Loss of HES-1 Expression Predicts a Poor Prognosis for Small Intestinal Adenocarcinoma Patients

scientific article published on 19 August 2020

Loss of HES-1 Expression Predicts a Poor Prognosis for Small Intestinal Adenocarcinoma Patients is …
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scholarly articleQ13442814

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P356DOI10.3389/FONC.2020.01427
P932PMC publication ID7466551
P698PubMed publication ID32974155

P50authorStephen M. HewittQ30361876
P2093author name stringSeung-Mo Hong
Kris Ylaya
Joon-Yong Chung
Jeong Won Kim
Sun-Young Jun
Young-Ha Oh
Hee-Kyung Chang
P2860cites workNOTCH receptors in gastric and other gastrointestinal cancers: oncogenes or tumor suppressors?Q28074478
HES and HERP families: multiple effectors of the Notch signaling pathwayQ28205103
Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' studyQ28348036
The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domainQ28577356
Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestineQ28586202
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cellsQ29614268
HES1, a target of Notch signaling, is elevated in canine osteosarcoma, but reduced in the most aggressive tumorsQ34788468
Hes1 Increases the Invasion Ability of Colorectal Cancer Cells via the STAT3-MMP14 Pathway.Q35864246
A phase II study of RO4929097 in metastatic colorectal cancerQ35910545
A population-based comparison of adenocarcinoma of the large and small intestine: insights into a rare diseaseQ35930237
Hes1: a key role in stemness, metastasis and multidrug resistanceQ36213706
Prognostic and predictive roles of KRAS mutation in colorectal cancerQ36396396
Hes1 promotes cell proliferation and migration by activating Bmi-1 and PTEN/Akt/GSK3β pathway in human colon cancerQ36629382
Notch-induced transcription factors are predictive of survival and 5-fluorouracil response in colorectal cancer patients.Q37111204
Molecular pathways: translational and therapeutic implications of the Notch signaling pathway in cancerQ38267262
Mutant KRAS promotes hyperplasia and alters differentiation in the colon epithelium but does not expand the presumptive stem cell poolQ38271066
HES1 in immunity and cancerQ38804938
HES1 promotes metastasis and predicts poor survival in patients with colorectal cancerQ38914804
Sonic Hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signalling.Q39094389
Loss of Hes1 expression is associated with poor prognosis in colorectal adenocarcinomaQ39541490
Clinicopathologic and prognostic associations of KRAS and BRAF mutations in small intestinal adenocarcinomaQ40901008
Notch3 signaling is associated with MUC5AC expression and favorable prognosis in patients with small intestinal adenocarcinomas.Q43695392
KRAS mutation correlates with accelerated metastatic progression in patients with colorectal liver metastasesQ44963530
Primary adenocarcinoma of the small intestine: presentation, prognostic factors and clinical outcomeQ45818248
p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitorsQ46193497
Mouse microRNA-23b regulates expression of Hes1 gene in P19 cells.Q51097380
Adenocarcinoma of the small intestine: a multi-institutional study of 197 surgically resected cases.Q51575529
Combined analysis of specific KRAS mutation, BRAF and microsatellite instability identifies prognostic subgroups of sporadic and hereditary colorectal cancer.Q51721033
Small bowel carcinomas in celiac or Crohn's disease: distinctive histophenotypic, molecular and histogenetic patterns.Q52764125
Genomic Profiling of Small-Bowel Adenocarcinoma.Q52859649
Ras stabilization through aberrant activation of Wnt/β-catenin signaling promotes intestinal tumorigenesis.Q54517954
Combined Loss of E-cadherin and Aberrant β-Catenin Protein Expression Correlates With a Poor Prognosis for Small Intestinal AdenocarcinomasQ56928087
Hes1-deficient mice show precocious differentiation of Paneth cells in the small intestineQ81319629
Clinical Outcomes of Small Bowel AdenocarcinomaQ90670818
Notch Signaling in Mammalian Intestinal Stem Cells: Determining Cell Fate and Maintaining HomeostasisQ91291447
Hes1 plays an essential role in Kras-driven pancreatic tumorigenesisQ91297699
Downregulation of Notch Signaling in Kras-Induced Gastric MetaplasiaQ91653941
Small bowel adenocarcinoma: Results from a nationwide prospective ARCAD-NADEGE cohort study of 347 patientsQ92486023
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P304page(s)1427
P577publication date2020-08-19
P1433published inFrontiers in OncologyQ26839986
P1476titleLoss of HES-1 Expression Predicts a Poor Prognosis for Small Intestinal Adenocarcinoma Patients
P478volume10

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