A non-tumor suppressor role for basal p19ARF in maintaining nucleolar structure and function

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A non-tumor suppressor role for basal p19ARF in maintaining nucleolar structure and function is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.00484-07
P932PMC publication ID2223401
P698PubMed publication ID18070929
P5875ResearchGate publication ID5777313

P50authorLeonard B. MaggiQ37375956
P2093author name stringJason D Weber
José Sanchez
Katherine Weilbaecher
Angela C Hirbe
Mary E Olanich
Alexander P Miceli
Anthony J Apicelli
Anthony J Saporita
Crystal L Schulte-Winkeler
Michael Kuchenreuther
P2860cites workTSC1 sets the rate of ribosome export and protein synthesis through nucleophosmin translationQ24297576
Nucleophosmin is essential for ribosomal protein L5 nuclear exportQ24322766
Repression of RNA polymerase I transcription by the tumor suppressor p53Q24552501
Physical and functional interactions of the Arf tumor suppressor protein with nucleophosmin/B23Q24629309
P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2Q24650492
Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1Q28141914
Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational statusQ28143274
c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase IQ28236082
Divorcing ARF and p53: an unsettled caseQ28258356
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53Q28266637
ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathwayQ28506702
Silver staining, immunofluorescence, and immunoelectron microscopic localization of nucleolar phosphoproteins B23 and C23Q28567619
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalizationQ29614701
Ribosome assembly in eukaryotesQ29615231
Genetic regulation of osteoclast development and functionQ29617421
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progressionQ29617473
Does the ribosome translate cancer?Q29618775
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARFQ29619663
Nucleolar Arf sequesters Mdm2 and activates p53Q29620244
Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesisQ30886165
N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesisQ30983520
AgNOR staining and quantificationQ33788360
Prognostic relevance of AgNORs in tumor pathologyQ33788365
Sumoylation induced by the Arf tumor suppressor: a p53-independent functionQ33821331
Human ARF protein interacts with topoisomerase I and stimulates its activityQ33943467
Overlapping functions of the pRb family in the regulation of rRNA synthesisQ33969313
Human tumor suppressor p14ARF negatively regulates rRNA transcription and inhibits UBF1 transcription factor phosphorylation.Q33998894
Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stressesQ34275810
The coupling of cell growth to the cell cycle.Q34430813
Nucleolar adaptation in human cancerQ34452742
Arf tumor suppressor promoter monitors latent oncogenic signals in vivoQ34793459
Regulators of nucleolar functionsQ35573692
At the crossroads of growth control; making ribosomal RNA.Q35804637
LOCALIZATION OF DNA COMPLEMENTARY TO RIBOSOMAL RNA IN THE NUCLEOLUS ORGANIZER REGION OF DROSOPHILA MELANOGASTERQ36396891
Induction of ARF tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1.Q36455981
Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.Q36572080
Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.Q39451903
Mechanism of repression of RNA polymerase I transcription by the retinoblastoma proteinQ40022814
p19ARF directly and differentially controls the functions of c-Myc independently of p53.Q40516548
Estimation of ribosomal RNA transcription rate in situQ40596340
Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation.Q40613625
Nucleolar Arf tumor suppressor inhibits ribosomal RNA processingQ40666241
Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF.Q40845331
Nucleophosmin (B23) targets ARF to nucleoli and inhibits its functionQ41036948
Effects of actinomycin D analogs on nucleolar phosphoprotein B23 (37,000 daltons/pI 5.1).Q42149831
Monoclonal antibodies to the mouse p19(Arf) tumor suppressor proteinQ42818785
Critical role of beta3 integrin in experimental postmenopausal osteoporosisQ43814436
Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development.Q50777362
Human Arf tumor suppressor specifically interacts with chromatin containing the promoter of rRNA genes.Q51595537
Guidelines of AgNOR quantitation. Committee on AgNOR Quantitation within the European Society of PathologyQ71626499
THE NUCLEOLUS, A SOURCE OF RIBOSOMESQ76663037
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
P304page(s)1068-1080
P577publication date2007-12-10
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleA non-tumor suppressor role for basal p19ARF in maintaining nucleolar structure and function
P478volume28

Reverse relations

cites work (P2860)
Q24329154APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.
Q34148155ARF and p53 coordinate tumor suppression of an oncogenic IFN-β-STAT1-ISG15 signaling axis.
Q54289700ARF-mediated SUMOylation of Apak antagonizes ubiquitylation and promotes its nucleolar accumulation to inhibit 47S pre-rRNA synthesis.
Q34364404Cathepsin K-Cre causes unexpected germline deletion of genes in mice
Q36845954Changes in p19Arf localization accompany apoptotic crisis during pre-B-cell transformation by Abelson murine leukemia virus
Q64066198Dual Role of the Alternative Reading Frame ARF Protein in Cancer
Q101038961Evaluating the therapeutic potential of ADAR1 inhibition for triple-negative breast cancer
Q33567807Human papillomavirus 16 oncoprotein E7 stimulates UBF1-mediated rDNA gene transcription, inhibiting a p53-independent activity of p14ARF
Q35665702Hypergrowth mTORC1 signals translationally activate the ARF tumor suppressor checkpoint
Q28082431Insights into the regulation of neuronal viability by nucleophosmin/B23
Q34683193Loss of nucleolar histone chaperone NPM1 triggers rearrangement of heterochromatin and synergizes with a deficiency in DNA methyltransferase DNMT3A to drive ribosomal DNA transcription
Q90291222Methods for Physical Characterization of Phase-Separated Bodies and Membrane-less Organelles
Q50074509Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis.
Q30577959Nucleophosmin modulates stability, activity, and nucleolar accumulation of base excision repair proteins.
Q52727234On the relationship status for Arf and NPM1 - it's complicated.
Q37733825PTENβ is an alternatively translated isoform of PTEN that regulates rDNA transcription
Q36006818Physical and functional interaction between ribosomal protein L11 and the tumor suppressor ARF.
Q38906649RNA helicase DDX5 is a p53-independent target of ARF that participates in ribosome biogenesis.
Q40078177Ribosomopathy-like properties of murine and human cancers
Q33786905The ARF tumor suppressor regulates bone remodeling and osteosarcoma development in mice
Q37602005The ARF tumor-suppressor controls Drosha translation to prevent Ras-driven transformation
Q89870482The snoRNA target of t(4;14) in multiple myeloma regulates ribosome biogenesis
Q35161251The transcription factor EGR1 localizes to the nucleolus and is linked to suppression of ribosomal precursor synthesis
Q104495369Upregulation of 5'-terminal oligopyrimidine mRNA translation upon loss of the ARF tumor suppressor

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