Assessment of Pharmacokinetic Interaction Between Letermovir and Fluconazole in Healthy Participants

scientific article published on 22 July 2020

Assessment of Pharmacokinetic Interaction Between Letermovir and Fluconazole in Healthy Participants is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/CPDD.852
P698PubMed publication ID32700459

P2093author name stringTian Zhao
Marian Iwamoto
Adedayo Adedoyin
S Aubrey Stoch
Deborah Panebianco
Jacqueline B McCrea
Charles Tomek
Craig Fancourt
Karsten Menzel
P2860cites workPharmacokinetics of antifungal agents in onychomycosesQ34320789
Fluconazole for the management of invasive candidiasis: where do we stand after 15 years?Q34490092
The novel anticytomegalovirus compound AIC246 (Letermovir) inhibits human cytomegalovirus replication through a specific antiviral mechanism that involves the viral terminaseQ38631773
Clinical pharmacokinetics of fluconazoleQ40884105
The pharmacokinetics of fluconazole in healthy Chinese adult volunteers: influence of ethnicity and genderQ43067618
Letermovir Prophylaxis for Cytomegalovirus in Hematopoietic-Cell Transplantation.Q45955430
Gender differences in the oral pharmacokinetics of fluconazoleQ46894977
Clinical pharmacokinetics of fluconazole in superficial and systemic mycosesQ48666983
Intravenous Hydroxypropyl β-Cyclodextrin Formulation of Letermovir: A Phase I, Randomized, Single-Ascending, and Multiple-Dose Trial.Q50546849
Pharmacokinetics and Safety of Letermovir Coadministered With Cyclosporine A or Tacrolimus in Healthy Subjects.Q53807644
Induction of fluconazole metabolism by rifampin: in vivo study in humans.Q54079254
Letermovir for the prevention of cytomegalovirus infection and disease in transplant recipients: an evidence-based review.Q64993136
Effect of repeated dosing on the pharmacokinetics of oral fluconazole in bone marrow transplant patientsQ74321682
Pharmacokinetics and Tolerability of Letermovir Coadministered With Azole Antifungals (Posaconazole or Voriconazole) in Healthy SubjectsQ88173355
PBPK Modeling Strategy for Predicting Complex Drug Interactions of Letermovir as a Perpetrator in Support of Product LabelingQ89100456
Pharmacogenetic Analysis of OATP1B1, UGT1A1, and BCRP Variants in Relation to the Pharmacokinetics of Letermovir in Previously Conducted Clinical StudiesQ91510806
Pharmacokinetics of Tacrolimus Coadministered With Letermovir in Allogeneic Hematopoietic Stem Cell Transplantation PatientsQ92165424
Pharmacokinetic Drug-Drug Interactions Between Letermovir and the Immunosuppressants Cyclosporine, Tacrolimus, Sirolimus, and Mycophenolate MofetilQ93128495
P921main subjectfluconazoleQ411478
P577publication date2020-07-22
P1433published inClinical pharmacology in drug developmentQ27726600
P1476titleAssessment of Pharmacokinetic Interaction Between Letermovir and Fluconazole in Healthy Participants