Myeloid Cells as Clinical Biomarkers for Immune Checkpoint Blockade

scientific article published on 24 July 2020

Myeloid Cells as Clinical Biomarkers for Immune Checkpoint Blockade is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3389/FIMMU.2020.01590
P932PMC publication ID7393010
P698PubMed publication ID32793228

P2093author name stringIlaria Marigo
Elisa Peranzoni
Elena Masetto
Laura Pinton
Vincenzo Ingangi
P2860cites workThe Remarkable Plasticity of Macrophages: A Chance to Fight CancerQ92239433
Characterization of Myeloid-derived Suppressor Cells in a Patient With Lung Adenocarcinoma Undergoing Durvalumab Treatment: A Case ReportQ92252911
Immuno-PET identifies the myeloid compartment as a key contributor to the outcome of the antitumor response under PD-1 blockadeQ92376813
Correlative Analyses of the SARC028 Trial Reveal an Association Between Sarcoma-Associated Immune Infiltrate and Response to PembrolizumabQ92405933
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Stromal PD-1+ tumor-associated macrophages predict poor prognosis in lung adenocarcinomaQ92570413
B cells and tertiary lymphoid structures promote immunotherapy responseQ92669559
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Immune gene signatures for predicting durable clinical benefit of anti-PD-1 immunotherapy in patients with non-small cell lung cancerQ92782506
The Intersection between Tumor Angiogenesis and Immune SuppressionQ92827545
The Endless Saga of Monocyte DiversityQ92857692
Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanismsQ92883114
Epacadostat plus pembrolizumab versus placebo plus pembrolizumab in patients with unresectable or metastatic melanoma (ECHO-301/KEYNOTE-252): a phase 3, randomised, double-blind studyQ92915460
Liquid biopsy in the era of immuno-oncology: is it ready for prime-time use for cancer patients?Q92951596
Tumor-associated Macrophages as Prognostic and Predictive Biomarkers for Postoperative Adjuvant Chemotherapy in Patients with Stage II Colon CancerQ93109975
Gr-MDSC-linked asset as a potential immune biomarker in pretreated NSCLC receiving nivolumab as second-line therapyQ93119167
Nivolumab versus Everolimus in Advanced Renal-Cell CarcinomaQ41316099
Safety, activity, and immune correlates of anti-PD-1 antibody in cancerQ24633070
Recommendations for myeloid-derived suppressor cell nomenclature and characterization standardsQ26744395
Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapyQ27690653
The blockade of immune checkpoints in cancer immunotherapyQ27860852
Immune checkpoint blockade: a common denominator approach to cancer therapyQ28083981
Myeloid-derived suppressor cells as regulators of the immune systemQ28131637
Inhibition of T cell proliferation by macrophage tryptophan catabolismQ28142922
Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenaseQ28204166
Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8{alpha}+ dendritic cellsQ28248489
Type I interferon is selectively required by dendritic cells for immune rejection of tumorsQ28248500
The IDO1 selective inhibitor epacadostat enhances dendritic cell immunogenicity and lytic ability of tumor antigen-specific T cellsQ28275608
Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemiaQ28291815
Coordinated regulation of myeloid cells by tumoursQ28395157
MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancerQ29617772
PD-1 blockade induces responses by inhibiting adaptive immune resistanceQ29620856
PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphomaQ29620878
Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung CancerQ29620913
Ipilimumab treatment decreases monocytic MDSCs and increases CD8 effector memory T cells in long-term survivors with advanced melanomaQ33591598
CSF-1 receptor signaling in myeloid cellsQ33653719
Retracted: Macrophage Colony-Stimulating Factor Augments Tie2-Expressing Monocyte Differentiation, Angiogenic Function, and Recruitment in a Mouse Model of Breast CancerQ33707131
DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarizationQ33773787
PI3Kγ is a molecular switch that controls immune suppressionQ33822173
The fate and lifespan of human monocyte subsets in steady state and systemic inflammationQ33886544
Myeloid Cells and Related Chronic Inflammatory Factors as Novel Predictive Markers in Melanoma Treatment with IpilimumabQ41469907
Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint BlockadeQ41596176
VEGF Neutralization Plus CTLA-4 Blockade Alters Soluble and Cellular Factors Associated with Enhancing Lymphocyte Infiltration and Humoral Recognition in MelanomaQ41636554
