PIM2 promotes hepatocellular carcinoma tumorigenesis and progression through activating NF-κB signaling pathway

scientific article published on 02 July 2020

PIM2 promotes hepatocellular carcinoma tumorigenesis and progression through activating NF-κB signaling pathway is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41419-020-2700-0
P932PMC publication ID7343807
P698PubMed publication ID32641749

P50authorXin-Yuan GuanQ39845550
Yunfei YuanQ40548428
Jian-Dong HuangQ70624280
Jinna ChenQ96128102
Lingxi JiangQ97533874
P2093author name stringYun Zhu
Shuo Fang
Tengfei Liu
Tingting Cao
Liyi Zhang
Xiaoyan Ming
Xuming Tang
P2860cites workRIP2 is a novel NF-kappaB-activating and cell death-inducing kinaseQ24310179
The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell deathQ28204906
Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activationQ28293962
The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitorQ28508632
Nuclear factor-kappaB in cancer development and progressionQ29547879
Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expressionQ29615766
Epidemiology of viral hepatitis and hepatocellular carcinomaQ29617918
PIM2 Induced COX-2 and MMP-9 expression in macrophages requires PI3K and Notch1 signalingQ33418594
PIM kinase inhibitor AZD1208 for treatment of MYC-driven prostate cancerQ35078578
The Pim kinases control rapamycin-resistant T cell survival and activationQ36402605
Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinomaQ37198014
Positive feedback between NF-κB and TNF-α promotes leukemia-initiating cell capacityQ37524210
AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemiaQ37564783
Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylationQ38266874
Loss of PIM2 enhances the anti-proliferative effect of the pan-PIM kinase inhibitor AZD1208 in non-Hodgkin lymphomas.Q38813901
PIM2 kinase is induced by cisplatin in ovarian cancer cells and limits drug efficacyQ38968271
Pim-2 kinase is an important target of treatment for tumor progression and bone loss in myeloma.Q38999733
Allele-specific imbalance of oxidative stress-induced growth inhibitor 1 associates with progression of hepatocellular carcinoma.Q39034955
Expression of PIM-2 and NF-κB genes is increased in patients with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) and is associated with complete remission rate and overall survivalQ39141546
The serine/threonine kinase Pim-2 is a novel anti-apoptotic mediator in myeloma cellsQ39562043
Pim-2 activates API-5 to inhibit the apoptosis of hepatocellular carcinoma cells through NF-kappaB pathwayQ39788679
Isolation and characterization of a novel oncogene, amplified in liver cancer 1, within a commonly amplified region at 1q21 in hepatocellular carcinoma.Q40049355
Identification of a regulatory autophosphorylation site in the serine-threonine kinase RIP2.Q40258219
Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survivalQ41868647
PhosphoNetworks: a database for human phosphorylation networksQ42129105
Down-regulation of tyrosine aminotransferase at a frequently deleted region 16q22 contributes to the pathogenesis of hepatocellular carcinoma.Q43139836
Murine leukemia virus-induced T-cell lymphomagenesis: Integration of proviruses in a distinct chromosomal regionQ45796591
Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition by way of Akt/GSK-3β/Snail signaling.Q47821487
SPOCK1 is regulated by CHD1L and blocks apoptosis and promotes HCC cell invasiveness and metastasis in mice.Q53263915
Hepatocellular carcinomaQ73328021
Epidemiology of hepatocellular carcinomaQ73541726
P433issue7
P921main subjectNF-κBQ411114
hepatocellular carcinomaQ1148337
P304page(s)510
P577publication date2020-07-02
P1433published inCell Death and DiseaseQ2197222
P1476titlePIM2 promotes hepatocellular carcinoma tumorigenesis and progression through activating NF-κB signaling pathway
P478volume11