Holding CoVID in check through JAK? The MPN-approved compound ruxolitinib as a potential strategy to treat SARS-CoV-2 induced systemic hyperinflammation

scientific article published on 11 June 2020

Holding CoVID in check through JAK? The MPN-approved compound ruxolitinib as a potential strategy to treat SARS-CoV-2 induced systemic hyperinflammation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/S41375-020-0898-6
P698PubMed publication ID32528040

P2093author name stringA Hochhaus
F Heidel
P2860cites workA double-blind, placebo-controlled trial of ruxolitinib for myelofibrosisQ33399980
Ruxolitinib versus standard therapy for the treatment of polycythemia vera.Q33420037
Myeloproliferative neoplasms and inflammation: whether to target the malignant clone or the inflammatory process or bothQ38725723
Impact of tofacitinib treatment on human B-cells in vitro and in vivoQ39237235
JAK1/2 inhibition impairs T cell function in vitro and in patients with myeloproliferative neoplasmsQ41138516
JAK inhibition induces silencing of T Helper cytokine secretion and a profound reduction in T regulatory cellsQ41160178
Rapid and long-lasting decrease of T-regulatory cells in patients with myelofibrosis treated with ruxolitinib.Q46891342
Specificity of JAK-kinase inhibition determines impact on human and murine T-cell function.Q54254821
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, ChinaQ83767469
Activity of therapeutic JAK 1/2 blockade in graft-versus-host diseaseQ87635679
Ruxolitinib in adult patients with secondary haemophagocytic lymphohistiocytosis: an open-label, single-centre, pilot trialQ90181685
Mechanisms of action of ruxolitinib in murine models of hemophagocytic lymphohistiocytosisQ90249953
JAK2-V617F promotes venous thrombosis through β1/β2 integrin activationQ90340948
Roles of JAK2 in Aging, Inflammation, Hematopoiesis and Malignant TransformationQ92528596
Long-term efficacy and safety of ruxolitinib versus best available therapy in polycythaemia vera (RESPONSE): 5-year follow up of a phase 3 studyQ92940643
Ruxolitinib for Glucocorticoid-Refractory Acute Graft-versus-Host DiseaseQ93152425
HiJAKing SARS-CoV-2? The potential role of JAK inhibitors in the management of COVID-19Q94568423
An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort studyQ94919190
Impaired type I interferon activity and exacerbated inflammatory responses in severe Covid-19 patientsQ95603823
Frequency of infections in 948 MPN patients: a prospective multicenter patient-reported pilot studyQ96032684
SARS-CoV-2 infection and overactivation of Nlrp3 inflammasome as a trigger of cytokine "storm" and risk factor for damage of hematopoietic stem cellsQ96127261
The Janus kinase 1/2 inhibitor ruxolitinib in COVID-19 with severe systemic hyperinflammationQ96230236
P921main subjectruxolitinibQ7383611
SARS-CoV-2Q82069695
P577publication date2020-06-11
P1433published inLeukemiaQ6534498
P1476titleHolding CoVID in check through JAK? The MPN-approved compound ruxolitinib as a potential strategy to treat SARS-CoV-2 induced systemic hyperinflammation