Cell Senescence, Multiple Organelle Dysfunction and Atherosclerosis

scientific article published on 23 September 2020

Cell Senescence, Multiple Organelle Dysfunction and Atherosclerosis is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3390/CELLS9102146
P932PMC publication ID7598292
P698PubMed publication ID32977446

P50authorOtilia V VieiraQ57564744
Cristiano RamosQ89156384
P2093author name stringAndré R A Marques
Gisela Machado-Oliveira
P2860cites workEndothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunctionQ24292963
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)Q24293520
Autophagy mediates the mitotic senescence transitionQ24320401
A biomarker that identifies senescent human cells in culture and in aging skin in vivoQ24562644
AtherosclerosisQ24644573
Fission and selective fusion govern mitochondrial segregation and elimination by autophagyQ24652230
Megabase chromatin domains involved in DNA double-strand breaks in vivoQ24680284
Extracellular Vesicles as New Players in Cellular SenescenceQ26738427
The crucial impact of lysosomes in aging and longevityQ26749118
From C-Reactive Protein to Interleukin-6 to Interleukin-1: Moving Upstream To Identify Novel Targets for AtheroprotectionQ26770209
Extracellular vesicles in cancer: exosomes, microvesicles and the emerging role of large oncosomesQ26825792
PGC-1 family coactivators and cell fate: roles in cancer, neurodegeneration, cardiovascular disease and retrograde mitochondria-nucleus signallingQ26864953
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
TOR signaling in growth and metabolismQ27860757
TOR, a central controller of cell growthQ27933354
Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeastQ27939948
Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespanQ28005547
Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disordersQ28067037
Cellular and molecular biology of aging endothelial cellsQ28081013
The hallmarks of agingQ28131641
Oxidants, oxidative stress and the biology of ageingQ28131725
Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1Q28255413
mTOR regulates the expression of DNA damage response enzymes in long-lived Snell dwarf, GHRKO, and PAPPA-KO miceQ28278550
Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRAQ28300188
Atherosclerosis: basic mechanisms. Oxidation, inflammation, and geneticsQ28300402
Enhanced glycogenesis is involved in cellular senescence via GSK3/GS modulationQ28564432
Senescent intimal foam cells are deleterious at all stages of atherosclerosisQ28595661
Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cellsQ28972229
The mammalian unfolded protein responseQ29547400
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighborsQ29614306
DNA damage foci at dysfunctional telomeresQ29614811
The role of autophagy in neurodegenerative diseaseQ29614834
Are cross-bridging structures involved in the bundle formation of intermediate filaments and the decrease in locomotion that accompany cell aging?Q36213362
Overexpression of the vimentin gene in transgenic mice inhibits normal lens cell differentiationQ36221672
Protein degradation in mitochondria: implications for oxidative stress, aging and disease: a novel etiological classification of mitochondrial proteolytic disorders.Q36239804
Arginase-I enhances vascular endothelial inflammation and senescence through eNOS-uncouplingQ36268285
Morphologic changes accompanying senescence of cultured human diploid cellsQ36270412
MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translationQ36405926
The coordination of nuclear and mitochondrial communication during aging and calorie restrictionQ36433751
Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture).Q36457102
Meis1 regulates the metabolic phenotype and oxidant defense of hematopoietic stem cellsQ36474576
Restoration of lysosomal pH in RPE cells from cultured human and ABCA4(-/-) mice: pharmacologic approaches and functional recoveryQ36518020
Vascular smooth muscle cell senescence in atherosclerosisQ36529123
The endoplasmic reticulum: folding, calcium homeostasis, signaling, and redox controlQ36598776
Endothelial Cell Dysfunction and the Pathobiology of AtherosclerosisQ36602763
The Ca2+/Mn2+ ion-pump PMR1 links elevation of cytosolic Ca(2+) levels to α-synuclein toxicity in Parkinson's disease modelsQ36603128
Peroxisomes and oxidative stressQ36620921
Vascular calcification: pathobiological mechanisms and clinical implicationsQ36649449
CMV seropositivity and T-cell senescence predict increased cardiovascular mortality in octogenarians: results from the Newcastle 85+ studyQ36665428
