Porcine epidemic diarrhea virus (PEDV): An update on etiology, transmission, pathogenesis, and prevention and control

scientific article published on 02 June 2020

Porcine epidemic diarrhea virus (PEDV): An update on etiology, transmission, pathogenesis, and prevention and control is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.VIRUSRES.2020.198045
P932PMC publication ID7266596
P698PubMed publication ID32502552

P2093author name stringLinda J Saif
Qiuhong Wang
Kwonil Jung
P2860cites workPorcine epidemic diarrhea virus variants with high pathogenicity, ChinaQ42867859
Characterizing the rapid spread of porcine epidemic diarrhea virus (PEDV) through an animal food manufacturing facility.Q44870172
Isotype-specific antibody-secreting cells in systemic and mucosal associated lymphoid tissues and antibody responses in serum of conventional pigs inoculated with PEDV.Q44933852
Evaluation of an accelerated hydrogen peroxide disinfectant to inactivate porcine epidemic diarrhea virus in swine feces on aluminum surfaces under freezing conditionsQ45323999
Trypsin-independent porcine epidemic diarrhea virus US strain with altered virus entry mechanism.Q45324199
Effects of porcine epidemic diarrhea virus infection on nursery pig intestinal function and barrier integrity.Q45325304
Mutations in the spike gene of porcine epidemic diarrhea virus associated with growth adaptation in vitro and attenuation of virulence in vivoQ45366670
Decreased activity of brush border membrane-bound digestive enzymes in small intestines from pigs experimentally infected with porcine epidemic diarrhea virusQ45415887
Differentiation of a Vero cell adapted porcine epidemic diarrhea virus from Korean field strains by restriction fragment length polymorphism analysis of ORF 3Q45723917
Lymphoproliferative responses and protection in conventional piglets inoculated orally with virulent or attenuated porcine epidemic diarrhoea virusQ45731362
Mucosal and systemic isotype-specific antibody responses and protection in conventional pigs exposed to virulent or attenuated porcine epidemic diarrhoea virus.Q45733575
Derivation of attenuated porcine epidemic diarrhea virus (PEDV) as vaccine candidateQ45748221
New insights into the dual recruitment of IgA+ B cells in the developing mammary gland.Q45927257
Altered Gut Microbiota Profiles in Sows and Neonatal Piglets Associated with Porcine Epidemic Diarrhea Virus InfectionQ46242598
Discovery of a novel swine enteric alphacoronavirus (SeACoV) in southern ChinaQ46268970
Swine enteric coronavirus disease: A review of 4 years with porcine epidemic diarrhoea virus and porcine deltacoronavirus in the United States and Canada.Q47546155
Evidence of porcine epidemic diarrhea virus (PEDV) shedding in semen from infected specific pathogen-free boarsQ47549024
Efficacy of genogroup 1 based porcine epidemic diarrhea live vaccine against genogroup 2 field strain in JapanQ49165254
Differences in the intestinal microbiota between uninfected piglets and piglets infected with porcine epidemic diarrhea virus.Q49979691
Evaluation of a peroxygen-based disinfectant for inactivation of porcine epidemic diarrhea virus at low temperatures on metal surfacesQ50058777
An epidemiological investigation of the early phase of the porcine epidemic diarrhea (PED) outbreak in Canadian swine herds in 2014: A case-control studyQ50185694
Discovery of seven novel Mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronavirusesQ24617467
Cellular entry of the porcine epidemic diarrhea virusQ26744418
Immunoglobulin Transporting Receptors Are Potential Targets for the Immunity Enhancement and Generation of Mammary Gland BioreactorQ26745000
Status of vaccines for porcine epidemic diarrhea virus in the United States and CanadaQ30248369
Porcine epidemic diarrhea: A retrospect from Europe and matters of debateQ30249539