Persistent induction of nitric oxide synthase in tumours from mice treated with the anti-tumour agent 5,6-dimethylxanthenone-4-acetic acidQ41809337
Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells.Q41974388
Immunomodulation of the tumor microenvironment by neutralization of Semaphorin 4D.Q42032661
The effect of anti-VEGF therapy on immature myeloid cell and dendritic cells in cancer patients.Q42080528
Neutrophil lymphocyte ratio and duration of prior anti-angiogenic therapy as biomarkers in metastatic RCC receiving immune checkpoint inhibitor therapy.Q42682360
Clinical implication of tumor-associated and immunological parameters in melanoma patients treated with ipilimumab.Q42968783
Trabectedin plus pegylated liposomal Doxorubicin in recurrent ovarian cancer.Q43048172
Selective inhibition of IDO1 effectively regulates mediators of antitumor immunityQ43144666
Frequencies of circulating MDSC correlate with clinical outcome of melanoma patients treated with ipilimumabQ44017442
Randomized phase III placebo-controlled trial of carboplatin and paclitaxel with or without the vascular disrupting agent vadimezan (ASA404) in advanced non-small-cell lung cancerQ44915586
Tumor and Microenvironment Evolution during Immunotherapy with NivolumabQ45070125
Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer.Q45866300
The STING agonist DMXAA triggers a cooperation between T lymphocytes and myeloid cells that leads to tumor regression.Q46142906
Post-treatment neutrophil-to-lymphocyte ratio at week 6 is prognostic in patients with advanced non-small cell lung cancers treated with anti-PD-1 antibodyQ47331134
Peripheral Blood Biomarkers Associated with Clinical Outcome in Non-Small Cell Lung Cancer Patients Treated with NivolumabQ47369863
Pretreatment neutrophil-to-lymphocyte ratio as a marker of outcomes in nivolumab-treated patients with advanced non-small-cell lung cancerQ47419988
The time-series behavior of neutrophil-to-lymphocyte ratio is useful as a predictive marker in non-small cell lung cancer.Q49979440
Neutrophil-to-lymphocyte ratio as an early marker of outcomes in patients with advanced non-small-cell lung cancer treated with nivolumabQ50016409
Axitinib in combination with pembrolizumab in patients with advanced renal cell cancer: a non-randomised, open-label, dose-finding, and dose-expansion phase 1b trial.Q50030031
Blood Predictive Biomarkers for Nivolumab in Advanced MelanomaQ50074098
Association Between Pretreatment Neutrophil-to-Lymphocyte Ratio and Outcome of Patients With Metastatic Renal-Cell Carcinoma Treated With NivolumabQ50198682
Angiopoietin-2 as a Biomarker and Target for Immune Checkpoint TherapyQ50216662
Local Activation of p53 in the Tumor Microenvironment Overcomes Immune Suppression and Enhances Antitumor Immunity.Q50676824
Combined Anti-VEGF and Anti-CTLA-4 Therapy Elicits Humoral Immunity to Galectin-1 Which Is Associated with Favorable Clinical Outcomes.Q51019599
Neoadjuvant PD-1 Blockade in Resectable Lung Cancer.Q52586562
T cell-induced CSF1 promotes melanoma resistance to PD1 blockade.Q52593234
Dynamic Changes in PD-L1 Expression and Immune Infiltrates Early During Treatment Predict Response to PD-1 Blockade in Melanoma.Q52681406
Association of Inflammatory Markers with Disease Progression in Patients with Metastatic Melanoma Treated with Immune Checkpoint Inhibitors.Q52721746
Neutrophil-to-Lymphocyte ratio (NLR) and Platelet-to-Lymphocyte ratio (PLR) as prognostic markers in patients with non-small cell lung cancer (NSCLC) treated with nivolumab.Q52758014
Eosinophils orchestrate cancer rejection by normalizing tumor vessels and enhancing infiltration of CD8(+) T cells.Q52948211
Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti-PD-1 treatment.Q53697047
Clinical Significance of Circulating CD33+CD11b+HLA-DR- Myeloid Cells in Patients with Stage IV Melanoma Treated with Ipilimumab.Q54706557
Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression.Q54940437
Myeloid cells obtained from the blood but not from the tumor can suppress T-cell proliferation in patients with melanoma.Q55056515
Anti-CTLA-4 based therapy elicits humoral immunity to galectin-3 in patients with metastatic melanoma.Q55119445
Myeloid-Derived Suppressor Cells Hinder the Anti-Cancer Activity of Immune Checkpoint Inhibitors.Q55295587
Anti-PD-1 therapy redirects macrophages from an M2 to an M1 phenotype inducing regression of OS lung metastases.Q55323964
The binding of an anti-PD-1 antibody to FcγRΙ has a profound impact on its biological functions.Q55417775
Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.Q55421471
Long term impact of CTLA4 blockade immunotherapy on regulatory and effector immune responses in patients with melanoma.Q55619003