Beyond retrograde and anterograde signalling: mitochondrial-nuclear interactions as a means for evolutionary adaptation and contemporary disease susceptibilityQ36677229
Vascular cell senescence: contribution to atherosclerosisQ36699740
Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespanQ36884177
p16INK4a deficiency promotes IL-4-induced polarization and inhibits proinflammatory signaling in macrophages.Q36916423
Lysosomes and oxidative stress in aging and apoptosisQ37078535
ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulumQ37186859
Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosisQ37255799
A role for mitochondrial oxidants in stress-induced premature senescence of human vascular smooth muscle cellsQ37272651
Autophagy and aging: keeping that old broom workingQ37321185
Evaluating Health Span in Preclinical Models of Aging and Disease: Guidelines, Challenges, and Opportunities for GeroscienceQ37322066
Calorie restriction protects against experimental abdominal aortic aneurysms in mice.Q37346647
Senescence-associated exosome release from human prostate cancer cells.Q37352797
Stress-induced premature senescence of endothelial cells: a perilous state between recovery and point of no returnQ37422975
A comparative analysis of the cell biology of senescence and agingQ37473186
Downregulation of peroxiredoxin-3 by hydrophobic bile acid induces mitochondrial dysfunction and cellular senescence in human trophoblastsQ37498885
Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathwaysQ37592020
Nicotinamide enhances mitochondria quality through autophagy activation in human cells.Q45994645
Sequence-specific DNA cleavage by Fe2+-mediated fenton reactions has possible biological implicationsQ46085269
Cytoplasmic chromatin triggers inflammation in senescence and cancerQ46165767
A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineageQ46255501
Mechanisms driving the ageing heartQ46279016
Lipid mediators of autophagy in stress-induced premature senescence of endothelial cellsQ46802157
Quantifying dense bodies and lipofuscin during aging: a morphologist's perspectiveQ47218484
Lysosomal lipid accumulation from oxidized low density lipoprotein is correlated with hypertrophy of the Golgi apparatus and trans-Golgi network.Q47764891
Lysosomal sequestration of free and esterified cholesterol from oxidized low density lipoprotein in macrophages of different species.Q47764904
Inflammageing and metaflammation: The yin and yang of type 2 diabetes.Q47870904
Ionizing radiation induces long-term senescence in endothelial cells through mitochondrial respiratory complex II dysfunction and superoxide generation.Q47913083
The ATF6α arm of the Unfolded Protein Response mediates replicative senescence in human fibroblasts through a COX2/prostaglandin E2 intracrine pathway.Q47958620
Interaction between mTOR pathway inhibition and autophagy induction attenuates adriamycin-induced vascular smooth muscle cell senescence through decreased expressions of p53/p21/p16.Q47967166
Senescence and aging: Causes, consequences, and therapeutic avenuesQ48347290
Identification and characterization of an increased glycoprotein in aging: age-associated translocation of cathepsin D.Q48445810
Glycogen accumulation of the aging human brainQ48485172
Smooth Muscle Cell Fate and Plasticity in AtherosclerosisQ49551883
Short Leukocyte Telomere Length Precedes Clinical Expression of Atherosclerosis: Blood-and-Muscle ModelQ49837902
Targeting HSP90 Ameliorates Nephropathy and Atherosclerosis Through Suppression of NF-κB and STAT Signaling Pathways in Diabetic MiceQ50580624
Lysosomal enzyme activities in parenchymal and nonparenchymal liver cells isolated from young, adult and old rats.Q50958351
Transdifferentiation of vascular smooth muscle cells to macrophage-like cells during atherogenesis.Q51065835
Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic Aneurysm.Q51482469
The PI3K/Akt/mTOR pathway regulates the replicative senescence of human VSMCs.Q51516524
Vascular Smooth Muscle-Specific Progerin Expression Accelerates Atherosclerosis and Death in a Mouse Model of Hutchinson-Gilford Progeria Syndrome.Q51766620
Hallmarks of Cellular Senescence.Q51767478
Leukocyte telomere length is associated with high-risk plaques on virtual histology intravascular ultrasound and increased proinflammatory activity.Q52612656
Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis.Q52735227
Ultrastructural changes accompanying the aging of human diploid cells in cultureQ52992355
