Sacubitril/Valsartan in Advanced Heart Failure With Reduced Ejection Fraction: Rationale and Design of the LIFE Trial

scientific article published on 10 June 2020

Sacubitril/Valsartan in Advanced Heart Failure With Reduced Ejection Fraction: Rationale and Design of the LIFE Trial is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.JCHF.2020.05.005
P932PMC publication ID7286640
P698PubMed publication ID32641226

P50authorMargaret M RedfieldQ98243295
P2093author name stringDouglas L Mann
Gregory D Lewis
Divya Gupta
Adam D DeVore
Adrian F Hernandez
Eugene Braunwald
Randall C Starling
Michael M Givertz
Patrice Desvigne-Nickens
Stephen J Greene
Eiran Z Gorodeski
Selma F Mohammed
LIFE Investigators
Andrew P Ambrosy
Claudius Mahr
Steven E McNulty
Palak Shah
Justin M Vader
Anuradha Lala
Nisha A Gilotra
P2860cites workOutcomes with ambulatory advanced heart failure from the Medical Arm of Mechanically Assisted Circulatory Support (MedaMACS) RegistryQ92857637
Angiotensin-Neprilysin Inhibition in Heart Failure with Preserved Ejection FractionQ93053031
Estimated 5-Year Number Needed to Treat to Prevent Cardiovascular Death or Heart Failure Hospitalization With Angiotensin Receptor-Neprilysin Inhibition vs Standard Therapy for Patients With Heart Failure With Reduced Ejection Fraction: An AnalysisQ93365428
Advanced (stage D) heart failure: a statement from the Heart Failure Society of America Guidelines CommitteeQ95723047
Angiotensin-neprilysin inhibition versus enalapril in heart failureQ28247091
Combination of isosorbide dinitrate and hydralazine in blacks with heart failureQ28292266
The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study InvestigatorsQ28372091
2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice GuidelinesQ29620107
Effect of oral milrinone on mortality in severe chronic heart failure. The PROMISE Study Research GroupQ33157410
Effect of carvedilol on survival in severe chronic heart failureQ33949292
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contributQ34527664
Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS).Q34682919
Baseline characteristics and treatment of patients in prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in heart failure trial (PARADIGM-HF).Q35035016
Factors Associated With Noncompletion During the Run-In Period Before Randomization and Influence on the Estimated Benefit of LCZ696 in the PARADIGM-HF TrialQ38391338
Oral levosimendan in patients with severe chronic heart failure --the PERSIST studyQ38572099
Long-Term Effects of Flosequinan on the Morbidity and Mortality of Patients With Severe Chronic Heart Failure: Primary Results of the PROFILE Trial After 24 YearsQ38787758
The win ratio: a new approach to the analysis of composite endpoints in clinical trials based on clinical prioritiesQ39361032
Effects of low-dose oral enoximone administration on mortality, morbidity, and exercise capacity in patients with advanced heart failure: the randomized, double-blind, placebo-controlled, parallel group ESSENTIAL trialsQ41859441
Safety and efficacy of carvedilol in severe heart failure. The U.S. Carvedilol Heart Failure Study GroupQ42547184
Effect of amlodipine on the survival of patients with severe chronic heart failure due to a nonischemic cardiomyopathy: results of the PRAISE-2 study (prospective randomized amlodipine survival evaluation 2).Q43723547
Low-dose oral enoximone enhances the ability to wean patients with ultra-advanced heart failure from intravenous inotropic support: results of the oral enoximone in intravenous inotrope-dependent subjects trialQ44732752
The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trialQ48395213
Outpatient Worsening Heart Failure as a Target for Therapy: A ReviewQ49506557
Estimating the Long-Term Treatment Benefits of Sacubitril–ValsartanQ57396161
Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to Determine IQ57396192
2016 ACC/AHA/HFSA Focused Update on New Pharmacological Therapy for Heart Failure: An Update of the 2013 ACCF/AHA Guideline for the Management of Heart FailureQ57629858
Outpatient versus inpatient worsening heart failure: distinguishing biology and risk from location of careQ58610156
Angiotensin–Neprilysin Inhibition in Acute Decompensated Heart FailureQ61795227
Xamoterol in severe heart failure. The Xamoterol in Severe Heart Failure Study GroupQ67663743
Long-term oral administration of amrinone for congestive heart failure: lack of efficacy in a multicenter controlled trialQ69888770
Effect of amlodipine on morbidity and mortality in severe chronic heart failure. Prospective Randomized Amlodipine Survival Evaluation Study GroupQ71545362
Randomised study of effect of ibopamine on survival in patients with advanced severe heart failure. Second Prospective Randomised Study of Ibopamine on Mortality and Efficacy (PRIME II) InvestigatorsQ73217048
2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society oQ87967845
Vericiguat in Patients with Heart Failure and Reduced Ejection FractionQ90718817
P921main subjectejection fractionQ641303
heart failure with reduced ejection fractionQ56218018
P577publication date2020-06-10
P1433published inJACC: Heart FailureQ26841917
P1476titleSacubitril/Valsartan in Advanced Heart Failure With Reduced Ejection Fraction: Rationale and Design of the LIFE Trial

Reverse relations

Q104074388Novel doses of sacubitril/valsartan in patients unable to tolerate traditional therapy: Effects on N-terminal pro B-type natriuretic peptide levelscites workP2860

Search more.