Signal Peptide Peptidase-Like 2c (SPPL2c) impairs vesicular transport and cleavage of SNARE proteins

scientific article published on 7 February 2019

Signal Peptide Peptidase-Like 2c (SPPL2c) impairs vesicular transport and cleavage of SNARE proteins is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.15252/EMBR.201846451
P932PMC publication ID6399617
P698PubMed publication ID30733281

P50authorRegina FluhrerQ63092251
Stefan F LichtenthalerQ73197474
Regina FeederleQ87822177
Artur MayerhoferQ88992184
Bernd SchröderQ89671442
P2093author name stringJulia von Blume
Martina Haug-Kröper
Merav D Shmueli
Torben Mentrup
Stephan A Müller
Alkmini A Papadopoulou
Johannes Niemeyer
P2860cites workThe α-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b)Q24300479
Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilinsQ24305015
Molecular characterisation of 'transmembrane protein 192' (TMEM192), a novel protein of the lysosomal membraneQ24305928
Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysisQ24311748
Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tailQ24337321
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Maintenance of Golgi structure and function depends on the integrity of ER exportQ24653507
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Sugar-coated sperm: Unraveling the functions of the mammalian sperm glycocalyxQ27001029
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Cell-surface expression of a new splice variant of the mouse signal peptide peptidaseQ28242598
Human sperm binding is mediated by the sialyl-Lewis(x) oligosaccharide on the zona pellucidaQ28245912
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The Genotype-Tissue Expression (GTEx) projectQ28657968
SNAREs--engines for membrane fusionQ29547230
Bi-directional protein transport between the ER and GolgiQ29615233
The mechanisms of vesicle budding and fusionQ29615234
Universal sample preparation method for proteome analysisQ29615662
Stop and go extraction tips for matrix-assisted laser desorption/ionization, nanoelectrospray, and LC/MS sample pretreatment in proteomicsQ29615818
Carbohydrates and fertilization: an overviewQ30428190
Secretory cargo sorting by Ca2+-dependent Cab45 oligomerization at the trans-Golgi networkQ30755585
Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitorQ31420350
VAMP-1: a synaptic vesicle-associated integral membrane proteinQ33583102
Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteinsQ33797023
Mammalian sperm acrosome: formation, contents, and functionQ33970886
Accurate proteome-wide label-free quantification by delayed normalization and maximal peptide ratio extraction, termed MaxLFQ.Q34157715
Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3).Q34310343
Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathwaysQ34469573
Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylationQ34807554
Sterile inflammation as a factor in human male infertility: Involvement of Toll like receptor 2, biglycan and peritubular cellsQ36193766
Latest emerging functions of SPP/SPPL intramembrane proteasesQ36331190
Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving ProteasesQ36419261
Lectin binding of human sperm associates with DEFB126 mutation and serves as a potential biomarker for subfertilityQ36527122
Signal peptide peptidases: a family of intramembrane-cleaving proteases that cleave type 2 transmembrane proteins.Q37476307
Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteasesQ38149887
FANTOM5 CAGE profiles of human and mouse samplesQ38604042
Signal peptide peptidase-mediated nuclear localization of heme oxygenase-1 promotes cancer cell proliferation and invasion independent of its enzymatic activityQ38984568
Protein sorting at the ER-Golgi interfaceQ39024908
Signal peptide peptidase and SPP-like proteases - Possible therapeutic targets?Q39380083
Acrosome biogenesis: Revisiting old questions to yield new insightsQ40830245
Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteasesQ40845419
Role of vesicle-associated syntaxin 5 in the assembly of pre-Golgi intermediatesQ41064399
The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chainQ41881169
Assessment of spermatogenesis through staging of seminiferous tubules.Q43437784
Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitorsQ44350630
SNARE proteins in membrane traffickingQ47878377
Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.Q52583319
The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholambanQ91409250
P4510describes a project that usesImageQuantQ112270642
P433issue3
P577publication date2019-02-07
P1433published inEMBO ReportsQ5323356
P1476titleSignal Peptide Peptidase-Like 2c (SPPL2c) impairs vesicular transport and cleavage of SNARE proteins
P478volume20

Reverse relations

Q91903241Regulating the regulator: intramembrane proteolysis of vesicular trafficking proteins and the SERCA regulator phospholambancites workP2860

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