Gene editing and elimination of latent herpes simplex virus in vivo

scientific article published on 18 August 2020

Gene editing and elimination of latent herpes simplex virus in vivo is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2020NatCo..11.4148A
P356DOI10.1038/S41467-020-17936-5
P932PMC publication ID7435201
P698PubMed publication ID32811834

P50authorKeith R. JeromeQ57904630
Pavitra RoychoudhuryQ57904635
Daniel StoneQ61162725
Alexander L. GreningerQ81925135
Philippe DuchateauQ91272169
Martine AubertQ98564772
P2093author name stringDaniel E Strongin
Meei-Li Huang
Roman Galetto
Negar Makhsous
Anoria K Haick
Laurence Stensland
Alexander Tait
Harshana S De Silva Feelixge
Lindsay M Klouser
Michelle A Loprieno
P2860cites workNIH Image to ImageJ: 25 years of image analysisQ23319322
Targeted DNA mutagenesis for the cure of chronic viral infectionsQ24620150
Herpes simplex virus-2 transmission probability estimates based on quantity of viral sheddingQ28236882
CRISPR/Cas9-Mediated Genome Editing of Herpesviruses Limits Productive and Latent InfectionsQ28552274
Characteristics of a human cell line transformed by DNA from human adenovirus type 5Q29547863
The latent herpes simplex virus type 1 genome copy number in individual neurons is virus strain specific and correlates with reactivationQ33784836
Once-daily valacyclovir to reduce the risk of transmission of genital herpesQ34287411
Genome editing and the next generation of antiviral therapy.Q34529971
In vivo disruption of latent HSV by designer endonuclease therapyQ34540648
Meganuclease-mediated Inhibition of HSV1 Infection in Cultured CellsQ34757252
Self-complementary AAV vectors; advances and applicationsQ34804660
A5-positive primary sensory neurons are nonpermissive for productive infection with herpes simplex virus 1 in vitroQ35077500
Nuclear sensing of viral DNA, epigenetic regulation of herpes simplex virus infection, and innate immunityQ35582501
Rates of reactivation of latent herpes simplex virus from mouse trigeminal ganglia ex vivo correlate directly with viral load and inversely with number of infiltrating CD8+ T cellsQ35947667
Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneityQ36751641
Distribution of herpes simplex virus type 1 and varicella zoster virus in ganglia of the human head and neckQ37435402
Impairment in reactivation of a latency associated transcript (LAT)-deficient HSV-2 is not solely dependent on the latent viral load or the number of CD8(+) T cells infiltrating the gangliaQ37435593
In vitro Inactivation of Latent HSV by Targeted Mutagenesis Using an HSV-specific Homing EndonucleaseQ37634060
CRISPR Editing Technology in Biological and Biomedical Investigation.Q38688945
A combinational CRISPR/Cas9 gene-editing approach can halt HIV replication and prevent viral escape.Q38759997
Antiviral therapy of persistent viral infection using genome editingQ38977099
Universal real-time PCR for the detection and quantification of adeno-associated virus serotype 2-derived inverted terminal repeat sequencesQ39639189
Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systemsQ40137101
A Combinatorial CRISPR-Cas9 Attack on HIV-1 DNA Extinguishes All Infectious Provirus in Infected T Cell CulturesQ40410004
Comparison of herpes simplex virus reactivation in ganglia in vivo and in explants demonstrates quantitative and qualitative differencesQ40967821
Diversity amongst trigeminal neurons revealed by high throughput single cell sequencing.Q42366263
Intravaginal administration of herpes simplex virus type 2 to mice leads to infection of several neural and extraneural sitesQ42452335
Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencingQ42775852
Suppression of subclinical shedding of herpes simplex virus type 2 with acyclovirQ43877603
Effect of valacyclovir on viral shedding in immunocompetent patients with recurrent herpes simplex virus 2 genital herpes: a US-based randomized, double-blind, placebo-controlled clinical trialQ43886317
Spread of herpes simplex virus and distribution of latent infection after intraocular infection of the mouseQ44779391
Valacyclovir and acyclovir for suppression of shedding of herpes simplex virus in the genital tractQ45066119
Recombinant adeno-associated virus purification using novel methods improves infectious titer and yieldQ45747699
Long-term acyclovir suppression of frequently recurring genital herpes simplex virus infection. A multicenter double-blind trialQ45832697
Autonomic nervous system involvement in experimental genital infection by herpes simplex virus type 2.Q45835831
Targets of herpes simplex virus type 1 infection in a mouse corneal modelQ45861131
AAVrh10 gene therapy ameliorates central and peripheral nervous system disease in canine globoid cell leukodystrophy (Krabbe disease).Q47556407
CRISPR/Cas9 and Genome Editing for Viral Disease-Is Resistance Futile?Q52430698
Viral diversity is an obligate consideration in CRISPR/Cas9 designs for targeting the HIV reservoir.Q55654521
Potential Application of the CRISPR/Cas9 System against Herpesvirus InfectionsQ59360276
Production of dissociated sensory neuron cultures and considerations for their use in studying neuronal function and plasticityQ60681167
Herpesviral lytic gene functions render the viral genome susceptible to novel editing by CRISPR/Cas9Q83225630
Integrating single-cell transcriptomic data across different conditions, technologies, and speciesQ88243551
P4510describes a project that usesImageJQ1659584
P433issue1
P304page(s)4148
P577publication date2020-08-18
P1433published inNature CommunicationsQ573880
P1476titleGene editing and elimination of latent herpes simplex virus in vivo
P478volume11

Search more.