Combined optimization of N-terminal site-specific PEGylation of recombinant hirudin using response surface methodology and kinetic analysis

scientific article published on 05 June 2018

Combined optimization of N-terminal site-specific PEGylation of recombinant hirudin using response surface methodology and kinetic analysis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/ELSC.201700190
P932PMC publication ID6999329
P698PubMed publication ID32624941

P2093author name stringXudong Wang
Yundong Sun
Zhilong Xiu
Fengying Zhang
Kairong Qin
Duotao Pan
Shuchang Wang
Hengli Yuan
P2860cites workThe structure of a complex of recombinant hirudin and human alpha-thrombinQ27684792
36 Automated edman degradation: The protein sequenatorQ28245494
Treatment of heparin-induced thrombocytopeniaQ31042575
Bivalent direct thrombin inhibitors: hirudin and bivalirudinQ33361074
The direct thrombin inhibitor hirudinQ33379453
Optimization of PEGylation conditions for BSA nanoparticles using response surface methodologyQ34280232
Production and clinical development of a Hansenula polymorpha-derived PEGylated hirudin.Q34362567
The pharmacology of PEGylation: balancing PD with PK to generate novel therapeuticsQ37058806
Process for protein PEGylationQ38188369
PEGylation of Biopharmaceuticals: A Review of Chemistry and Nonclinical Safety Information of Approved DrugsQ38730623
Solid-phase N-terminus PEGylation of recombinant human fibroblast growth factor 2 on heparin-sepharose columnQ42798062
Response surface optimization of experimental conditions for carbamazepine biodegradation by Streptomyces MIUG 4.89.Q43327845
Enhanced production of 2,3-butanediol from sugarcane molassesQ50283983
Construction and functional evaluation of hirudin derivatives with low bleeding risk.Q53497899
Biochemical and pharmacokinetic characterisation of two PEGylated variants of dipetarudinQ84492408
Optimization of phenol degradation by the microalga Chlorella pyrenoidosa using Plackett-Burman Design and Response Surface MethodologyQ87295152
Investigation by response surface methodology of the combined effect of pH and composition of water-methanol mixtures on the stability of curcuminoidsQ88597415
P4510describes a project that usesresponse surface methodologyQ3136137
P433issue8
P921main subjecthirudinQ386715
P304page(s)611-621
P577publication date2018-06-05
P1433published inEngineering in Life SciencesQ15752832
P1476titleCombined optimization of N-terminal site-specific PEGylation of recombinant hirudin using response surface methodology and kinetic analysis
P478volume18

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