ALDH2 contributes to melatonin-induced protection against APP/PS1 mutation-prompted cardiac anomalies through cGAS-STING-TBK1-mediated regulation of mitophagy

scientific article published on 24 July 2020

ALDH2 contributes to melatonin-induced protection against APP/PS1 mutation-prompted cardiac anomalies through cGAS-STING-TBK1-mediated regulation of mitophagy is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/S41392-020-0171-5
P698PubMed publication ID32703954

P50authorJun RenQ87598500
P2093author name stringLin Wang
Russel J Reiter
Xiaoming Wang
Hao Zhou
Dongdong Sun
Shuyi Wang
Subat Turdi
Xing Qin
Bruce Culver
P2860cites workAlzheimer's disease: genes, proteins, and therapyQ28131806
Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patientsQ28200916
Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signalingQ28509444
Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneityQ28592098
Presenilin 1 is essential for cardiac morphogenesisQ28592290
Cardiomyocyte contractile dysfunction in the APPswe/PS1dE9 mouse model of Alzheimer's diseaseQ33473889
Mitochondrial aldehyde dehydrogenase and cardiac diseasesQ34113383
Ginsenoside compound K promotes β-amyloid peptide clearance in primary astrocytes via autophagy enhancementQ34120346
Targeting aldehyde dehydrogenase 2: new therapeutic opportunitiesQ34395219
Mutations of presenilin genes in dilated cardiomyopathy and heart failureQ35221755
Cofilin-2 phosphorylation and sequestration in myocardial aggregates: novel pathogenetic mechanisms for idiopathic dilated cardiomyopathyQ35232486
Characterization of Aldh2 (-/-) mice as an age-related model of cognitive impairment and Alzheimer's diseaseQ35537887
The human pineal gland and melatonin in aging and Alzheimer's diseaseQ36051556
Prophylactic melatonin significantly reduces Alzheimer's neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPP(swe)/PS1 miceQ36433222
Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolismQ37612521
Mitochondrial aldehyde dehydrogenase obliterates insulin resistance-induced cardiac dysfunction through deacetylation of PGC-1α.Q37718230
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewalQ37909890
STING-IRF3 Triggers Endothelial Inflammation in Response to Free Fatty Acid-Induced Mitochondrial Damage in Diet-Induced ObesityQ38711931
Membrane receptor-dependent Notch1/Hes1 activation by melatonin protects against myocardial ischemia-reperfusion injury: in vivo and in vitro studiesQ38840664
Complex inhibition of autophagy by mitochondrial aldehyde dehydrogenase shortens lifespan and exacerbates cardiac agingQ38873016
Cyclic GMP-AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA.Q39235226
Melatonin treatment restores mitochondrial function in Alzheimer's mice: a mitochondrial protective role of melatonin membrane receptor signalingQ39585259
Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activationQ39869345
Reduced hippocampal MT2 melatonin receptor expression in Alzheimer's disease.Q40477472
Mitochondrial aldehyde dehydrogenase 2 accentuates aging-induced cardiac remodeling and contractile dysfunction: role of AMPK, Sirt1, and mitochondrial functionQ41089202
A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease.Q41513615
Absence of association on aldehyde dehydrogenase 2 (ALDH2) polymorphism with Mongolian Alzheimer patientsQ43242106
Molecular changes underlying reduced pineal melatonin levels in Alzheimer disease: alterations in preclinical and clinical stagesQ44690290
Sasanquasaponin promotes cellular chloride efflux and elicits cardioprotection via the PKCε pathwayQ46583059
Mitochondrial aldehyde dehydrogenase polymorphism is not associated with incidence of Alzheimer's diseaseQ46775472
Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-K B/JNK signaling pathway in aging mouse modelQ46813751
Decreased proliferation of hippocampal progenitor cells in APPswe/PS1dE9 transgenic miceQ46843130
Aβ Amyloid Pathology Affects the Hearts of Patients With Alzheimer's Disease: Mind the HeartQ47094954
