Glycan Fingerprinting of SARS2 Spike Proteins
Q107980425Identification of guanylyltransferase activity in the SARS-CoV-2 RNA polymerase
Q100737230Immunity, endothelial injury and complement-induced coagulopathy in COVID-19
Q107334999Mass spectrometric based detection of protein nucleotidylation in the RNA polymerase of SARS-CoV-2
Q104527452Mass spectrometric based detection of protein nucleotidylation in the RNA polymerase of SARS-CoV-2
Q107202926Mechanism of Inhibition of the Reproduction of SARS-CoV-2 and Ebola Viruses by Remdesivir
Q108084260Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis
Q115250684Molecular Insights into the Flavivirus Replication Complex
Q104527170Molecular architecture of the SARS-CoV-2 virus
Q107138033Mutations in SARS-CoV-2 nsp7 and nsp8 proteins and their predicted impact on replication/transcription complex structure
Q106873607No evidence for basigin/CD147 as a direct SARS-CoV-2 spike binding receptor
Q99552324Real-time conformational dynamics of SARS-CoV-2 spikes on virus particles
Q107343704Reconstitution and functional characterization of SARS-CoV-2 proofreading complex
Q107713714Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication
Q101235458Replication of the SARS-CoV-2 genome
Q101210520Replication transcription complex binds SARS-CoV-2 genomic RNA
Q107273150Revealing the Structural Plasticity of SARS-CoV-2 nsp7 and nsp8 Using Structural Proteomics
Q101565552SARS-CoV-2 Assembly and Egress Pathway Revealed by Correlative Multi-modal Multi-scale Cryo-imaging
Q101235523SARS-CoV-2 Genome Replication and Transcription
Q106452685SARS-CoV-2 Nsp8 N-terminal domain dimerizes and harbors autonomously folded elements
Q104502003SARS-CoV-2 Nucleocapsid protein attenuates stress granule formation and alters gene expression via direct interaction with host mRNAs
Q98665489SARS-CoV-2 ORF9c Is a Membrane-Associated Protein that Suppresses Antiviral Responses in Cells
Q106452777SARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocation
Q106460589SARS-CoV-2, the pandemic coronavirus: Molecular and structural insights
Q110566440SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/late endosome entry
Q99731147Signal hotspot mutations in SARS-CoV-2 genomes evolve as the virus spreads and actively replicates in different parts of the world
Q107073747Snake venom phospholipases A2 possess a strong virucidal activity against SARS-CoV-2 in vitro and block the cell fusion mediated by spike glycoprotein interaction with the ACE2 receptor
Q98388186Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex
Q107203059Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir
Q104468473Structural Characterization of SARS-CoV-2: Where We Are, and Where We Need to Be
Q107343676Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex
Q97531111Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex
Q104468598Structural basis for the inhibition of the papain-like protease of SARS-CoV-2 by small molecules
Q107981452Structure and function of SARS-CoV-2 polymerase
Q104451357Structures, conformations and distributions of SARS-CoV-2 spike protein trimers on intact virions
Q102056152Targeting SARS-CoV-2 Proteases and Polymerase for COVID-19 Treatment: State of the Art and Future Opportunities
Q106626821The SARS-CoV-2 Spike protein has a broad tropism for mammalian ACE2 proteins
Q110185116The atomic portrait of SARS‐CoV‐2 as captured by cryo‐electron microscopy
Q110644262The intrinsically disordered SARS-CoV-2 nucleoprotein in dynamic complex with its viral partner nsp3a
Q107981572The nucleotide addition cycle of the SARS-CoV-2 polymerase
Q110477732The nucleotide addition cycle of the SARS-CoV-2 polymerase
Q101235488Transcription of SARS-CoV-2 sgRNAs
Q107137976Two conserved oligomer interfaces of NSP7 and NSP8 underpin the dynamic assembly of SARS-CoV-2 RdRP
Q97940518Virus-host interactome and proteomic survey of PBMCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis