Targeted therapy for hepatocellular carcinoma

scientific article published on 11 August 2020

Targeted therapy for hepatocellular carcinoma is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41392-020-00264-X
P698PubMed publication ID32782275

P2093author name stringJian Zhou
Xin-Rong Yang
Ashley R Dennison
Ao Huang
Wen-Yuan Chung
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Increased FGF19 copy number is frequently detected in hepatocellular carcinoma with a complete response after sorafenib treatment.Q37580172
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Clonal Heterogeneity and Tumor Evolution: Past, Present, and the FutureQ38758819
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Human and mouse VEGFA-amplified hepatocellular carcinomas are highly sensitive to sorafenib treatment.Q39009644
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Rheumatic and musculoskeletal immune-related adverse events due to immune checkpoint inhibitors: A systematic review of the literatureQ39044741
Expression of SLC22A1 variants may affect the response of hepatocellular carcinoma and cholangiocarcinoma to sorafenib.Q39175179
αB-crystallin complexes with 14-3-3ζ to induce epithelial-mesenchymal transition and resistance to sorafenib in hepatocellular carcinomaQ39211222
FGF3/FGF4 amplification and multiple lung metastases in responders to sorafenib in hepatocellular carcinomaQ39297937
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Sorafenib after resection improves the outcome of BCLC stage C hepatocellular carcinomaQ39929763
Regional differences in sorafenib-treated patients with hepatocellular carcinoma: GIDEON observational studyQ39979280
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Adjuvant sorafenib for hepatocellular carcinoma after resection or ablation (STORM): a phase 3, randomised, double-blind, placebo-controlled trialQ40548309
Concurrent sorafenib therapy extends the interval to subsequent TACE for patients with unresectable hepatocellular carcinomaQ40846805
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Effects of sorafenib combined with low-dose interferon therapy for advanced hepatocellular carcinoma: a pilot studyQ41024086
Safety and Pharmacokinetics of Lenvatinib in Patients with Advanced Hepatocellular CarcinomaQ41187204
Adjuvant sorafenib reduced mortality and prolonged overall survival and post-recurrence survival in hepatocellular carcinoma patients after curative resection: a single-center experienceQ41496721
Intratumor heterogeneity in hepatocellular carcinomaQ42186312
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Single cell analysis reveals cancer stem cell heterogeneity in hepatocellular carcinoma.Q48282479
A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity.Q48574942
Combined effects of PLK1 and RAS in hepatocellular carcinoma reveal rigosertib as promising novel therapeutic "dual-hit" optionQ49402953
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Characteristics of patients with sorafenib-treated advanced hepatocellular carcinoma eligible for second-line treatmentQ50169188
Circumventing intratumoral heterogeneity to identify potential therapeutic targets in hepatocellular carcinoma.Q50671717
Sorafenib treatment is save and may affect survival of recurrent hepatocellular carcinoma after liver transplantation.Q50767199
A pilot study of ultra-deep targeted sequencing of plasma DNA identifies driver mutations in hepatocellular carcinoma.Q52599927
Analysis of Tissue and Circulating Tumor DNA by Next-Generation Sequencing of Hepatocellular Carcinoma: Implications for Targeted Therapeutics.Q52684456
Genetic profiling using plasma-derived cell-free DNA in therapy-naïve hepatocellular carcinoma patients: a pilot study.Q52728559
Trunk mutational events present minimal intra- and inter-tumoral heterogeneity in hepatocellular carcinoma.Q52757804
Cyclin E1 Inhibition can Overcome Sorafenib Resistance in Hepatocellular Carcinoma Cells Through Mcl-1 Suppression.Q52900635