Evolution, antigenicity and pathogenicity of global porcine epidemic diarrhea virus strainsQ30249672
Lactogenic immunity and vaccines for porcine epidemic diarrhea virus (PEDV): Historical and current conceptsQ30250229
Deciphering the biology of porcine epidemic diarrhea virus in the era of reverse genetics.Q30250231
Immune evasion of porcine enteric coronaviruses and viral modulation of antiviral innate signalingQ30250232
Differential Protein Analysis of IPEC-J2 Cells Infected with Porcine Epidemic Diarrhea Virus Pandemic and Classical Strains Elucidates the Pathogenesis of Infection.Q30401970
Role of transportation in spread of porcine epidemic diarrhea virus infection, United StatesQ33577229
Anorexia of infection: current prospectsQ33923398
Mammary gland immunology and neonate protection in pigs. Homing of lymphocytes into the MG.Q34014116
Porcine epidemic diarrhea virus RNA present in commercial spray-dried porcine plasma is not infectious to naïve pigsQ34035113
Distinct characteristics and complex evolution of PEDV strains, North America, May 2013-February 2014.Q34320942
Investigation into the role of potentially contaminated feed as a source of the first-detected outbreaks of porcine epidemic diarrhea in CanadaQ34805800
The dynamic distribution of porcine microbiota across different ages and gastrointestinal tract segmentsQ35092081
Investigating the introduction of porcine epidemic diarrhea virus into an Ohio swine operation.Q35101810
An evaluation of contaminated complete feed as a vehicle for porcine epidemic diarrhea virus infection of naïve pigs following consumption via natural feeding behavior: proof of conceptQ35219166
Aminopeptidase-N-independent entry of porcine epidemic diarrhea virus into Vero or porcine small intestine epithelial cells.Q52430575
Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin.Q52606324
Identification of porcine epidemic diarrhea virus variant with a large spike gene deletion from a clinical swine sample in the United States.Q52691126
New variants of porcine epidemic diarrhea virus with large deletions in the spike protein, identified in the United States, 2016-2017.Q54201730
Spillover of Swine Coronaviruses, United States.Q55651965
An alternative pathway of enteric PEDV dissemination from nasal cavity to intestinal mucosa in swineQ57017706
Better horizontal transmission of a US non-InDel strain compared with a French InDel strain of porcine epidemic diarrhoea virusQ57092513
Immunohistochemical detection of the vomiting-inducing monoamine neurotransmitter serotonin and enterochromaffin cells in the intestines of conventional or gnotobiotic (Gn) pigs infected with porcine epidemic diarrhea virus (PEDV) and serum cytokineQ57099667
An immunohistochemical investigation of porcine epidemic diarrhoeaQ57110131
Resistance to coronavirus infection in amino peptidase N-deficient pigsQ57473350
The Deletion of Both Tyrosine-Based Endocytosis Signal and Endoplasmic Reticulum-Retrieval Signal in the Cytoplasmic Tail of Spike Protein Attenuates PEDV in PigsQ58598666
Feed batch sequencing to decrease the risk of porcine epidemic diarrhea virus (PEDV) cross-contamination during feed manufacturingQ59354718
Stage of Gestation at Porcine Epidemic Diarrhea Virus Infection of Pregnant Swine Impacts Maternal Immunity and Lactogenic Immune Protection of Neonatal Suckling PigletsQ64093237
PEDV and PDCoV Pathogenesis: The Interplay Between Host Innate Immune Responses and Porcine Enteric CoronavirusesQ64111133
An apparently new syndrome of porcine epidemic diarrhoeaQ67602938
Contribution of the porcine aminopeptidase N (CD13) receptor density to porcine epidemic diarrhea virus infectionQ82517853
Coronavirus Endoribonuclease Activity in Porcine Epidemic Diarrhea Virus Suppresses Type I and Type III Interferon ResponsesQ84315380
