PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response

scientific article published on 26 August 2020

PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.7554/ELIFE.60637
P932PMC publication ID7486119
P698PubMed publication ID32844745

P50authorXu-Dong WangQ56670352
Yonghao YuQ90975755
Chiho KimQ98728928
P2860cites workCyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathwayQ24306635
STING is an endoplasmic reticulum adaptor that facilitates innate immune signallingQ24336398
STING: infection, inflammation and cancerQ26776009
Structural mechanism of cytosolic DNA sensing by cGASQ27678393
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategyQ27860519
Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing's SarcomaQ28550512
A tissue-specific atlas of mouse protein phosphorylation and expressionQ29616549
PARP inhibition: PARP1 and beyondQ29619617
Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer.Q33718199
DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicityQ33804663
Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STINGQ33983673
Trapping of PARP1 and PARP2 by Clinical PARP InhibitorsQ34309488
Immune surveillance of tumorsQ34579196
Evaluating multiplexed quantitative phosphopeptide analysis on a hybrid quadrupole mass filter/linear ion trap/orbitrap mass spectrometerQ35001243
Phosphorylation of CHIP at Ser20 by Cdk5 promotes tAIF-mediated neuronal deathQ36472440
STING-cytosolic DNA sensing: the backbone for an effective tumor radiation therapyQ36540171
The anticancer immune response: indispensable for therapeutic success?Q36677608
Inflammation-driven carcinogenesis is mediated through STINGQ37207341
Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparibQ37623863
New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPsQ38020082
Innate immune sensing and signaling of cytosolic nucleic acidsQ38198154
Synthetic lethality and cancer therapy: lessons learned from the development of PARP inhibitorsQ38262230
Regulation and function of the cGAS-STING pathway of cytosolic DNA sensingQ38959510
A Strategy to Combine Sample Multiplexing with Targeted Proteomics Assays for High-Throughput Protein Signature CharacterizationQ39033381
PARP inhibitors: Synthetic lethality in the clinicQ39182835
Cyclic GMP-AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA.Q39235226
The multifaceted roles of PARP1 in DNA repair and chromatin remodelling.Q39414183
Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence.Q40036388
Mitotic progression following DNA damage enables pattern recognition within micronuclei.Q40036392
cGAS surveillance of micronuclei links genome instability to innate immunityQ41412907
BMN 673, a novel and highly potent PARP1/2 inhibitor for the treatment of human cancers with DNA repair deficiency.Q43755302
Site-specific characterization of the Asp- and Glu-ADP-ribosylated proteomeQ45389826
Cytoplasmic chromatin triggers inflammation in senescence and cancerQ46165767
Proteomic Analysis of the Downstream Signaling Network of PARP1.Q48254511
Detection of functional protein domains by unbiased genome-wide forward genetic screening.Q52579509
Cytosolic DNA Sensing in Organismal Tumor ControlQ60548668
Role of BRCA Mutations in Cancer Treatment with Poly(ADP-ribose) Polymerase (PARP) InhibitorsQ60918179
PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancerQ63383798
PARPi Triggers the STING-Dependent Immune Response and Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade Independent of BRCAnessQ64388718
The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancerQ88286449
PARP and PARG inhibitors in cancer treatmentQ89581160
PARP Inhibitor Efficacy Depends on CD8+ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast CancerQ90251051
PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian CancerQ90428750
Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradationQ90975757
Structural basis for allosteric PARP-1 retention on DNA breaksQ91521096
Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung CancerQ91689195
Inhibition of cGAS-Mediated Interferon Response Facilitates Transgene ExpressionQ91866752
DNA sensing by the cGAS-STING pathway in health and diseaseQ92267263
PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone MarrowQ93078964
P4510describes a project that usesImageJQ1659584
P577publication date2020-08-26
P1433published ineLifeQ2000008
P1476titlePARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response
P478volume9

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cites work (P2860)
Q114870922Barriers to Immunotherapy in Ovarian Cancer: Metabolic, Genomic, and Immune Perturbations in the Tumour Microenvironment
Q104571998Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1
Q104500089Immunomodulation by targeted anticancer agents
Q112643403Targeting MUS81 promotes the anticancer effect of WEE1 inhibitor and immune checkpoint blocking combination therapy via activating cGAS/STING signaling in gastric cancer cells

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