Author Correction: High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapyQ56879989
Tumor-derived microRNAs induce myeloid suppressor cells and predict immunotherapy resistance in melanomaQ56886545
Signatures of T cell dysfunction and exclusion predict cancer immunotherapy responseQ56890003
An immune-active tumor microenvironment favors clinical response to ipilimumabQ56898024
Role of Macrophage Targeting in the Antitumor Activity of TrabectedinQ56942258
Post-treatment changes in hematological parameters predict response to nivolumab monotherapy in non-small cell lung cancer patientsQ57788782
High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer TherapyQ57814130
Defining T Cell States Associated with Response to Checkpoint Immunotherapy in MelanomaQ58547062
Targeting macrophages: therapeutic approaches in cancerQ58547311
Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapyQ33912938
Computational algorithm-driven evaluation of monocytic myeloid-derived suppressor cell frequency for prediction of clinical outcomesQ34016867
Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancerQ34031748
CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models.Q34279134
5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potentialQ34303159
VEGF as a mediator of tumor-associated immunodeficiencyQ34303192
Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acidQ34339243
Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanomaQ34647109
Bevacizumab plus ipilimumab in patients with metastatic melanomaQ35012765
STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.Q35263440
Activation of mitogen-activated protein kinases by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) plays an important role in macrophage stimulationQ35317995
Induction of T-cell Immunity Overcomes Complete Resistance to PD-1 and CTLA-4 Blockade and Improves Survival in Pancreatic CarcinomaQ35329190
Characterization of the in vivo immune network of IDO, tryptophan metabolism, PD-L1, and CTLA-4 in circulating immune cells in melanomaQ35507112
Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patientsQ35616397
A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma.Q35617517
Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and ImmunityQ35634752
CD40/CD154 interactions at the interface of tolerance and immunityQ35698455
Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes.Q35835489
Combined Trabectedin and anti-PD1 antibody produces a synergistic antitumor effect in a murine model of ovarian cancerQ35896426
Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenaseQ35925641
Improved survival with T cell clonotype stability after anti-CTLA-4 treatment in cancer patientsQ36020800
Safety, correlative markers, and clinical results of adjuvant nivolumab in combination with vaccine in resected high-risk metastatic melanomaQ36206582
Contribution of systemic and somatic factors to clinical response and resistance to PD-L1 blockade in urothelial cancer: An exploratory multi-omic analysis.Q36383913
Prognostic factors and outcomes in metastatic uveal melanoma treated with programmed cell death-1 or combined PD-1/cytotoxic T-lymphocyte antigen-4 inhibitionQ36413900
Serum lactate dehydrogenase as an early marker for outcome in patients treated with anti-PD-1 therapy in metastatic melanoma.Q36547923
Induction of endothelial cell apoptosis by the antivascular agent 5,6-Dimethylxanthenone-4-acetic acidQ36644621
Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic MelanomaQ36730827
Phase I/II Study of Metastatic Melanoma Patients Treated with Nivolumab Who Had Progressed after Ipilimumab.Q36759111
Immunological correlates of treatment and response in stage IV malignant melanoma patients treated with IpilimumabQ36821143
Efficacy of trabectedin (ecteinascidin-743) in advanced pretreated myxoid liposarcomas: a retrospective studyQ36856816
The prognostic landscape of genes and infiltrating immune cells across human cancersQ36857285
Therapeutic regulation of myeloid-derived suppressor cells and immune response to cancer vaccine in patients with extensive stage small cell lung cancerQ36869774
Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4.Q36973676
Transformation of the tumour microenvironment by a CD40 agonist antibody correlates with improved responses to PD-L1 blockade in a mouse orthotopic pancreatic tumour modelQ37109800
Targeting CD73 in the tumor microenvironment with MEDI9447.Q37224639
Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinomaQ37237228
Genomic correlates of response to CTLA-4 blockade in metastatic melanomaQ37319470