Serological Screening for Coronavirus Infections in CatsQ84315543
Host Factors Affecting Generation of Immunity Against Porcine Epidemic Diarrhea Virus in Pregnant and Lactating Swine and Passive Protection of NeonatesQ89834330
The Role of Non-animal Origin Feed Ingredients in Transmission of Viral Pathogens of Swine: A Review of Scientific LiteratureQ90053827
Porcine Intestinal Enteroids: a New Model for Studying Enteric Coronavirus Porcine Epidemic Diarrhea Virus Infection and the Host Innate ResponseQ90435247
Limited shedding of an S-InDel strain of porcine epidemic diarrhea virus (PEDV) in semen and questions regarding the infectivity of the detected virusQ90795544
Characterization and pathogenicity of Vero cell-attenuated porcine epidemic diarrhea virus CT strainQ90984223
Two critical N-terminal epitopes of the nucleocapsid protein contribute to the cross-reactivity between porcine epidemic diarrhea virus and porcine transmissible gastroenteritis virusQ91086864
Emerging Highly Virulent Porcine Epidemic Diarrhea Virus: Molecular Mechanisms of Attenuation and Rational Design of Live Attenuated VaccinesQ91125814
Oral vitamin A supplementation of porcine epidemic diarrhea virus infected gilts enhances IgA and lactogenic immune protection of nursing pigletsQ91554285
Changes in cecal microbiota community of suckling piglets infected with porcine epidemic diarrhea virusQ91923452
Engineering a Live Attenuated Porcine Epidemic Diarrhea Virus Vaccine Candidate via Inactivation of the Viral 2'-O-Methyltransferase and the Endocytosis Signal of the Spike ProteinQ92225725
Aminopeptidase N Knockout Pigs Are Not Resistant to Porcine Epidemic Diarrhea Virus InfectionQ92330672
Virulence of current German PEDV strains in suckling pigs and investigation of protective effects of maternally derived antibodiesQ40052106
Effect of Booster Vaccination with Inactivated Porcine Epidemic Diarrhea Virus on Neutralizing Antibody Response in Mammary SecretionsQ40092227
Porcine aminopeptidase N is a functional receptor for the PEDV coronavirus.Q40139455
A New Bat-HKU2-like Coronavirus in Swine, China, 2017.Q40143972
Porcine epidemic diarrhea virus introduction into the United States: Root cause investigationQ40164547
Isolation and experimental inoculation of an S INDEL strain of porcine epidemic diarrhea virus in JapanQ40199410
Aminopeptidase N is not required for porcine epidemic diarrhea virus cell entryQ40264882
Attenuation of an original US porcine epidemic diarrhea virus strain PC22A via serial cell culture passageQ40296550
Reactivity of Porcine Epidemic Diarrhea Virus Structural Proteins to Antibodies against Porcine Enteric Coronaviruses: Diagnostic ImplicationsQ40331345
Goblet cell depletion in small intestinal villous and crypt epithelium of conventional nursing and weaned pigs infected with porcine epidemic diarrhea virusQ40346349
Super-oxidized water inactivates major viruses circulating in swine farmsQ40372295
Effect of Porcine Epidemic Diarrhea Virus Infectious Doses on Infection Outcomes in Naïve Conventional Neonatal and Weaned Pigs.Q40461602
Tissue localization, shedding, virus carriage, antibody response, and aerosol transmission of Porcine epidemic diarrhea virus following inoculation of 4-week-old feeder pigsQ40518454
iTRAQ-based comparative proteomic analysis of Vero cells infected with virulent and CV777 vaccine strain-like strains of porcine epidemic diarrhea virusQ40549186
Outbreak of Porcine Epidemic Diarrhea Virus in Portugal, 2015.Q40567868
Wild boars harboring porcine epidemic diarrhea virus (PEDV) may play an important role as a PEDV reservoir.Q40574798
Porcine aminopeptidase N is not a cellular receptor of porcine epidemic diarrhea virus, but promotes its infectivity via aminopeptidase activityQ40602610
