A Network Pharmacology Approach to Investigate the Active Compounds and Mechanisms of Musk for Ischemic Stroke

scientific article published on 03 July 2020

A Network Pharmacology Approach to Investigate the Active Compounds and Mechanisms of Musk for Ischemic Stroke is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1155/2020/4063180
P932PMC publication ID7354650
P698PubMed publication ID32714405

P50authorChanglin ZhangQ97883944
Yuanqi ZhaoQ59683732
P2093author name stringYifan Sun
Lingling Liu
Hui Mao
Shaoqin Lin
Haoxuan Chen
Jiaying Lan
Yingdi Liao
P2860cites workAn automated method for finding molecular complexes in large protein interaction networksQ21284295
Gene ontology: tool for the unification of biologyQ23781406
Global brain inflammation in strokeQ91805720
Dual Effects of Chinese Herbal Medicines on Angiogenesis in Cancer and Ischemic Stroke Treatments: Role of HIF-1 NetworkQ91811051
Neuroprotective Effects of Musk of Muskrat on Transient Focal Cerebral Ischemia in RatsQ92155876
Systems Pharmacology for Investigation of the Mechanisms of Action of Traditional Chinese Medicine in Drug DiscoveryQ92403114
Stroke in China: advances and challenges in epidemiology, prevention, and managementQ92409091
Gene polymorphisms and circulating levels of the TNF-alpha are associated with ischemic stroke: A meta-analysis based on 19,873 individualsQ92903869
Mortality, morbidity, and risk factors in China and its provinces, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017Q93084985
Akt activation improves microregional oxygen supply/consumption balance after cerebral ischemia-reperfusion.Q47839332
Muscone exerts neuroprotection in an experimental model of stroke via inhibition of the fas pathway.Q48377076
Knockdown of Nrf2 inhibits angiogenesis by down-regulating VEGF expression through PI3K/Akt signaling pathway in cerebral microvascular endothelial cells under hypoxic conditionsQ48522321
AKT-related autophagy contributes to the neuroprotective efficacy of hydroxysafflor yellow A against ischemic stroke in ratsQ48788009
Protection against cerebral infarction by Withaferin A involves inhibition of neuronal apoptosis, activation of PI3K/Akt signaling pathway, and reduced intimal hyperplasia via inhibition of VSMC migration and matrix metalloproteinases.Q51102422
Combining drug and gene similarity measures for drug-target elucidation.Q51604037
Current practice and future directions in the diagnosis and acute treatment of ischaemic strokeQ57482501
Network pharmacologyQ57932497
Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016Q63681992
From single drug targets to synergistic network pharmacology in ischemic strokeQ64072607
Metascape provides a biologist-oriented resource for the analysis of systems-level datasetsQ64081579
Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain-barrier disruption after ischemic stroke.Q64889137
Salidroside alleviates ischemic brain injury in mice with ischemic stroke through regulating BDNK mediated PI3K/Akt pathwayQ90980692
STRING: known and predicted protein-protein associations, integrated and transferred across organismsQ24558597
DrugBank: a knowledgebase for drugs, drug actions and drug targetsQ24650300
Testosterone and the cardiovascular system: a comprehensive review of the basic science literatureQ26824556
Window of opportunity: estrogen as a treatment for ischemic strokeQ26828794
Studies of selective TNF inhibitors in the treatment of brain injury from stroke and trauma: a review of the evidence to dateQ27001147
DAVID: Database for Annotation, Visualization, and Integrated DiscoveryQ27499374
Characterization of the c-Jun N-terminal kinase-BimEL signaling pathway in neuronal apoptosis.Q27919665
The Kyoto Encyclopedia of Genes and Genomes—KEGGQ28109327
Enhanced platelet activation by prolactin in patients with ischemic strokeQ28198488
DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variantsQ28584435
The immunology of stroke: from mechanisms to translationQ29620066
Cerebral ischemia induces transcription of inflammatory and extracellular-matrix-related genes in rat cerebral arteriesQ33298079
Pathologies associated with the p53 responseQ33931980
17β-estradiol and inflammation: implications for ischemic strokeQ34237961
The human Tp53 Arg72Pro polymorphism explains different functional prognosis in stroke.Q34681421
The Human Phenotype Ontology: a tool for annotating and analyzing human hereditary diseaseQ34865360
Preclinical evaluation of recombinant T cell receptor ligand RTL1000 as a therapeutic agent in ischemic strokeQ34982895
The role of tumor necrosis factor-α and TNF-α receptors in cerebral arteries following cerebral ischemia in ratQ35225934
Akt as a mediator of cell deathQ36161549
Estrogens and experimental ischemic stroke: a systematic reviewQ36377761
Transcription factors in airway diseasesQ36545751
BATMAN-TCM: a Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese MedicineQ36583396
Delayed intramuscular human neurotrophin-3 improves recovery in adult and elderly rats after strokeQ36670885
High-dose estrogen treatment at reperfusion reduces lesion volume and accelerates recovery of sensorimotor function after experimental ischemic stroke.Q36931700
T- and B-cell-deficient mice with experimental stroke have reduced lesion size and inflammationQ36992998
PIKKing on PKB: regulation of PKB activity by phosphorylationQ37419888
Involvement of p38 MAPK in reactive astrogliosis induced by ischemic stroke.Q37704935
Current perspective of pathophysiological and interventional effects on endothelial progenitor cell biology: focus on PI3K/AKT/eNOS pathway.Q37742844
Epidemiology and the global burden of strokeQ37969821
Characteristics of traditional Chinese medicine usage in patients with stroke in Taiwan: A nationwide population-based study.Q38879628
Evidence that neuronal Notch-1 promotes JNK/c-Jun activation and cell death following ischemic stress.Q38962027
Sex Hormones and Ischemic Stroke: A Prospective Cohort Study and Meta-AnalysesQ41175854
PRL as a novel potent cofactor for platelet aggregationQ43819865
A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemiaQ44560865
Traditional Chinese medicine and sports drug testing: identification of natural steroid administration in doping control urine samples resulting from musk (pod) extractsQ44591484
Therapeutic target database update 2018: enriched resource for facilitating bench-to-clinic research of targeted therapeuticsQ47116549
Searching Online Mendelian Inheritance in Man (OMIM): A Knowledgebase of Human Genes and Genetic PhenotypesQ47786222
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesCytoscapeQ3699942
P304page(s)4063180
P577publication date2020-07-03
P1433published inEvidence-based Complementary and Alternative MedicineQ5418319
P1476titleA Network Pharmacology Approach to Investigate the Active Compounds and Mechanisms of Musk for Ischemic Stroke
P478volume2020

Search more.