Trehalose ameliorates peritoneal fibrosis by promoting Snail degradation and inhibiting mesothelial-to-mesenchymal transition in mesothelial cells

scientific article published on 31 August 2020

Trehalose ameliorates peritoneal fibrosis by promoting Snail degradation and inhibiting mesothelial-to-mesenchymal transition in mesothelial cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-020-71230-4
P932PMC publication ID7459354
P698PubMed publication ID32868830

P50authorTaito MiyakeQ99637163
P2093author name stringKoichi Sato
Tadashi Toyama
Takashi Wada
Shuichi Kaneko
Kengo Furuichi
Yasunori Iwata
Miho Shimizu
Akinori Hara
Norihiko Sakai
Akihiro Sagara
Shinji Kitajima
Yasuyuki Shinozaki
Shiori Nakagawa
Yasutaka Kamikawa
Megumi Oshima
Taro Miyagawa
Yuta Yamamura
Akira Tamai
Hisayuki Ogura
P2860cites workDual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transitionQ24305416
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processingQ24597817
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Vitrification is essential for anhydrobiosis in an African chironomid, Polypedilum vanderplankiQ24647508
Molecular Mechanisms Underlying Peritoneal EMT and FibrosisQ26768501
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Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosisQ33556248
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Inhibition of CTGF ameliorates peritoneal fibrosis through suppression of fibroblast and myofibroblast accumulation and angiogenesisQ33906324
A crosstalk between the Smad and JNK signaling in the TGF-β-induced epithelial-mesenchymal transition in rat peritoneal mesothelial cellsQ34182159
New insights on trehalose: a multifunctional moleculeQ34182431
Lineage tracing reveals distinctive fates for mesothelial cells and submesothelial fibroblasts during peritoneal injuryQ34568791
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Myofibroblastic Conversion and Regeneration of Mesothelial Cells in Peritoneal and Liver FibrosisQ36509097
Biocompatibility of peritoneal dialysis fluid and influence of compositions on peritoneal fibrosisQ36566683
Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosisQ36753541
LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferationQ36788697
The transcription factor snail represses Crumbs3 expression and disrupts apico-basal polarity complexesQ36871543
Molecular targets in pulmonary fibrosis: the myofibroblast in focus.Q36969931
Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transitionQ36985824
Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstructionQ36991087
Autophagy and human diseasesQ37429062
SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy.Q37476025
Incidence of encapsulating peritoneal sclerosis at a single U.S. university center.Q37846654
Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington diseaseQ38345839
Fibrosis--a common pathway to organ injury and failureQ38382816
Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradationQ38836438
Preventing peritoneal membrane fibrosis in peritoneal dialysis patientsQ38855591
Specific heparanase inhibition reverses glucose-induced mesothelial-to-mesenchymal transition.Q39033979
Snail and kidney fibrosisQ39130139
Autophagy induction by trehalose counteracts cellular prion infectionQ39889113
Elevated Snail expression in human gingival fibroblasts by cyclosporine A as the possible pathogenesis for gingival overgrowthQ40862383
The Roles of Mitogen-Activated Protein Kinase Pathways in TGF-β-Induced Epithelial-Mesenchymal TransitionQ40867284
Peritoneal fibrosis and high transport are induced in mildly pre-injured peritoneum by 3,4-dideoxyglucosone-3-ene in miceQ41105742
Smad3-dependent and -independent pathways are involved in peritoneal membrane injuryQ43231611
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.Q45303665
Heat shock protein 70 protects rat peritoneal mesothelial cells from advanced glycation end-products-induced epithelial-to-mesenchymal transition through mitogen‑activated protein kinases/extracellular signal-regulated kinases and transforming growtQ46780417
Autophagy promotes fibrosis and apoptosis in the peritoneum during long-term peritoneal dialysis.Q48114520
The contribution of epithelial-mesenchymal transition to renal fibrosis differs among kidney disease modelsQ50453297
Sclerosing peritonitis: the experience in Australia.Q50628731
High-Fat Diet-Induced Lysosomal Dysfunction and Impaired Autophagic Flux Contribute to Lipotoxicity in the Kidney.Q51278227
Peritoneal dialysis and epithelial-to-mesenchymal transition of mesothelial cells.Q54792706
ESRD patients in 2004: global overview of patient numbers, treatment modalities and associated trends.Q55041285
Isolation and propagation in vitro of peritoneal mesothelial cellsQ69155356
P433issue1
P921main subjectsclerosing encapsulating peritonitisQ26805194
P304page(s)14292
P577publication date2020-08-31
P1433published inScientific ReportsQ2261792
P1476titleTrehalose ameliorates peritoneal fibrosis by promoting Snail degradation and inhibiting mesothelial-to-mesenchymal transition in mesothelial cells
P478volume10

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