Experimental Infection of Young Pigs with an Early European Strain of Porcine Epidemic Diarrhoea Virus and a Recent US Strain.Q40681528
Characterization of anti-porcine epidemic diarrhea virus neutralizing activity in mammary secretionsQ40707260
Pathogenesis comparison between the United States porcine epidemic diarrhoea virus prototype and S-INDEL-variant strains in conventional neonatal pigletsQ40806775
Transmissible gastroenteritis virus induces apoptosis in swine testicular cell lines but not in intestinal enterocytesQ40866999
Comparative Genomic Analysis of Classical and Variant Virulent Parental/Attenuated Strains of Porcine Epidemic Diarrhea VirusQ40932977
Age-dependent variation in innate immune responses to porcine epidemic diarrhea virus infection in suckling versus weaned pigsQ40967611
Characterization of Porcine Epidemic Diarrhea Virus Isolate US/Iowa/18984/2013 Infection in 1-Day-Old Cesarean-Derived Colostrum-Deprived PigletsQ41138695
Effects of disinfection on the molecular detection of porcine epidemic diarrhea virus.Q41162491
Effects of porcine epidemic diarrhea virus on porcine monocyte-derived dendritic cells and intestinal dendritic cellsQ41168812
Comparative pathogenesis of US porcine epidemic diarrhea virus (PEDV) strain PC21A in conventional 9-day-old nursing piglets vs. 26-day-old weaned pigsQ41260596
Structural alteration of tight and adherens junctions in villous and crypt epithelium of the small and large intestine of conventional nursing piglets infected with porcine epidemic diarrhea virusQ41354454
Pathogenicity of 2 porcine deltacoronavirus strains in gnotobiotic pigsQ41381727
Detection and genetic characterization of deltacoronavirus in pigs, Ohio, USA, 2014.Q41389118
Previous infection of sows with a "mild" strain of porcine epidemic diarrhea virus confers protection against infection with a "severe" strainQ41533664
Antigenic relationships among porcine epidemic diarrhea virus and transmissible gastroenteritis virus strainsQ41544428
Pathogenesis of porcine epidemic diarrhea virus isolate (US/Iowa/18984/2013) in 3-week-old weaned pigs.Q41718074
Cross protective immune responses in nursing piglets infected with a US spike-insertion deletion porcine epidemic diarrhea virus strain and challenged with an original US PEDV strain.Q41922727
Quantitation, biological and physicochemical properties of cell culture-adapted porcine epidemic diarrhea coronavirus (PEDV).Q42113947
Evidence of infectivity of airborne porcine epidemic diarrhea virus and detection of airborne viral RNA at long distances from infected herdsQ42206382
Porcine epidemic diarrhea virus induces caspase-independent apoptosis through activation of mitochondrial apoptosis-inducing factorQ42206741
Emergence of Porcine epidemic diarrhea virus in the United States: clinical signs, lesions, and viral genomic sequencesQ42250492
New variant of porcine epidemic diarrhea virus, United States, 2014.Q42558554
PEDV ORF3 encodes an ion channel protein and regulates virus production.Q42632084
Completion of the porcine epidemic diarrhoea coronavirus (PEDV) genome sequenceQ42664565
Evaluation of porcine epidemic diarrhea virus transmission and the immune response in growing pigsQ35568850
Receptor usage and cell entry of porcine epidemic diarrhea coronavirusQ35641223
Emergence of porcine epidemic diarrhea virus in southern GermanyQ35681120
Complete genome sequence of a porcine epidemic diarrhea s gene indel strain isolated in france in december 2014.Q35687201
Changes in the Swine Gut Microbiota in Response to Porcine Epidemic Diarrhea InfectionQ35714791
Concentration, Size Distribution, and Infectivity of Airborne Particles Carrying Swine VirusesQ35750060
Porcine Epidemic Diarrhea Virus Infection Induced the Unbalance of Gut Microbiota in PigletsQ35759696
