Fisetin alleviates sepsis-induced multiple organ dysfunction in mice via inhibiting p38 MAPK/MK2 signaling

scientific article published on 13 July 2020

Fisetin alleviates sepsis-induced multiple organ dysfunction in mice via inhibiting p38 MAPK/MK2 signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41401-020-0462-Y
P932PMC publication ID7608145
P698PubMed publication ID32661350

P2093author name stringFeng Qian
Hai-Feng Zhang
Hai-Bo Zhang
Wei-Dong Cheng
Xue-Ping Wu
Ya-Ling Guo
P2860cites workThe role of pattern-recognition receptors in innate immunity: update on Toll-like receptorsQ27860900
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Sepsis, complement and the dysregulated inflammatory responseQ37590899
Selective iNOS inhibition for the treatment of sepsis-induced acute kidney injuryQ37604884
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CD169⁺ macrophages provide a niche promoting erythropoiesis under homeostasis and stressQ37698517
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Fisetin inhibits cellular proliferation and induces mitochondria-dependent apoptosis in human gastric cancer cellsQ38766987
Post-Translational Modifications of the TAK1-TAB Complex.Q39096576
Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization.Q39099628
Stercurensin inhibits nuclear factor-κB-dependent inflammatory signals through attenuation of TAK1-TAB1 complex formationQ39602471
p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infectionQ41355717
Determination of the safety and efficacy of therapeutic neutralization of tumor necrosis factor-α (TNF-α) using AZD9773, an anti-TNF-α immune Fab, in murine CLP sepsisQ45895881
Protective Effects of Fisetin Against 6-OHDA-Induced Apoptosis by Activation of PI3K-Akt Signaling in Human Neuroblastoma SH-SY5Y CellsQ46248167
Fisetin as a caloric restriction mimetic protects rat brain against aging induced oxidative stress, apoptosis and neurodegenerationQ47622689
MK2 balances inflammation and cell deathQ47727789
TAK1 adaptor proteins, TAB2 and TAB3, link the signalosome to B-cell receptor-induced IKK activationQ48124315
TLR4 Signaling Pathway Modulators as Potential Therapeutics in Inflammation and SepsisQ48641496
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Macrophages and the Recovery from Acute and Chronic Inflammation.Q51270292
Indirubin Inhibits LPS-Induced Inflammation via TLR4 Abrogation Mediated by the NF-kB and MAPK Signaling Pathways.Q51415249
Targeting macrophage immunometabolism: Dawn in the darkness of sepsis.Q52602147
Fisetin Exerts Antioxidant and Neuroprotective Effects in Multiple Mutant hSOD1 Models of Amyotrophic Lateral Sclerosis by Activating ERK.Q52646216
Anti-septic effects of fisetin in vitro and in vivo.Q52649154
MK2 mediates macrophage activation and acute lung injury by regulating let-7e miRNA.Q54109229
Curcumin's Metabolites, Tetrahydrocurcumin and Octahydrocurcumin, Possess Superior Anti-inflammatory Effects Through Suppression of TAK1-NF-κB PathwayQ58606486
Fisetin inhibits the generation of inflammatory mediators in interleukin-1β–induced human lung epithelial cells by suppressing the NF-κB and ERK1/2 pathwaysQ58674403
Nrf2⁻ARE Signaling Acts as Master Pathway for the Cellular Antioxidant Activity of FisetinQ64260068
Fisetin, an inhibitor of cyclin-dependent kinase 6, down-regulates nuclear factor-kappaB-regulated cell proliferation, antiapoptotic and metastatic gene products through the suppression of TAK-1 and receptor-interacting protein-regulated IkappaBalphQ80043880
Regulated cell death and inflammation: an auto-amplification loop causes organ failureQ85817618
Costunolide alleviates HKSA-induced acute lung injury via inhibition of macrophage activationQ91050096
Intracellular synthesis of gold nanoparticles by Gluconacetobacter liquefaciens for delivery of peptide CopA3 and ginsenoside and anti-inflammatory effect on lipopolysaccharide-activated macrophagesQ92057185
α-Mangostin suppresses NLRP3 inflammasome activation via promoting autophagy in LPS-stimulated murine macrophages and protects against CLP-induced sepsis in miceQ92709750
P4510describes a project that usesImageJQ1659584
P921main subjectfisetinQ418384
P577publication date2020-07-13
P1433published inActa Pharmacologica SinicaQ15749885
P1476titleFisetin alleviates sepsis-induced multiple organ dysfunction in mice via inhibiting p38 MAPK/MK2 signaling

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