The artemisinin analog SM934 alleviates dry eye disease in rodent models by regulating TLR4/NF-κB/NLRP3 signaling

scientific article published on 03 August 2020

The artemisinin analog SM934 alleviates dry eye disease in rodent models by regulating TLR4/NF-κB/NLRP3 signaling is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/S41401-020-0484-5
P932PMC publication ID8114933
P698PubMed publication ID32747720

P2093author name stringWei Tang
Qian Li
Yu-Ting Liu
Di Fan
Jian-Ping Zuo
Ze-Min Lin
Xiao-Qian Yang
Shi-Qi Cao
Feng-Hua Zhu
Shi-Jun He
Mei-Juan Shao
Fang-Ming Yang
P2860cites workThe definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007)Q80347907
TLR4 contributes to disease-inducing mechanisms resulting in central nervous system autoimmune diseaseQ81040935
Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influencesQ81880357
Alcaftadine 0.25% versus Olopatadine 0.1% in Preventing Cedar Pollen Allergic Conjunctivitis in Japan: A Randomized StudyQ88067409
Artemisinin analogue SM934 ameliorates DSS-induced mouse ulcerative colitis via suppressing neutrophils and macrophagesQ88924937
Kinetics of Corneal Antigen Presenting Cells in Experimental Dry Eye DiseaseQ89928664
Ocular mucins in dry eye diseaseQ92040385
Corrigendum to "TFOS DEWS II pathophysiology report" [Ocul. Surf. 15 (3) (2017) 438-510]Q92545653
The ocular surface epithelial barrier and other mechanisms of mucosal protection: from allergy to infectious diseasesQ26865809
The Eye Drop Preservative Benzalkonium Chloride Potently Induces Mitochondrial Dysfunction and Preferentially Affects LHON Mutant CellsQ30353026
New tools for the evaluation of toxic ocular surface changes in the rat.Q33308447
Changes in corneal epithelial layer inflammatory cells in aqueous tear-deficient dry eye.Q33486416
SM934 treated lupus-prone NZB × NZW F1 mice by enhancing macrophage interleukin-10 production and suppressing pathogenic T cell developmentQ34184574
Dry Eye Disease: Impact on Quality of Life and VisionQ34346990
Topical omega-3 and omega-6 fatty acids for treatment of dry eye.Q34749224
Artemisinin analogue SM934 ameliorates murine experimental autoimmune encephalomyelitis through enhancing the expansion and functions of regulatory T cellQ34979858
Artemisinin analogue SM934 ameliorates the proteinuria and renal fibrosis in rat experimental membranous nephropathyQ35080166
Innate immune recognition of cancerQ35549322
α-Melanocyte-stimulating hormone ameliorates ocular surface dysfunctions and lesions in a scopolamine-induced dry eye model via PKA-CREB and MEK-Erk pathwaysQ36388893
Effect of desiccating environmental stress versus systemic muscarinic AChR blockade on dry eye immunopathogenesisQ36758312
Therapeutic effects of the artemisinin analog SM934 on lupus-prone MRL/lpr mice via inhibition of TLR-triggered B-cell activation and plasma cell formationQ36870048
Inflammatory Response to Lipopolysaccharide on the Ocular Surface in a Murine Dry Eye Model.Q36872927
Dry eye disease: an immune-mediated ocular surface disorderQ36916372
Expression of toll-like receptor 4 contributes to corneal inflammation in experimental dry eye diseaseQ37013881
Benzalkonium chloride and glaucomaQ37710684
A Comparison of the Effects of Benzalkonium Chloride on Ocular Surfaces between C57BL/6 and BALB/c Mice.Q37729041
Therapeutic targeting of innate immunity with Toll-like receptor 4 (TLR4) antagonistsQ37888136
TFOS DEWS II Tear Film Report.Q38652990
TFOS DEWS II Epidemiology ReportQ38652994
TFOS DEWS II Definition and Classification Report.Q38665717
Ocular inflammation and corneal permeability alteration by benzalkonium chloride in rats: a protective effect of a myosin light chain kinase inhibitorQ39990324
Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surfaceQ45158772
Synthesis and immunosuppressive activity of new artemisinin derivatives. 1. [12(beta or alpha)-Dihydroartemisininoxy]phen(ox)yl aliphatic acids and estersQ46586123
Protective effects of carbenoxolone, an 11β-HSD1 inhibitor, against chemical induced dry eye syndrome.Q50193141
Desiccating stress stimulates expression of matrix metalloproteinases by the corneal epithelium.Q50721017
Oral administration of artemisinin analog SM934 ameliorates lupus syndromes in MRL/lpr mice by inhibiting Th1 and Th17 cell responses.Q51477256
Downregulation of the NLRP3 inflammasome by adiponectin rescues Duchenne muscular dystrophy.Q51737740
Chemokine receptor CCR5 expression in conjunctival epithelium of patients with dry eye syndrome.Q54602794
High-Mobility Group Box 1 in Dry Eye Inflammation.Q55010929
MyD88 Deficiency Protects Against Dry Eye–Induced Damage.Q55355486
Inhibition of Toll-like receptor 4 with eritoran attenuates myocardial ischemia-reperfusion injuryQ79839081
Synthesis and immunosuppressive activity of new artemisinin derivatives. Part 2: 2-[12(beta or alpha)-dihydroartemisinoxymethyl(or 1'-ethyl)]phenoxyl propionic acids and estersQ80110208
P4510describes a project that usesImageJQ1659584
P921main subjectNF-κBQ411114
eye diseaseQ3041498
P577publication date2020-08-03
P1433published inActa Pharmacologica SinicaQ15749885
P1476titleThe artemisinin analog SM934 alleviates dry eye disease in rodent models by regulating TLR4/NF-κB/NLRP3 signaling

Search more.