ER Stress Response in Human Cellular Models of Senescence.Q53025676
Atorvastatin induces T cell proliferation by a telomerase reverse transcriptase (TERT) mediated mechanism.Q53027311
Disturbed flow promotes endothelial senescence via a p53-dependent pathway.Q53061350
Long noncoding RNA H19 mediates melatonin inhibition of premature senescence of c-kit(+) cardiac progenitor cells by promoting miR-675.Q53125918
Quantitative assessment of markers for cell senescence.Q53345092
Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway.Q53600237
Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: effects of telomerase and oxidative stress.Q53616098
Golgin-84-associated Golgi fragmentation triggers tau hyperphosphorylation by activation of cyclin-dependent kinase-5 and extracellular signal-regulated kinase.Q54388404
A systems approach for decoding mitochondrial retrograde signaling pathways.Q54447301
Protein Carbamylation: A Marker Reflecting Increased Age-Related Cell Oxidation.Q55128365
Anti-senescence compounds: A potential nutraceutical approach to healthy agingQ56335111
Significant Role for p16INK4a in p53-Independent Telomere-Directed SenescenceQ56969662
Aging, Cell Senescence, and Chronic Disease: Emerging Therapeutic StrategiesQ57047926
Animal models of atherosclerosisQ57761322
Cardiopoietic Stem Cell Therapy in Heart FailureQ57779306
Lysosomal oxidation of LDL alters lysosomal pH, induces senescence and increases secretion of pro-inflammatory cytokines in human macrophagesQ58610946
Vascular Smooth Muscle Cell Senescence Promotes Atherosclerosis and Features of Plaque VulnerabilityQ63915322
Length-independent telomere damage drives post-mitotic cardiomyocyte senescenceQ64233922
Metabolic features and regulation in cell senescenceQ64272024
Extension of human cell lifespan by nicotinamide phosphoribosyltransferaseQ64377238
Peroxisomes: a nexus for lipid metabolism and cellular signaling.Q37633445
Cellular senescence mediates fibrotic pulmonary diseaseQ37672706
Rapamycin: one drug, many effectsQ37679469
ATF6α regulates morphological changes associated with senescence in human fibroblastsQ37708694
Pathophysiology of vascular calcification: Pivotal role of cellular senescence in vascular smooth muscle cellsQ37774469
Architecture of the mammalian GolgiQ37866547
Mitochondria and autophagy: critical interplay between the two homeostatsQ37918611
Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP).Q37969844
Fusion and fission: interlinked processes critical for mitochondrial healthQ38039146
The many routes of Golgi-dependent traffickingQ38121022
Cellular senescence and its effector programsQ38180648
Mechanisms of plaque formation and rupture.Q38218000
The unfolded protein response and cellular senescence. A review in the theme: cellular mechanisms of endoplasmic reticulum stress signaling in health and diseaseQ38300472
GSK3 inactivation is involved in mitochondrial complex IV defect in transforming growth factor (TGF) β1-induced senescenceQ38324818
Pioglitazone activates aortic telomerase and prevents stress-induced endothelial apoptosisQ38336771
Longevity Pathways (mTOR, SIRT, Insulin/IGF-1) as Key Modulatory Targets on Aging and NeurodegenerationQ38522675
DNA Damage and Repair in Vascular DiseaseQ38600660
Exenatide mitigated diet-induced vascular aging and atherosclerotic plaque growth in ApoE-deficient mice under chronic stressQ38653357
Galantamine alleviates senescence of U87 cells induced by beta-amyloid through decreasing ROS productionQ38701915
Translating the Science of Aging into Therapeutic InterventionsQ38756902
p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion.Q38788371
Impaired ATP6V0A2 expression contributes to Golgi dispersion and glycosylation changes in senescent cellsQ38816331
Chemical screening identifies ATM as a target for alleviating senescenceQ38873970
Reversal of phenotypes of cellular senescence by pan-mTOR inhibition.Q38964715
PKCδ phosphorylation is an upstream event of GSK3 inactivation-mediated ROS generation in TGF-β1-induced senescenceQ38985955
Mitochondria are targets for peroxisome-derived oxidative stress in cultured mammalian cellsQ39103215
Prelamin A accumulation in endothelial cells induces premature senescence and functional impairmentQ39132672
Robust multiparametric assessment of cellular senescenceQ39214864
Cellular Senescence: A Translational PerspectiveQ39246705
The Clinical Potential of Senolytic DrugsQ39312260
Vascular ageing: Underlying mechanisms and clinical implications.Q39380015
Studies on giant mitochondriaQ39767169
Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence.Q40036388
Restoration of peroxisomal catalase import in a model of human cellular agingQ40084094
Techniques to Induce and Quantify Cellular SenescenceQ40197071
TGF beta1 induces prolonged mitochondrial ROS generation through decreased complex IV activity with senescent arrest in Mv1Lu cells.Q40462552
Cellular aging of mitochondrial DNA-depleted cellsQ40489808
Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaksQ40593721
Mitogen-activated protein kinase p38 defines the common senescence-signalling pathwayQ40671353
Iron chelation-induced senescence-like growth arrest in hepatocyte cell lines: association of transforming growth factor beta1 (TGF-beta1)-mediated p27Kip1 expression.Q40738994
The unfolded protein response: controlling cell fate decisions under ER stress and beyondQ29615499
Association between telomere length in blood and mortality in people aged 60 years or olderQ29615532
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressorQ29615559
Cellular senescence: when bad things happen to good cellsQ29615561
A DNA damage checkpoint response in telomere-initiated senescenceQ29615919
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomasQ29616243
Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicityQ29617216
The senescence-associated secretory phenotype: the dark side of tumor suppressionQ29620106
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescenceQ29620428
Lysosome-mediated processing of chromatin in senescence.Q30541249
Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescenceQ30560506
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescenceQ33283342
Atherosclerosis profile and incidence of cardiovascular events: a population-based surveyQ33503404
Microvesicles from the plasma of elderly subjects and from senescent endothelial cells promote vascular calcificationQ33563602
Linking ER Stress to Autophagy: Potential Implications for Cancer Therapy.Q33633401
Rapamycin extends life and health in C57BL/6 miceQ33684583
Inflammation in atherosclerosis: from pathophysiology to practiceQ33709505
Senescent cells: a novel therapeutic target for aging and age-related diseasesQ33732761
Cellular senescence drives age-dependent hepatic steatosis.Q33810220
Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysisQ33860488
Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing.Q33870045
Moderate Autophagy Inhibits Vascular Smooth Muscle Cell Senescence to Stabilize Progressed Atherosclerotic Plaque via the mTORC1/ULK1/ATG13 Signal Pathway.Q33872781
Inflammatory networks during cellular senescence: causes and consequencesQ33889156
Mitochondria, oxygen free radicals, disease and ageingQ33922972
NAD+ and sirtuins in aging and diseaseQ33955066
Senescence-associated beta-galactosidase is lysosomal beta-galactosidaseQ33995193
The role of senescent cells in ageingQ34041036
Cellular senescence: from physiology to pathologyQ34041305
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.Q34043405
Mitochondria are required for pro-ageing features of the senescent phenotype.Q34046100
Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice.Q34046144
Sterol regulatory element-binding protein (SREBP)-1-mediated lipogenesis is involved in cell senescenceQ34121467
Aging, cellular senescence, and cancerQ34199776
Rapamycin slows aging in miceQ34275079
Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescenceQ34286746
The target of rapamycin (TOR) proteinsQ34287448
Integrating the DNA damage and protein stress responses during cancer development and treatment.Q64883630
Aged-senescent cells contribute to impaired heart regeneration.Q64986339
The participation of lysosomes in the transformation of smooth muscle cells to foamy cells in the aorta of cholesterol-fed rabbitsQ69147783
Mitochondrial alterations in aged rat adrenal cortical cellsQ69799789
Lysosomal activity in the aging rat liver: II. Morphometry of acid phosphatase positive dense bodiesQ70625698
Increased organization of cytoskeleton accompanying the aging of human fibroblasts in vitroQ70795796
Glycogen accumulation in tibial nerves of experimentally diabetic and aging control ratsQ71008147
Electron microscopy of human fibroblasts in tissue culture during logarithmic and confluent stages of growthQ71543506
Effects of the type of dietary fat at two levels of vitamin E in Wistar male rats during development and aging. IV. Biochemical and morphometric parameters of the heartQ72660398
Hereditary catalase deficiencies and increased risk of diabetesQ73299266