ULK1-regulated autophagy: A mechanism in cellular protection for ALDH2 against hyperglycemiaQ47413039
DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway.Q47583657
The preventive effects of edible folic acid on cardiomyocyte apoptosis and survival in early onset triple-transgenic Alzheimer's disease model miceQ47606537
Polymorphisms in the aldehyde dehydrogenase 2 and dopamine β hydroxylase genes are not associated with Alzheimer's diseaseQ48887400
Cytosolic DNA Sensing Promotes Macrophage Transformation and Governs Myocardial Ischemic InjuryQ50044861
Role of ADH1B rs1229984 and ALDH2 rs671 gene polymorphisms in the development of Alzheimer's disease.Q51347560
Meta-analysis of aldehyde dehydrogenase 2 gene polymorphism and Alzheimer's disease in East Asians.Q53318562
ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1α deacetylation.Q54982183
Aldehyde dehydrogenase 2 deficiency promotes atherosclerotic plaque instability through accelerating mitochondrial ROS-mediated vascular smooth muscle cell senescenceQ57477737
The Protective Effects of Clams on Hypercholesterolemia in Late-Stage Triple-Transgenic Alzheimer's Diseased Mice HeartsQ58805053
Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn careQ64066241
Association Between Polymorphisms and Risk of Alzheimer's Disease and Parkinson's Disease: A Meta-Analysis Based on 5,315 IndividualsQ64106927
STING directly activates autophagy to tune the innate immune responseQ64134225
Decreased level of melatonin in serum predicts left ventricular remodelling after acute myocardial infarctionQ84002871
The potential usefulness of serum melatonin level to predict heart failure in patients with hypertensive cardiomyopathyQ87758004
Inhibitory effect of melatonin on necroptosis via repressing the Ripk3-PGAM5-CypD-mPTP pathway attenuates cardiac microvascular ischemia-reperfusion injuryQ88706860
The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STINGQ90638631
Getting to the Heart of Alzheimer DiseaseQ90864060
Cardiac Abnormalities in Alzheimer Disease: Clinical Relevance Beyond Pathophysiological Rationale and Instrumental Findings?Q91295177
Plasma levels of melatonin in dilated cardiomyopathyQ91331069
Melatonin protective effect against amyloid β-induced neurotoxicity mediated by mitochondrial biogenesis; involvement of hippocampal Sirtuin-1 signaling pathwayQ91623906
STAT3 inhibition enhances CDN-induced STING signaling and antitumor immunityQ91801441
Pineal gland dysfunction in Alzheimer's disease: relationship with the immune-pineal axis, sleep disturbance, and neurogenesisQ91804786
Genetics and Epigenetics in Aging and Longevity: Myths and TruthsQ91866810
The cGAS-cGAMP-STING Pathway: A Molecular Link Between Immunity and MetabolismQ92169704
Autophagy induction via STING trafficking is a primordial function of the cGAS pathwayQ92179904
Aldehyde Dehydrogenase 2 (ALDH2) and Aging: Is There a Sensible Link?Q92330089
Interrelationship between Alzheimer's disease and cardiac dysfunction: the brain-heart continuum?Q92384769
Retinoic acid worsens ATG10-dependent autophagy impairment in TBK1-mutant hiPSC-derived motoneurons through SQSTM1/p62 accumulationQ92796037
Mitochondrial ALDH2 protects against lipopolysaccharide-induced myocardial contractile dysfunction by suppression of ER stress and autophagyQ92850463
Obesity-associated alterations in cardiac connexin-43 and PKC signaling are attenuated by melatonin and omega-3 fatty acids in female ratsQ93185457
P433issue1
P304page(s)119
P577publication date2020-07-24
P1433published inSignal Transduction and Targeted TherapyQ108821959
P1476titleALDH2 contributes to melatonin-induced protection against APP/PS1 mutation-prompted cardiac anomalies through cGAS-STING-TBK1-mediated regulation of mitophagy
P478volume5

Reverse relations

Q99201833Beclin1 Haploinsufficiency accentuates second-hand smoke exposure -induced myocardial Remodeling and contractile dysfunction through a STING-mediated mechanismcites workP2860

Search more.