TRPV4 channels are essential for alveolar epithelial barrier function as protection from lung edema

scientific article published on 15 September 2020

TRPV4 channels are essential for alveolar epithelial barrier function as protection from lung edema is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI.INSIGHT.134464
P932PMC publication ID7605532
P698PubMed publication ID32931478

P2093author name stringChristian Grimm
Norbert Weissmann
Alexander Dietrich
Ali Önder Yildirim
Johann Schredelseker
Thomas Gudermann
Yu-Kai Chao
Jonas Weber
Gabriela Krasteva-Christ
Suhasini Rajan
Christian Schremmer
Martina Kannler
Monika Brosien
P2860cites workOTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarityQ24290380
An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failureQ24302551
Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditionsQ24545347
Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitisQ24614844
Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptorQ24647926
Alveolar epithelial type II cell: defender of the alveolus revisitedQ24791750
Transient receptor potential channels as drug targets: from the science of basic research to the art of medicineQ26849317
Modulators of Transient Receptor Potential (TRP) Channels as Therapeutic Options in Lung DiseaseQ64230474
Isolation and primary culture of murine alveolar type II cellsQ70999865
Cytotoxic and cytostatic effects of four Annonaceae plants on human cancer cell linesQ92885457
Impaired osmotic sensation in mice lacking TRPV4Q28588195
A gene expression atlas of the central nervous system based on bacterial artificial chromosomesQ29617753
TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cellsQ30483343
Alveolar progenitor and stem cells in lung development, renewal and cancer.Q33579149
TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stressQ33655931
An alternative view of the role(s) of surfactant and the alveolar modelQ33774147
Increased vascular smooth muscle contractility in TRPC6-/- miceQ33924920
Down-regulated aquaporin 5 inhibits proliferation and migration of human epithelial ovarian cancer 3AO cellsQ34185010
Vascular TRP channels: performing under pressure and going with the flowQ34428913
TRPV4 Is Required for Hypoxic Pulmonary VasoconstrictionQ34468942
TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles.Q35044737
Ischemia-reperfusion-induced lung injury.Q35067234
TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice.Q35145453
Enolase 1 (ENO1) and protein disulfide-isomerase associated 3 (PDIA3) regulate Wnt/β-catenin-driven trans-differentiation of murine alveolar epithelial cellsQ35923444
Highly water-permeable type I alveolar epithelial cells confer high water permeability between the airspace and vasculature in rat lungQ35975792
TRPV4 channels in the human urogenital tract play a role in cell junction formation and epithelial barrier.Q36001987
Reduced migration of Ishikawa cells associated with downregulation of aquaporin-5.Q36110422
Hydrogen peroxide-induced calcium influx in lung microvascular endothelial cells involves TRPV4.Q36382147
High vascular pressure-induced lung injury requires P450 epoxygenase-dependent activation of TRPV4Q36508703
TRPP2 and TRPV4 form a polymodal sensory channel complexQ36817870
Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier: a novel mechanism of acute lung injury.Q36926550
Surfactants: past, present and future.Q37150766
TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertensionQ37234560
Lung fluid transport in aquaporin-5 knockout miceQ37303351
The great big alveolar TI cell: evolving concepts and paradigmsQ37669633
Isolation and culture of alveolar type II cellsQ37920407
Ion transport by pulmonary epitheliaQ37963340
TRPV4: physiological role and therapeutic potential in respiratory diseasesQ38262420
Transient receptor potential (TRP) channels as molecular targets in lung toxicology and associated diseasesQ38684491
Classical transient receptor potential 6 (TRPC6) channels support myofibroblast differentiation and development of experimental pulmonary fibrosisQ38785540
Phospholipase C epsilon (PLCε) induced TRPC6 activation: a common but redundant mechanism in primary podocytesQ39614603
A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery.Q40298502
Homo- and heteromeric assembly of TRPV channel subunits.Q40457827
Aquaporins and the respiratory system: advice for a lung investigatorQ40741685
Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice.Q40859359
TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cellsQ42652555
TRPV4 Regulates Tight Junctions and Affects Differentiation in a Cell Culture Model of the Corneal Epithelium.Q42805342
TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury.Q42857077
Impaired Pressure Sensation in Mice Lacking TRPV4Q44401201
Activation of TRPV4 strengthens the tight-junction barrier in human epidermal keratinocytes.Q45392731
Negative-feedback loop attenuates hydrostatic lung edema via a cGMP-dependent regulation of transient receptor potential vanilloid 4.Q46716144
Nitric Oxide-Dependent Feedback Loop Regulates Transient Receptor Potential Vanilloid 4 (TRPV4) Channel Cooperativity and Endothelial Function in Small Pulmonary ArteriesQ47257432
TRPV4 initiates the acute calcium-dependent permeability increase during ventilator-induced lung injury in isolated mouse lungs.Q50685898
Distribution of lung cell numbers and volumes between alveolar and nonalveolar tissue.Q50791172
Transient Receptor Potential Vanilloid 4 and Serum Glucocorticoid-regulated Kinase 1 Are Critical Mediators of Lung Injury in Overventilated Mice In Vivo.Q51061207
In vitro and in vivo evidence for an inflammatory role of the calcium channel TRPV4 in lung epithelium: Potential involvement in cystic fibrosis.Q51590583
On the tricks alveolar epithelial cells play to make a good lung.Q51654741
Pneumonitis and emphysema in sp-C gene targeted mice.Q51691303
Cigarette smoke-induced iBALT mediates macrophage activation in a B cell-dependent manner in COPD.Q51703615
Novel mechanisms regulating endothelial barrier function in the pulmonary microcirculationQ56964057
TRPA1 channels: expression in non-neuronal murine lung tissues and dispensability for hyperoxia-induced alveolar epithelial hyperplasiaQ57987834
TRPs in Tox: Involvement of Transient Receptor Potential-Channels in Chemical-Induced Organ Toxicity-A Structured ReviewQ58796873
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P577publication date2020-09-15
P1433published inJCI insightQ27727187
P1476titleTRPV4 channels are essential for alveolar epithelial barrier function as protection from lung edema

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