Relationship between interferon-gamma, indoleamine 2,3-dioxygenase, and tryptophan catabolismQ37349845
Immune monitoring of the circulation and the tumor microenvironment in patients with regionally advanced melanoma receiving neoadjuvant ipilimumabQ37548776
Inhibition of CSF-1 receptor improves the antitumor efficacy of adoptive cell transfer immunotherapyQ37626265
Nivolumab for advanced melanoma: pretreatment prognostic factors and early outcome markers during therapyQ37718376
Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapyQ37734285
Roles of Sema4D and Plexin-B1 in tumor progressionQ37790755
Regulation of lymphocyte function by adenosineQ38024675
Mechanism of all-trans retinoic acid effect on tumor-associated myeloid-derived suppressor cellsQ38296397
Development, history, and future of automated cell countersQ38353347
Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trialQ38364028
Biomarker: Predictive or Prognostic?Q38590718
PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity.Q38703214
The Complex Role of Neutrophils in Tumor Angiogenesis and MetastasisQ38721230
T Cell Cancer Therapy Requires CD40-CD40L Activation of Tumor Necrosis Factor and Inducible Nitric-Oxide-Synthase-Producing Dendritic CellsQ38746598
Biomarkers for Checkpoint InhibitionQ38754521
Predictive biomarkers for checkpoint inhibitor-based immunotherapyQ38786289
Immune Checkpoint Therapy and the Search for Predictive BiomarkersQ38816815
Immunosuppressive activities of adenosine in cancer.Q38840816
Induced PD-L1 expression mediates acquired resistance to agonistic anti-CD40 treatmentQ38916286
Antibody Blockade of Semaphorin 4D Promotes Immune Infiltration into Tumor and Enhances Response to Other Immunomodulatory TherapiesQ38917199
Molecular and Biochemical Aspects of the PD-1 Checkpoint PathwayQ38996832
Human Tumor-Infiltrating Myeloid Cells: Phenotypic and Functional DiversityQ39144794
Integrating liquid biopsies into the management of cancerQ39157824
The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targetsQ39161005
Class (I) Phosphoinositide 3-Kinases in the Tumor MicroenvironmentQ39168810
Ipilimumab treatment results in an early decrease in the frequency of circulating granulocytic myeloid-derived suppressor cells as well as their Arginase1 production.Q39201935
The prognostic value of vascular endothelial growth factor in patients with renal cell carcinoma: a systematic review of the literature and meta-analysisQ39266495
The immune contexture in cancer prognosis and treatmentQ39456999
In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapyQ40218347
Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1-targeted therapy in lung cancer patients.Q40236161
Myeloid-Derived Suppressor CellsQ40385399
Baseline Biomarkers for Outcome of Melanoma Patients Treated with PembrolizumabQ40506025
Myeloid derived suppressor and dendritic cell subsets are related to clinical outcome in prostate cancer patients treated with prostate GVAX and ipilimumabQ40713858
Baseline Peripheral Blood Biomarkers Associated with Clinical Outcome of Advanced Melanoma Patients Treated with IpilimumabQ40964128
The Ratio of Peripheral Regulatory T Cells to Lox-1 PMN-MDSC Predicts the Early Response to Anti-PD-1 Therapy in Non-Small Cell Lung Cancer PatientsQ58585965
Emerging Role of Immune Checkpoint Blockade in Pancreatic CancerQ58595922
Design of amidobenzimidazole STING receptor agonists with systemic activityQ58599932
Epacadostat Plus Pembrolizumab in Patients With Advanced Solid Tumors: Phase I Results From a Multicenter, Open-Label Phase I/II Trial (ECHO-202/KEYNOTE-037)Q59128458
Baseline neutrophils and derived neutrophil-to-lymphocyte ratio: prognostic relevance in metastatic melanoma patients receiving ipilimumabQ59489483
Activity of durvalumab plus olaparib in metastatic castration-resistant prostate cancer in men with and without DNA damage repair mutationsQ59793953
Avelumab plus Axitinib versus Sunitinib for Advanced Renal-Cell CarcinomaQ62514960
Baseline neutrophil-to-lymphocyte ratio (NLR) and derived NLR could predict overall survival in patients with advanced melanoma treated with nivolumabQ62661800
PD-L1 expression with immune-infiltrate evaluation and outcome prediction in melanoma patients treated with ipilimumabQ62661814
Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastomaQ62745893
Change in the lymphocyte-to-monocyte ratio is an early surrogate marker of the efficacy of nivolumab monotherapy in advanced non-small-cell lung cancerQ62929733
Phase 1/2 study of epacadostat in combination with ipilimumab in patients with unresectable or metastatic melanomaQ64071263