Differential expression of thymosin beta-10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF: evidence for senescent endothelial cells in vivo at sites of atherosclerosisQ73395517
Evaluation of the activities of eight lysosomal hydrolases in sera of humans, rats and pigs of different agesQ74246113
Cooperative interactions between RB and p53 regulate cell proliferation, cell senescence, and apoptosis in human vascular smooth muscle cells from atherosclerotic plaquesQ74452665
T-cell-mediated lysis of endothelial cells in acute coronary syndromesQ77595337
Enhanced apoptosis in prolonged cultures of senescent porcine pulmonary artery endothelial cellsQ77648336
Aging- and smoking-associated alteration in the relative content of mitochondrial DNA in human lungQ77779562
Age-related changes in focal adhesions lead to altered cell behavior in tendon fibroblastsQ79742016
Senescence-associated alterations of cytoskeleton: extraordinary production of vimentin that anchors cytoplasmic p53 in senescent human fibroblastsQ81462678
Measurement of telomere length by the Southern blot analysis of terminal restriction fragment lengthsQ82491708
Polymorphic variations in manganese superoxide dismutase (MnSOD), glutathione peroxidase-1 (GPX1), and catalase (CAT) contribute to elevated plasma triglyceride levels in Chinese patients with type 2 diabetes or diabetic cardiovascular diseaseQ82945501
Blockade of the nuclear factor-κB pathway in the endothelium prevents insulin resistance and prolongs life spansQ83389474
Senescent cells: a therapeutic target for cardiovascular diseaseQ88243444
Cellular Senescence in Postmitotic Cells: Beyond Growth ArrestQ88502149
Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescenceQ89453242
Senolytics improve physical function and increase lifespan in old ageQ89486364
Monoamine oxidase-A is a novel driver of stress-induced premature senescence through inhibition of parkin-mediated mitophagyQ90021806
Identification and characterization of Cardiac Glycosides as senolytic compoundsQ90857560
ER Stress Activates the NLRP3 Inflammasome: A Novel Mechanism of AtherosclerosisQ91112980
Replicative senescence of human dermal fibroblasts affects structural and functional aspects of the Golgi apparatusQ91119708
Forkhead box O3 protects the heart against paraquat-induced aging-associated phenotypes by upregulating the expression of antioxidant enzymesQ91540700
Cardiac glycosides are broad-spectrum senolyticsQ91677826
Pharmacological inhibition of mTOR attenuates replicative cell senescence and improves cellular function via regulating the STAT3-PIM1 axis in human cardiac progenitor cellsQ91787891
Inhibition of Senescence-Associated Genes Rb1 and Meis2 in Adult Cardiomyocytes Results in Cell Cycle Reentry and Cardiac Repair Post-Myocardial InfarctionQ91963816
Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosisQ92394184
Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarctionQ92669344
Mitochondrial dysfunction and cell senescence: deciphering a complex relationshipQ92847042
Vascular smooth muscle cells in atherosclerosisQ93053742
Allogeneic mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus: 4 years of experienceQ95505284
Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouseQ34323890
Autophagy and ageing: implications for age-related neurodegenerative diseases.Q34373575
Chaperone-mediated autophagy: roles in disease and agingQ34388237
Astrocyte senescence as a component of Alzheimer's diseaseQ34416365
Peroxisome senescence in human fibroblastsQ34416985
From cell senescence to age-related diseases: differential mechanisms of action of senescence-associated secretory phenotypesQ34482996
The human amniotic fluid stem cell secretome effectively counteracts doxorubicin-induced cardiotoxicity.Q34534895
Mitochondrial alterations, cellular response to oxidative stress and defective degradation of proteins in aging.Q34546103
Autophagy and human disease: emerging themesQ34620377
Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates.Q34624641
Mechanisms of cardiovascular disease in accelerated aging syndromesQ34646841
Cellular senescence: putting the paradoxes in perspectiveQ34777425
Peroxisome Metabolism and Cellular AgingQ34796539
Telomere length: a review of methods for measurement.Q34938123
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets functionQ34996827
Mathematical modeling of the role of mitochondrial fusion and fission in mitochondrial DNA maintenanceQ35022679
Risk of developing multimorbidity across all ages in an historical cohort study: differences by sex and ethnicityQ35065283