Sorafenib in combination with transarterial chemoembolization improves the survival of patients with unresectable hepatocellular carcinoma: a propensity score matching study.Q53112763
Comparison of hepatic arterial infusion chemotherapy versus sorafenib monotherapy in patients with advanced hepatocellular carcinoma.Q53449774
Patient-derived organoids model treatment response of metastatic gastrointestinal cancers.Q53707065
Application of Sequencing, Liquid Biopsies, and Patient-Derived Xenografts for Personalized Medicine in Melanoma.Q53803543
Effect and safety of sorafenib in patients with intermediate hepatocellular carcinoma who received transarterial chemoembolization: A retrospective comparative study.Q53818396
A Randomized Phase II Open-Label Multi-Institution Study of the Combination of Bevacizumab and Erlotinib Compared to Sorafenib in the First-Line Treatment of Patients with Advanced Hepatocellular Carcinoma.Q53826807
Efficacy and Safety of Transarterial Chemoembolization Plus External Beam Radiotherapy vs Sorafenib in Hepatocellular Carcinoma With Macroscopic Vascular Invasion: A Randomized Clinical Trial.Q53837211
Cabozantinib suppresses tumor growth and metastasis in hepatocellular carcinoma by a dual blockade of VEGFR2 and MET.Q54362470
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Cabozantinib in Patients with Advanced and Progressing Hepatocellular CarcinomaQ56373211
Phase III study of sorafenib after transarterial chemoembolisation in Japanese and Korean patients with unresectable hepatocellular carcinomaQ57214428
Guidelines for Diagnosis and Treatment of Primary Liver Cancer in China (2017 Edition)Q57494813
Relationship between baseline hepatic status and outcome, and effect of sorafenib on liver function: SHARP trial subanalysesQ57756652
Anti-PD-1 Antibody SHR-1210 combined with Apatinib for Advanced Hepatocellular Carcinoma, Gastric or Esophagogastric Junction Cancer: An Open-label, Dose Escalation and Expansion StudyQ57801964
Molecular predictors of prevention of recurrence in HCC with sorafenib as adjuvant treatment and prognostic factors in the phase 3 STORM trialQ58020775
Using ALBI score at the start of sorafenib treatment to predict regorafenib treatment candidates in patients with hepatocellular carcinomaQ58089680
Destructive Thyroiditis Induced by Lenvatinib in Three Patients with Hepatocellular CarcinomaQ58544320
Regorafenib treatment for patients with hepatocellular carcinoma who progressed on sorafenib-A cost-effectiveness analysisQ58588183
Efficacy of annexin A3 blockade in sensitizing hepatocellular carcinoma to sorafenib and regorafenibQ59185719
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Sorafenib plus tegafur-uracil (UFT) versus sorafenib as first line systemic treatment for patients with advanced stage HCC: a Phase II trial (ESLC01 study)Q59795984
Immunomodulatory activity of lenvatinib contributes to antitumor activity in the Hepa1-6 hepatocellular carcinoma modelQ59797774
The multikinase inhibitor regorafenib decreases angiogenesis and improves portal hypertensionQ59799447
Safety of Liver Resection for Hepatocellular Carcinoma After Sorafenib Therapy: A Multicenter Case-Matched StudyQ60641631
Should we apply sorafenib in hepatocellular carcinoma patients with microvascular invasion after curative hepatectomy?Q60912071
Combination Therapy after TACE for Hepatocellular Carcinoma with Macroscopic Vascular Invasion: Stereotactic Body Radiotherapy versus SorafenibQ60954607
Stereotactic Body Radiation Therapy as an Alternative Treatment for Patients with Hepatocellular Carcinoma Compared to Sorafenib: A Propensity Score AnalysisQ61054484
Clinical features of lenvatinib for unresectable hepatocellular carcinoma in real-world conditions: Multicenter analysisQ61455444
Prolonged tumor response associated with sequential immune checkpoint inhibitor combination treatment and regorafenib in a patient with advanced pretreated hepatocellular carcinomaQ64094384
Transarterial Chemoembolization (TACE) Combined with Sorafenib TACE Alone for Unresectable Hepatocellular Carcinoma: A Propensity Score Matching StudyQ64237893