PD-L1 Expression in Systemic Immune Cell Populations as a Potential Predictive Biomarker of Responses to PD-L1/PD-1 Blockade Therapy in Lung CancerQ64085542
Synergistic effect of immune checkpoint blockade and anti-angiogenesis in cancer treatmentQ64100389
Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic TargetsQ64112523
Assessment of Blood Tumor Mutational Burden as a Potential Biomarker for Immunotherapy in Patients With Non-Small Cell Lung Cancer With Use of a Next-Generation Sequencing Cancer Gene PanelQ64247150
Automatic discovery of image-based signatures for ipilimumab response prediction in malignant melanomaQ64259329
Tim-3/galectin-9 pathway and mMDSC control primary and secondary resistances to PD-1 blockade in lung cancer patientsQ64268841
Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cellsQ71607047
Expression of Tie-2 by human monocytes and their responses to angiopoietin-2Q80358599
Immature immunosuppressive CD14+HLA-DR-/low cells in melanoma patients are Stat3hi and overexpress CD80, CD83, and DC-signQ84256128
The potential predictive value of circulating immune cell ratio and tumor marker in atezolizumab treated advanced non-small cell lung cancer patientsQ88666290
Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLCQ88973544
Clinical activity and molecular correlates of response to atezolizumab alone or in combination with bevacizumab versus sunitinib in renal cell carcinomaQ88985835
Blood cell count indexes as predictors of outcomes in advanced non-small-cell lung cancer patients treated with NivolumabQ89281994
Peripheral monocytes and neutrophils predict response to immune checkpoint inhibitors in patients with metastatic non-small cell lung cancerQ89397407
Pathologic features of response to neoadjuvant anti-PD-1 in resected non-small-cell lung carcinoma: a proposal for quantitative immune-related pathologic response criteria (irPRC)Q89456538
Predictive biomarkers for immune checkpoint blockade and opportunities for combination therapiesQ89640748
Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory DiseasesQ90206556
Programmed Cell Death Ligand 1 (PD-L1) Signaling Regulates Macrophage Proliferation and ActivationQ90252755
Myeloid immunosuppression and immune checkpoints in the tumor microenvironmentQ90703794
Immune Cell PD-L1 Colocalizes with Macrophages and Is Associated with Outcome in PD-1 Pathway Blockade TherapyQ90730277
Macrophage-Derived CXCL9 and CXCL10 Are Required for Antitumor Immune Responses Following Immune Checkpoint BlockadeQ90856138
Epigenetic prediction of response to anti-PD-1 treatment in non-small-cell lung cancer: a multicentre, retrospective analysisQ90904632
The role of PD-L1 expression as a predictive biomarker: an analysis of all US Food and Drug Administration (FDA) approvals of immune checkpoint inhibitorsQ90958052
Targeting myeloid-derived suppressor cells using all-trans retinoic acid in melanoma patients treated with IpilimumabQ91019889
Prognostic factors of daily blood examination for advanced melanoma patients treated with nivolumabQ91209500
Improving efficacy of cancer immunotherapy through targeting of macrophagesQ91330299
Antibody-Fc/FcR Interaction on Macrophages as a Mechanism for Hyperprogressive Disease in Non-small Cell Lung Cancer Subsequent to PD-1/PD-L1 BlockadeQ91392607
Neoadjuvant nivolumab modifies the tumor immune microenvironment in resectable glioblastomaQ91451450
The evolving landscape of biomarkers for checkpoint inhibitor immunotherapyQ91520697
Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell CarcinomaQ91700806
Immunological Correlates of Response to Immune Checkpoint Inhibitors in Metastatic Urothelial CarcinomaQ91862819
A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanomaQ91907652
Atezolizumab plus bevacizumab versus sunitinib in patients with previously untreated metastatic renal cell carcinoma (IMmotion151): a multicentre, open-label, phase 3, randomised controlled trialQ91958139
Mechanisms of Resistance to Immune Checkpoint Blockade: Why Does Checkpoint Inhibitor Immunotherapy Not Work for All Patients?Q92109994
A model combining clinical and genomic factors to predict response to PD-1/PD-L1 blockade in advanced urothelial carcinomaQ92133160
Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastomaQ92229967
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P921main subjectbiomarkerQ864574
P304page(s)1590
P577publication date2020-07-24
P1433published inFrontiers in ImmunologyQ27723748
P1476titleMyeloid Cells as Clinical Biomarkers for Immune Checkpoint Blockade
P478volume11

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