Upregulation of 5'-terminal oligopyrimidine mRNA translation upon loss of the ARF tumor suppressor

scientific article published on 17 December 2020

Upregulation of 5'-terminal oligopyrimidine mRNA translation upon loss of the ARF tumor suppressor is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-020-79379-8
P698PubMed publication ID33335292

P2093author name stringJason D Weber
Kyle A Cottrell
Ryan C Chiou
P2860cites workGene ontology: tool for the unification of biologyQ23781406
Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translationQ24337405
Physical and functional interactions of the Arf tumor suppressor protein with nucleophosmin/B23Q24629309
A non-tumor suppressor role for basal p19ARF in maintaining nucleolar structure and functionQ24642046
TopHat: discovering splice junctions with RNA-SeqQ24655505
Fast gapped-read alignment with Bowtie 2Q27860699
La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1)Q28118644
ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathwayQ28506702
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2Q29547403
HTSeq--a Python framework to work with high-throughput sequencing dataQ29614489
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARFQ29619663
Nucleolar Arf sequesters Mdm2 and activates p53Q29620244
Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylationQ30453740
Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner.Q33668452
The ARF/p53 pathwayQ33840421
Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinaseQ33890035
Human tumor suppressor p14ARF negatively regulates rRNA transcription and inhibits UBF1 transcription factor phosphorylation.Q33998894
PUROMYCIN INHIBITION OF PROTEIN SYNTHESIS: INCORPORATION OF PUROMYCIN INTO PEPTIDE CHAINSQ34402144
Hypergrowth mTORC1 signals translationally activate the ARF tumor suppressor checkpointQ35665702
A unifying model for mTORC1-mediated regulation of mRNA translation.Q35945036
Physical and functional interaction between ribosomal protein L11 and the tumor suppressor ARF.Q36006818
mTOR coordinates protein synthesis, mitochondrial activity and proliferationQ36189549
Transcriptome-wide measurement of translation by ribosome profilingQ36392252
The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer.Q36588945
mTORC1 and p53: clash of the gods?Q36604636
Comprehensive detection of human terminal oligo-pyrimidine (TOP) genes and analysis of their characteristicsQ36740139
The translational landscape of mTOR signalling steers cancer initiation and metastasisQ36873513
Overexpression of LARP1 predicts poor prognosis of colorectal cancer and is expected to be a potential therapeutic targetQ37447620
Oligopyrimidine tract at the 5' end of mammalian ribosomal protein mRNAs is required for their translational controlQ37483613
The ARF tumor-suppressor controls Drosha translation to prevent Ras-driven transformationQ37602005
Pan-cancer patterns of somatic copy number alterationQ37666205
Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis.Q38186963
UMI-tools: modeling sequencing errors in Unique Molecular Identifiers to improve quantification accuracyQ38382209
La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAsQ38853441
RNA helicase DDX5 is a p53-independent target of ARF that participates in ribosome biogenesis.Q38906649
Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.Q39451903
The ARF tumor suppressor controls ribosome biogenesis by regulating the RNA polymerase I transcription factor TTF-I.Q39698267
Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer.Q39838070
A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer.Q40053351
p19ARF directly and differentially controls the functions of c-Myc independently of p53.Q40516548
LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs.Q41042567
Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.Q41106936
Cap-proximal nucleotides via differential eIF4E binding and alternative promoter usage mediate translational response to energy stressQ42321544
Translation efficiency is a determinant of the magnitude of miRNA-mediated repressionQ42778386
ARF suppresses tumor angiogenesis through translational control of VEGFA mRNA.Q42826436
Human ARF binds E2F1 and inhibits its transcriptional activity.Q43583428
Cutadapt removes adapter sequences from high-throughput sequencing readsQ55953584
PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis toolsQ58586993
The Gene Ontology Resource: 20 years and still GOing strongQ58611616
Translational Control in CancerQ89355481
CDK1 couples proliferation with protein synthesisQ89629378
deltaTE: Detection of Translationally Regulated Genes by Integrative Analysis of Ribo-seq and RNA-seq DataQ91432470
LARP1 isoform expression in human cancer cell linesQ91890401
Translation elongation factor 2 depletion by siRNA in mouse liver leads to mTOR-independent translational upregulation of ribosomal protein genesQ99616693
P4510describes a project that usesDESeq2Q113018293
P433issue1
P304page(s)22276
P577publication date2020-12-17
P1433published inScientific ReportsQ2261792
P1476titleUpregulation of 5'-terminal oligopyrimidine mRNA translation upon loss of the ARF tumor suppressor
P478volume10

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