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Cost-effectiveness analysis of lenvatinib treatment for patients with unresectable hepatocellular carcinoma (uHCC) compared with sorafenib in Japan.Q64930871
The Efficacy and Safety of Apatinib Treatment for Patients with Unresectable or Relapsed Liver Cancer: a retrospective study.Q64962531
Medium or Large Hepatocellular Carcinoma: Sorafenib Combined with Transarterial Chemoembolization and Radiofrequency Ablation.Q64985970
Bevacizumab and erlotinib in previously untreated inoperable and metastatic hepatocellular carcinomaQ84240690
NCI-MATCH launch highlights new trial design in precision-medicine eraQ85528297
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Efficacy of sorafenib as adjuvant therapy to prevent early recurrence of hepatocellular carcinoma after curative surgery: A pilot studyQ86786798
Nuclear factor kappa B-mediated CD47 up-regulation promotes sorafenib resistance and its blockade synergizes the effect of sorafenib in hepatocellular carcinoma in miceQ87167977
VEGF and VEGFR genotyping in the prediction of clinical outcome for HCC patients receiving sorafenib: the ALICE-1 studyQ87259569
Next-Generation Sequencing of Circulating Tumor DNA Reveals Frequent Alterations in Advanced Hepatocellular CarcinomaQ87900984
Landscape of immune microenvironment in hepatocellular carcinoma and its additional impact on histological and molecular classificationQ88230772
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Clinical outcomes of sorafenib treatment failure for advanced hepatocellular carcinoma and candidates for regorafenib treatment in real-world practiceQ88437733
Prognostic Factors Associated with Postprogression Survival in Advanced Hepatocellular Carcinoma Patients Treated with Sorafenib Not Eligible for Second-Line Regorafenib TreatmentQ88558587
The Landscape of Actionable Genomic Alterations in Cell-Free Circulating Tumor DNA from 21,807 Advanced Cancer PatientsQ88732152
Analysis of the liver functional reserve of patients with advanced hepatocellular carcinoma undergoing sorafenib treatment: Prospects for regorafenib therapyQ88914229
Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib (KEYNOTE-224): a non-randomised, open-label phase 2 trialQ89012806
Circulating Tumor DNA Assays in Clinical Cancer ResearchQ89183577
Effects of liver-targeted drugs on expression of immune-related proteins in hepatocellular carcinoma cellsQ89235521
Camrelizumab in patients with previously treated advanced hepatocellular carcinoma: a multicentre, open-label, parallel-group, randomised, phase 2 trialQ89951585
Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancersQ90003849
Impact of Relative Dose Intensity of Early-phase Lenvatinib Treatment on Therapeutic Response in Hepatocellular CarcinomaQ90099671
CDK12 inhibition mediates DNA damage and is synergistic with sorafenib treatment in hepatocellular carcinomaQ90099879
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Targeting Jak/Stat pathway as a therapeutic strategy against SP/CD44+ tumorigenic cells in Akt/β-catenin-driven hepatocellular carcinomaQ90199717
Cost-effectiveness analysis of cabozantinib as second-line therapy in advanced hepatocellular carcinomaQ90208678
Multicenter retrospective analysis of the safety and efficacy of regorafenib after progression on sorafenib in Korean patients with hepatocellular carcinomaQ90318939
Genomic and Epigenomic Features of Primary and Recurrent Hepatocellular CarcinomasQ90330876
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Randomized, phase II trial of sequential hepatic arterial infusion chemotherapy and sorafenib versus sorafenib alone as initial therapy for advanced hepatocellular carcinoma: SCOOP-2 trialQ90727327
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Emerging agents and regimens for hepatocellular carcinomaQ90958064
Safety and Efficacy of Transcatheter Arterial Chemoembolization Plus Radiotherapy Combined With Sorafenib in Hepatocellular Carcinoma Showing Macrovascular InvasionQ91083985
