Rhein Suppresses Neuroinflammation via Multiple Signaling Pathways in LPS-Stimulated BV2 Microglia Cells

scientific article published on 29 June 2020

Rhein Suppresses Neuroinflammation via Multiple Signaling Pathways in LPS-Stimulated BV2 Microglia Cells is …
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scholarly articleQ13442814

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P356DOI10.1155/2020/7210627
P932PMC publication ID7341424
P698PubMed publication ID32714414

P50authorJie-Kun LuoQ88507866
Tao TangQ89449776
Piao ZhengQ89767679
Yang WangQ90118771
P2093author name stringJing Zhou
Wei Zhang
Jun Zheng
Xuefei Tian
Hanjin Cui
Zhaoyu Yang
P2860cites workDifferential effects of interleukin-1beta on neurotoxicity, cytokine induction and glial reaction in specific brain regions.Q54647613
Transplantation of mesenchymal stem cells genetically engineered to overexpress interleukin-10 promotes alternative inflammatory response in rat model of traumatic brain injuryQ60920490
A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injuryQ64055705
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Tumor necrosis factor alpha: a link between neuroinflammation and excitotoxicityQ21284512
Evolutionary development of embryonic cerebrospinal fluid composition and regulation: an open research field with implications for brain development and functionQ26765398
A Comprehensive and System Review for the Pharmacological Mechanism of Action of Rhein, an Active Anthraquinone IngredientQ27023870
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Interactions of inflammatory mediators stimulating release of calcitonin gene-related peptide, substance P and prostaglandin E(2) from isolated rat skinQ31882950
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Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12Q34145393
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Astrocyte response to IFN-γ limits IL-6-mediated microglia activation and progressive autoimmune encephalomyelitisQ35540927
Rhein prevents endotoxin-induced acute kidney injury by inhibiting NF-κB activitiesQ35824667
The p38 MAP Kinase Family as Regulators of Proinflammatory Cytokine Production in Degenerative Diseases of the CNS.Q36040645
Postinjury treatment with rolipram increases hemorrhage after traumatic brain injuryQ36162694
GM-CSF increases LPS-induced production of proinflammatory mediators via upregulation of TLR4 and CD14 in murine microgliaQ36591794
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Rhein and rhubarb similarly protect the blood-brain barrier after experimental traumatic brain injury via gp91phox subunit of NADPH oxidase/ROS/ERK/MMP-9 signaling pathwayQ37453818
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Suppression of Lipopolysaccharide-Induced Neuroinflammation by Morin via MAPK, PI3K/Akt, and PKA/HO-1 Signaling Pathway Modulation.Q38407191
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LRRK2 in peripheral and central nervous system innate immunity: its link to Parkinson's disease.Q39137339
Hypoxia-induced iNOS expression in microglia is regulated by the PI3-kinase/Akt/mTOR signaling pathway and activation of hypoxia inducible factor-1alphaQ40241940
Minocycline affects microglia activation, Abeta deposition, and behavior in APP-tg miceQ40305380
Neuropathological sequelae of traumatic brain injury: relationship to neurochemical and biomechanical mechanismsQ41089582
An ultra high performance liquid chromatography with tandem mass spectrometry method for plasma and cerebrospinal fluid pharmacokinetics of rhein in patients with traumatic brain injury after administration of rhubarb decoctionQ41566211
Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain.Q43489000
Rhein inhibits interleukin-1 beta-induced activation of MEK/ERK pathway and DNA binding of NF-kappa B and AP-1 in chondrocytes cultured in hypoxia: a potential mechanism for its disease-modifying effect in osteoarthritisQ44607171
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectmicrogliaQ1622829
P304page(s)7210627
P577publication date2020-06-29
P1433published inEvidence-based Complementary and Alternative MedicineQ5418319
P1476titleRhein Suppresses Neuroinflammation via Multiple Signaling Pathways in LPS-Stimulated BV2 Microglia Cells
P478volume2020