Inhibition of Axin1 in osteoblast precursor cells leads to defects in postnatal bone growth through suppressing osteoclast formation

scientific article published on 12 August 2020

Inhibition of Axin1 in osteoblast precursor cells leads to defects in postnatal bone growth through suppressing osteoclast formation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41413-020-0104-5
P932PMC publication ID7424530
P698PubMed publication ID32821442

P50authorKe LuQ89086800
Jian HuangQ90198877
P2093author name stringJing Wang
Di Chen
Yongjun Wang
Bing Shu
Dongfeng Zhao
Junjie Yang
Guozhi Xiao
Dan Yi
Haobo Pan
Rong Xie
Yongjian Zhao
Chunchun Xue
Shitian Zhao
P2860cites workDevelopmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification.Q52055378
Chondrocytic ephrin B2 promotes cartilage destruction by osteoclasts in endochondral ossification.Q53213163
Phagocytosis of dying chondrocytes by osteoclasts in the mouse growth plate as demonstrated by annexin-V labelling.Q54039571
Activation of beta-catenin-LEF/TCF signal pathway in chondrocytes stimulates ectopic endochondral ossification.Q54797832
Osteoprotegerin produced by osteoblasts is an important regulator in osteoclast development and functionQ74244387
Canonical Wnt signaling in osteoblasts is required for osteoclast differentiationQ79872865
Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone massQ83924358
Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradationQ24301873
Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complexQ24337717
RANK is essential for osteoclast and lymph node developmentQ24598872
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKLQ24682139
Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesisQ28248087
Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disrupted endochondral ossification and mild osteopetrosisQ28295246
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiationQ28505419
Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytesQ28505614
Generation of Axin1 conditional mutant miceQ28511054
The role of Axin2 in calvarial morphogenesis and craniosynostosisQ28511400
Essential role of beta-catenin in postnatal bone acquisitionQ28594492
Osteocytes mediate the anabolic actions of canonical Wnt/β-catenin signaling in boneQ30619950
Chondrocyte-specific ablation of Osterix leads to impaired endochondral ossificationQ33577305
Roles of Axin in the Wnt signalling pathwayQ33807025
Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasisQ33877602
Multiple functions of Osterix are required for bone growth and homeostasis in postnatal miceQ34059112
Chondroclasts are mature osteoclasts which are capable of cartilage matrix resorption.Q34287203
Regulation of bone mass by Wnt signalingQ34576629
LRP6 in mesenchymal stem cells is required for bone formation during bone growth and bone remodelingQ35755193
Loss of wnt/β-catenin signaling causes cell fate shift of preosteoblasts from osteoblasts to adipocytesQ36328528
Inhibition of Wnt signaling by the osteoblast-specific transcription factor OsterixQ36657563
In vivo analysis of Wnt signaling in boneQ36774960
Inhibition of beta-catenin signaling causes defects in postnatal cartilage developmentQ37085648
Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice.Q37092804
RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolismQ37108966
Mice with a heterozygous Lrp6 deletion have impaired fracture healingQ37232610
Axin2 controls bone remodeling through the beta-catenin-BMP signaling pathway in adult mice.Q37351761
Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT.Q38319485
The expression of osteoprotegerin and RANK ligand and the support of osteoclast formation by stromal-osteoblast lineage cells is developmentally regulatedQ40838648
Mouse axin and axin2/conductin proteins are functionally equivalent in vivoQ41813252
Chondrocyte β-catenin signaling regulates postnatal bone remodeling through modulation of osteoclast formation in a murine modelQ41972888
Wnt-mediated reciprocal regulation between cartilage and bone development during endochondral ossification.Q50767836
P304page(s)31
P577publication date2020-08-12
P1433published inBone researchQ26842189
P1476titleInhibition of Axin1 in osteoblast precursor cells leads to defects in postnatal bone growth through suppressing osteoclast formation
P478volume8

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