Lenvatinib combined nivolumab injection followed by extended right hepatectomy is a feasible treatment for patients with massive hepatocellular carcinoma: a case reportQ91111514
Ramucirumab after sorafenib in patients with advanced hepatocellular carcinoma and increased α-fetoprotein concentrations (REACH-2): a randomised, double-blind, placebo-controlled, phase 3 trialQ91147767
Response to Lenvatinib Is Associated with Optimal RelativeDose Intensity in Hepatocellular Carcinoma: Experience in Clinical SettingsQ91253554
Clonal evolution in long-term follow-up patients with hepatocellular carcinomaQ91294508
MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1Q91317607
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Impact of Baseline Characteristics on the Overall Survival of HCC Patients Treated with Sorafenib: Ten Years of ExperienceQ91454010
Clinical characteristics and outcomes of candidates for second-line therapy, including regorafenib and ramucirumab, for advanced hepatocellular carcinoma after sorafenib treatmentQ91593715
Pembrolizumab As Second-Line Therapy in Patients With Advanced Hepatocellular Carcinoma in KEYNOTE-240: A Randomized, Double-Blind, Phase III TrialQ91603429
Tumour evolution in hepatocellular carcinomaQ91621531
Randomised, multicentre prospective trial of transarterial chemoembolisation (TACE) plus sorafenib as compared with TACE alone in patients with hepatocellular carcinoma: TACTICS trialQ91697434
Impact of Baseline ALBI Grade on the Outcomes of Hepatocellular Carcinoma Patients Treated with Lenvatinib: A Multicenter StudyQ91716418
Molecular portrait of high alpha-fetoprotein in hepatocellular carcinoma: implications for biomarker-driven clinical trialsQ91723916
Analysis of Liver Cancer Cell Lines Identifies Agents With Likely Efficacy Against Hepatocellular Carcinoma and Markers of ResponseQ91824075
Sorafenib Plus Hepatic Arterial Infusion of Oxaliplatin, Fluorouracil, and Leucovorin vs Sorafenib Alone for Hepatocellular Carcinoma With Portal Vein Invasion: A Randomized Clinical TrialQ91879742
Important Clinical Factors in Sequential Therapy Including Lenvatinib against Unresectable Hepatocellular CarcinomaQ91891911
Establishment of a hepatocellular carcinoma patient-derived xenograft platform and its application in biomarker identificationQ91917989
Excellent Response to Anti-PD-1 Therapy in a Patient with Hepatocellular Carcinoma Intolerant to SorafenibQ91942671
Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinomaQ91987072
Inhibition of cyclin E1 sensitizes hepatocellular carcinoma cells to regorafenib by mcl-1 suppressionQ92211224
Preliminary experience on safety of regorafenib after sorafenib failure in recurrent hepatocellular carcinoma after liver transplantationQ92309511
Lenvatinib as an Initial Treatment in Patients with Intermediate-Stage Hepatocellular Carcinoma Beyond Up-To-Seven Criteria and Child-Pugh A Liver Function: A Proof-Of-Concept StudyQ92343733
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Postoperative adjuvant sorafenib improves survival outcomes in hepatocellular carcinoma patients with microvascular invasion after R0 liver resection: a propensity score matching analysisQ92462883
Nivolumab in advanced hepatocellular carcinoma: Sorafenib-experienced Asian cohort analysisQ92605149
Genomic and transcriptional heterogeneity of multifocal hepatocellular carcinomaQ92646888
Impact of combined selective internal radiation therapy and sorafenib on survival in advanced hepatocellular carcinomaQ92671554
Cost-Effectiveness of Cabozantinib in the Second-Line Treatment of Advanced Hepatocellular CarcinomaQ92754898
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Hepatocellular CarcinomaQ93002915
P433issue1
P304page(s)146
P577publication date2020-08-11
P1433published inSignal Transduction and Targeted TherapyQ108821959
P1476titleTargeted therapy for hepatocellular carcinoma
P478volume5

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