A Porcine Epidemic Diarrhea Virus Outbreak in One Geographic Region of the United States: Descriptive Epidemiology and Investigation of the Possibility of Airborne Virus SpreadQ35879333
Determination of the infectious titer and virulence of an original US porcine epidemic diarrhea virus PC22A strainQ36091931
Experimental infection of a US spike-insertion deletion porcine epidemic diarrhea virus in conventional nursing piglets and cross-protection to the original US PEDV infectionQ36304203
Evaluation of biosecurity measures to prevent indirect transmission of porcine epidemic diarrhea virusQ36337272
Porcine epidemic diarrhea virus: An emerging and re-emerging epizootic swine virusQ36393643
First detection, clinical presentation and phylogenetic characterization of Porcine epidemic diarrhea virus in AustriaQ36416857
Porcine Epidemic Diarrhea Virus and Discovery of a Recombinant Swine Enteric Coronavirus, Italy.Q36418103
Evaluation of humoral immune status in porcine epidemic diarrhea virus (PEDV) infected sows under field conditionsQ36424830
Characterization of a Pathogenic Full-Length cDNA Clone and Transmission Model for Porcine Epidemic Diarrhea Virus Strain PC22AQ36496511
Pathology of Experimental CV777 Coronavirus Enteritis in Piglets. I. Histological and Histochemical StudyQ36596266
Identification and Comparison of Receptor Binding Characteristics of the Spike Protein of Two Porcine Epidemic Diarrhea Virus StrainsQ36735622
Evaluation of serological cross-reactivity and cross-neutralization between the United States porcine epidemic diarrhea virus prototype and S-INDEL-variant strainsQ36765494
Origin, evolution, and genotyping of emergent porcine epidemic diarrhea virus strains in the United StatesQ37267066
Increased frequency of porcine epidemic diarrhea virus shedding and lesions in suckling pigs compared to nursery pigs and protective immunity in nursery pigs after homologous re-challengeQ37428407
Isolation and characterization of porcine epidemic diarrhea viruses associated with the 2013 disease outbreak among swine in the United StatesQ37546560
Pathology of US porcine epidemic diarrhea virus strain PC21A in gnotobiotic pigsQ37664587
Porcine epidemic diarrhea virus infection: Etiology, epidemiology, pathogenesis and immunoprophylaxisQ38405642
Oral efficacy of Vero cell attenuated porcine epidemic diarrhea virus DR13 strainQ38510073
Tight Junction Protein Occludin Is a Porcine Epidemic Diarrhea Virus Entry FactorQ38713034
Two-way antigenic cross-reactivity between porcine epidemic diarrhea virus and porcine deltacoronavirusQ38782985
Vaccines for porcine epidemic diarrhea virus and other swine coronavirusesQ38783240
Deletion of a 197-Amino-Acid Region in the N-Terminal Domain of Spike Protein Attenuates Porcine Epidemic Diarrhea Virus in PigletsQ38793703
Porcine deltacoronavirus induces apoptosis in swine testicular and LLC porcine kidney cell lines in vitro but not in infected intestinal enterocytes in vivoQ38808478
A new coronavirus-like particle associated with diarrhea in swineQ39522937
Pig epidemic diarrhoea virus S gene variant with a large deletion non-lethal to colostrum-deprived newborn pigletsQ39735491
Porcine epidemic diarrhea virus does not replicate in porcine monocyte-derived dendritic cells, but activates the transcription of type I interferon and chemokineQ40049463
Cellular cholesterol is required for porcine nidovirus infection.Q40051639
P6216copyright statuscopyrightedQ50423863
P921main subjectintestinal epitheliumQ509615
porcine epidemic diarrhea virusQ16023751
coronavirus diseaseQ18975243
swine diseaseQ54947664
P304page(s)198045
P577publication date2020-06-02
2020-09-01
P1433published inVirus ResearchQ15749215
P1476titlePorcine epidemic diarrhea virus (PEDV): An update on etiology, transmission, pathogenesis, and prevention and control

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