Premature aging induced by radiation exhibits pro-atherosclerotic effects mediated by epigenetic activation of CD44 expressionQ35093041
New concepts in nutraceuticals as alternative for pharmaceuticalsQ35109316
Intracellular sorting and transport of proteinsQ35131675
Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivityQ35493953
Reversal of human cellular senescence: roles of the p53 and p16 pathwaysQ35561999
Mitochondrial signaling: the retrograde responseQ35739853
Human papillomavirus E7 repression in cervical carcinoma cells initiates a transcriptional cascade driven by the retinoblastoma family, resulting in senescenceQ35784727
Oncogene-induced senescence results in marked metabolic and bioenergetic alterationsQ35954897
The yeast retrograde response as a model of intracellular signaling of mitochondrial dysfunctionQ35966892
Lamin B1 loss is a senescence-associated biomarker.Q35998585
Senescence and cytoskeleton: overproduction of vimentin induces senescent-like morphology in human fibroblastsQ40769499
Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1α-Dependent Senescence-Associated Secretory PhenotypeQ40771854
Correlation between senescence-associated beta-galactosidase expression in articular cartilage and disease severity of patients with knee osteoarthritisQ40795677
Site-specific DNA damage at the GGG sequence by UVA involves acceleration of telomere shorteningQ40813942
Quantitative and integrated proteome and microRNA analysis of endothelial replicative senescenceQ40899938
Retrograde Ca2+ signaling in C2C12 skeletal myocytes in response to mitochondrial genetic and metabolic stress: a novel mode of inter-organelle crosstalkQ40976490
Quantitative identification of senescent cells in aging and disease.Q40988773
Crosstalk between nuclear and mitochondrial genomesQ41114828
Identification of HSP90 inhibitors as a novel class of senolytics.Q41606906
Microvesicles Derived from Indoxyl Sulfate Treated Endothelial Cells Induce Endothelial Progenitor Cells Dysfunction.Q41688602
Senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cellsQ41921020
NF-κB inhibition delays DNA damage-induced senescence and aging in miceQ42220488
Uncoupling Oncogene-Induced Senescence (OIS) and DNA Damage Response (DDR) triggered by DNA hyper-replication: lessons from primary mouse embryo astrocytes (MEA).Q42374837
Endothelial cell senescence is associated with disrupted cell-cell junctions and increased monolayer permeabilityQ42423656
Chronic endoplasmic reticulum stress activates unfolded protein response in arterial endothelium in regions of susceptibility to atherosclerosis.Q42559927
Activation of SIRT1 Attenuates Klotho Deficiency-Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase ActivityQ42702475
Alteration of Golgi structure in senescent cells and its regulation by a G protein γ subunit.Q42725466
Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis.Q42832143
Replicative senescence of vascular smooth muscle cells enhances the calcification through initiating the osteoblastic transitionQ43277438
Increases of mitochondrial mass and mitochondrial genome in association with enhanced oxidative stress in human cells harboring 4,977 BP-deleted mitochondrial DNA.Q43857312
Lipid accumulation in smooth muscle cells under LDL loading is independent of LDL receptor pathway and enhanced by hypoxic conditions.Q44177947
Protein profiling of the human epidermis from the elderly reveals up-regulation of a signature of interferon-gamma-induced polypeptides that includes manganese-superoxide dismutase and the p85beta subunit of phosphatidylinositol 3-kinaseQ44367191
Mitochondrial recycling and aging of cardiac myocytes: the role of autophagocytosisQ44547129
Complex II Defect via Down-regulation of Iron-Sulfur Subunit Induces Mitochondrial Dysfunction and Cell Cycle Delay in Iron Chelation-induced Senescence-associated Growth ArrestQ44598323
Evolutionary biology: essence of mitochondria.Q44653693
Retardation of atherosclerosis by overexpression of catalase or both Cu/Zn-superoxide dismutase and catalase in mice lacking apolipoprotein E.Q45140733
Cytokeratin-related loss of cellular integrity is not a major driving force of human intrinsic skin agingQ45260861
P275copyright licenseCreative Commons AttributionQ6905323
P433issue10
P921main subjectcellular senescenceQ9075999
P577publication date2020-09-23
P1433published inCellsQ27724621
P1476titleCell Senescence, Multiple Organelle Dysfunction and Atherosclerosis
P478volume9

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