Expression of Chitotriosidase in Macrophages Modulates Atherosclerotic Plaque Formation in Hyperlipidemic Mice

scientific article published on 23 June 2020

Expression of Chitotriosidase in Macrophages Modulates Atherosclerotic Plaque Formation in Hyperlipidemic Mice is …
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scholarly articleQ13442814

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P356DOI10.3389/FPHYS.2020.00714
P932PMC publication ID7324766
P698PubMed publication ID32655419

P50authorBog-Hieu LeeQ113298190
P2093author name stringWilliam A Boisvert
Jonathan Yap
Sara McCurdy
Martin Alcala
Shiro Kitamoto
Jan Garo
Jason Irei
Whitney Regan
P2860cites workCD44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and -2Q24336714
NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responsesQ24670080
Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and CancerQ27021261
Requisite role for interleukin-4 in the acceleration of fatty streaks induced by heat shock protein 65 or Mycobacterium tuberculosis.Q52539711
Suppressor of cytokine signaling (SOCS)1 is a key determinant of differential macrophage activation and function.Q53243987
Vulnerable atherosclerotic plaque metalloproteinases and foam cell phenotypes.Q55605575
Granulocyte colony-stimulating factor downregulates allogeneic immune responses by posttranscriptional inhibition of tumor necrosis factor-alpha productionQ71708587
Fibrillar collagen inhibits arterial smooth muscle proliferation through regulation of Cdk2 inhibitorsQ71934600
Interleukin-8. A mitogen and chemoattractant for vascular smooth muscle cellsQ72018966
Synthesis, sorting, and processing into distinct isoforms of human macrophage chitotriosidaseQ73268203
IL-8 is an angiogenic factor in human coronary atherectomy tissueQ73624327
Extracellular matrix modulates macrophage functions characteristic to atheroma: collagen type I enhances acquisition of resident macrophage traits by human peripheral blood monocytes in vitroQ74351464
Differential regulation of CD44 expression by lipopolysaccharide (LPS) and TNF-alpha in human monocytic cells: distinct involvement of c-Jun N-terminal kinase in LPS-induced CD44 expressionQ78489000
Serum chitotriosidase activity in patients with coronary artery diseaseQ80408400
G-CSF prevents the progression of atherosclerosis and neointimal formation in rabbitsQ83114414
Hyaluronic acid metabolism is increased in unstable plaquesQ84515129
Purification and characterization of human chitotriosidase, a novel member of the chitinase family of proteinsQ28118880
Selective inhibition of PI3K/Akt/mTOR signaling pathway regulates autophagy of macrophage and vulnerability of atherosclerotic plaqueQ31152970
TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathwayQ31858969
Human Chitotriosidase: Catalytic Domain or Carbohydrate Binding Module, Who's Leading HCHT's Biological FunctionQ33765805
Effects of G-CSF on serum cholesterol and development of atherosclerotic plaque in apolipoprotein E-deficient miceQ34167012
SOCS3 deficiency promotes M1 macrophage polarization and inflammation.Q34287544
Chitin--the undisputed biomolecule of great potential.Q35066978
Up-regulated expression of the CXCR2 ligand KC/GRO-alpha in atherosclerotic lesions plays a central role in macrophage accumulation and lesion progression.Q35088170
Chitinase 1 is a biomarker for and therapeutic target in scleroderma-associated interstitial lung disease that augments TGF-β1 signalingQ35108749
Chitotriosidase gene expression in Kupffer cells from patients with non-alcoholic fatty liver diseaseQ35768951
The role of interleukin-4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient miceQ35792034
Functions of miR-146a and miR-222 in Tumor-associated Macrophages in Breast CancerQ36392725
Hyaluronidases: their genomics, structures, and mechanisms of actionQ36415698
Chitinase inhibition promotes atherosclerosis in hyperlipidemic mice.Q36986505
Metalloproteinase expression in monocytes and macrophages and its relationship to atherosclerotic plaque instabilityQ37261160
A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient miceQ37377448
Evidence for a role of collagen synthesis in arterial smooth muscle cell migrationQ37381419
Cells expressing the DG42 gene from early Xenopus embryos synthesize hyaluronanQ37596818
Homologs of the Xenopus developmental gene DG42 are present in zebrafish and mouse and are involved in the synthesis of Nod-like chitin oligosaccharides during early embryogenesisQ37597054
Formation of hyaluronan- and versican-rich pericellular matrix is required for proliferation and migration of vascular smooth muscle cellsQ38326238
Carbohydrate binding specificity of the recombinant chitin-binding domain of human macrophage chitinaseQ38347371
Hyaluronic Acid in Inflammation and Tissue RegenerationQ38775473
Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugsQ38793764
miR-146a Mediates Protective Innate Immune Tolerance in the Neonate IntestineQ39643377
Akt- and MAPK-mediated activation and secretion of MMP-9 into stroma in breast cancer cells upon heregulin treatment.Q40029865
Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells.Q40216222
CD44 is a phagocytic receptorQ40321240
In vitro biomarker discovery for atherosclerosis by proteomicsQ40501649
The hyaluronan receptor (CD44) participates in the uptake and degradation of hyaluronanQ41642217
ERK Is Integral to the IFN-γ–Mediated Activation of STAT1, the Expression of Key Genes Implicated in Atherosclerosis, and the Uptake of Modified Lipoproteins by Human MacrophagesQ42950247
Appropriate doses of granulocyte-colony stimulating factor reduced atherosclerotic plaque formation and increased plaque stability in cholesterol-fed rabbitsQ43191696
Interleukin-4 deficiency decreases atherosclerotic lesion formation in a site-specific manner in female LDL receptor-/- miceQ43909351
Interleukin-8 as a macrophage-derived mediator of angiogenesisQ44053300
Granulocyte colony-stimulating factor promotes the generation of regulatory DC through induction of IL-10 and IFN-alpha.Q47682169
Serum chitotriosidase activity is increased in subjects with atherosclerosis diseaseQ48237551
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P304page(s)714
P577publication date2020-06-23
P1433published inFrontiers in PhysiologyQ2434141
P1476titleExpression of Chitotriosidase in Macrophages Modulates Atherosclerotic Plaque Formation in Hyperlipidemic Mice
P478volume11

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