Knock-out of Hopx disrupts stemness and quiescence of hematopoietic stem cells in mice

scientific article published on 12 June 2020

Knock-out of Hopx disrupts stemness and quiescence of hematopoietic stem cells in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41388-020-1340-2
P698PubMed publication ID32533098

P50authorWen-Chien ChouQ57006865
Tien Hwei-fangQ57006900
Yu-Chiao ChiuQ61097094
Chien-Chin LinQ86531194
Yueh-Chwen HsuQ92507332
Chein-Jun KaoQ114422813
P2093author name stringYi-Hung Li
Yidong Chen
Hsin-An Hou
Chang-Tsu Yuan
Chi-Yuan Yao
Po-Han Chuang
P2860cites workGfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cellsQ45085155
Intestinal label-retaining cells are secretory precursors expressing Lgr5.Q45481109
Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells.Q51275474
Hematopoietic stem cell quiescence maintained by p21cip1/waf1Q73532192
Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and BiomechanicsQ92420783
Phf6-null hematopoietic stem cells have enhanced self-renewal capacity and oncogenic potentialsQ92507334
Mesenchymal Niche-Specific Expression of Cxcl12 Controls Quiescence of Treatment-Resistant Leukemia Stem CellsQ92579727
A Common Embryonic Origin of Stem Cells Drives Developmental and Adult NeurogenesisQ92726604
Quiescence: Good and Bad of Stem Cell AgingQ93085735
Hematopoietic stem cell niche maintenance during homeostasis and regenerationQ26865273
CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia MaintenanceQ27324358
Hop is an unusual homeobox gene that modulates cardiac developmentQ28203645
Analysis of the structure and function of the transcriptional coregulator HOPQ28260660
Modulation of cardiac growth and development by HOP, an unusual homeodomain proteinQ28507581
Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesisQ29615762
CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrowQ30608356
Homeobox gene HOPX is epigenetically silenced in human uterine endometrial cancer and suppresses estrogen-stimulated proliferation of cancer cells by inhibiting serum response factorQ33403307
Higher HOPX expression is associated with distinct clinical and biological features and predicts poor prognosis in de novo acute myeloid leukemiaQ33746724
Loss of Cxcl12/Sdf-1 in adult mice decreases the quiescent state of hematopoietic stem/progenitor cells and alters the pattern of hematopoietic regeneration after myelosuppressionQ34137483
Nice neighborhood: emerging concepts of the stem cell nicheQ34165273
A reserve stem cell population in small intestine renders Lgr5-positive cells dispensableQ34217232
Interconversion between intestinal stem cell populations in distinct nichesQ34231718
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markersQ34280882
The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotypeQ34294149
The aged niche disrupts muscle stem cell quiescence.Q34302715
Cancer specific promoter CpG Islands hypermethylation of HOP homeobox (HOPX) gene and its potential tumor suppressive role in pancreatic carcinogenesisQ34408593
Prospective identification and purification of quiescent adult neural stem cells from their in vivo nicheQ35180108
Epigenetic silencing of HOPX promotes cancer progression in colorectal cancerQ36172719
CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironmentQ36306137
Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cellsQ36752936
HOPX hypermethylation promotes metastasis via activating SNAIL transcription in nasopharyngeal carcinomaQ37630359
Cell of origin in AML: susceptibility to MN1-induced transformation is regulated by the MEIS1/AbdB-like HOX protein complexQ38262122
Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung.Q39626274
Potential utility of HOP homeobox gene promoter methylation as a marker of tumor aggressiveness in gastric cancerQ39727817
HOP/OB1/NECC1 promoter DNA is frequently hypermethylated and involved in tumorigenic ability in esophageal squamous cell carcinomaQ40018700
Homeobox gene HOP has a potential tumor suppressive activity in human lung cancerQ40148089
Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive HematopoiesisQ41559939
The Genetic Landscape of Hematopoietic Stem Cell Frequency in MiceQ41984817
CXCR4 is required for the quiescence of primitive hematopoietic cellsQ42090614
CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenanceQ43226905
P921main subjectstem-cell quiescenceQ125311828
P577publication date2020-06-12
P1433published inOncogeneQ1568657
P1476titleKnock-out of Hopx disrupts stemness and quiescence of hematopoietic stem cells in mice

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