An Insight into the Sex Differences in COVID-19 Patients: What are the Possible Causes?

scientific article published on 18 June 2020

An Insight into the Sex Differences in COVID-19 Patients: What are the Possible Causes? is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1017/S1049023X20000837
P932PMC publication ID7327162
P698PubMed publication ID32600476

P50authorJamal HallajzadehQ94566734
P2093author name stringZatollah Asemi
Mohammad Ali Mansournia
Bahman Yousefi
Mansooreh Momen-Heravi
Fatemeh Sadoughi
Parisa Maleki Dana
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TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike proteinQ24339582
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Structure of SARS coronavirus spike receptor-binding domain complexed with receptorQ34451350
Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune responseQ35076795
The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis.Q35224818
Androgen receptor influences on body defense system via modulation of innate and adaptive immune systems: lessons from conditional AR knockout miceQ36355602
Modulation of TNF-alpha-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-alpha production and facilitates viral entryQ36693984
Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection.Q38857463
Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: a positive feedback mechanism in the RAS.Q39044195
Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2.Q42844863
Do men have a higher case fatality rate of severe acute respiratory syndrome than women do?Q47244472
Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic targetQ88291889
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease InhibitorQ88292103
The relationship between circulating testosterone and inflammatory cytokines in menQ89168700
Clinical Advances in Sex- and Gender-Informed Medicine to Improve the Health of All: A ReviewQ89627718
Immediate Psychological Responses and Associated Factors during the Initial Stage of the 2019 Coronavirus Disease (COVID-19) Epidemic among the General Population in ChinaQ90189664
Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective studyQ90688501
The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from ChinaQ90720693
Disparities in Age-Specific Morbidity and Mortality from SARS-CoV-2 in China and the Republic of KoreaQ90783903
Prevalence and predictors of PTSS during COVID-19 outbreak in China hardest-hit areas: Gender differences matterQ91513013
SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cellsQ91561671
TMPRSS2 and COVID-19: Serendipity or opportunity for intervention?Q91815388
Sex-Specific SARS-CoV-2 Mortality: Among Hormone-Modulated ACE2 Expression, Risk of Venous Thromboembolism and Hypovitaminosis DQ93211345
Sex-specific clinical characteristics and prognosis of coronavirus disease-19 infection in Wuhan, China: A retrospective study of 168 severe patientsQ94445846
Clinical and Epidemiological Characteristics of 1,420 European Patients with mild-to-moderate Coronavirus Disease 2019Q94466261
Testosterone, a key hormone in the context of COVID-19 pandemicQ94469424
Radiographic severity index in COVID-19 pneumonia: relationship to age and sex in 783 Italian patientsQ94484526
Sex and Gender Differences in Health: What the COVID-19 Pandemic Can Teach UsQ94563776
Transcriptional landscape of SARS-CoV-2 infection dismantles pathogenic pathways activated by the virus, proposes unique sex-specific differences and predicts tailored therapeutic strategiesQ94588809
Age and sex differences in soluble ACE2 may give insights for COVID-19Q94918222
Gender Differences in Patients With COVID-19: Focus on Severity and MortalityQ94926165
Low testosterone levels predict clinical adverse outcomes in SARS-CoV-2 pneumonia patientsQ95278344
Prevalence of depression, anxiety, and insomnia among healthcare workers during the COVID-19 pandemic: A systematic review and meta-analysisQ95298015
COVID-19 and Individual Genetic Susceptibility/Receptivity: Role of ACE1/ACE2 Genes, Immunity, Inflammation and Coagulation. Might the Double X-chromosome in Females Be Protective against SARS-CoV-2 Compared to the Single X-Chromosome in Males?Q95307667
Estrogen regulates the expression of SARS-CoV-2 receptor ACE2 in differentiated airway epithelial cellsQ95311584
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectCOVID-19Q84263196
P304page(s)1-4
P577publication date2020-06-18
P1433published inPrehospital and Disaster MedicineQ15758348
P1476titleAn Insight into the Sex Differences in COVID-19 Patients: What are the Possible Causes?

Reverse relations

cites work (P2860)
Q101409822Age-severity matched cytokine profiling reveals specific signatures in Covid-19 patients
Q110013316SARS-CoV-2 Spike Protein S1-Mediated Endothelial Injury and Pro-Inflammatory State Is Amplified by Dihydrotestosterone and Prevented by Mineralocorticoid Antagonism
Q99612915SARS-CoV-2 and the possible connection to ERs, ACE2, and RAGE: Focus on susceptibility factors

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