human | Q5 |
P106 | occupation | researcher | Q1650915 |
Q42100360 | 1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia |
Q60149833 | 3-Amino-1,5-benzodiazepinones: Potent, state-dependent sodium channel blockers with anti-epileptic activity |
Q51856780 | A novel 3-dimensional micro-ultrasound approach to automated measurement of carotid arterial plaque volume as a biomarker for experimental atherosclerosis. |
Q24535020 | A role for the melanocortin 4 receptor in sexual function |
Q34157024 | Activation of melanocortin MC(4) receptors increases erectile activity in rats ex copula |
Q34113486 | Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker |
Q34002682 | Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl]oxy]propanamide (MK-0364), in rodents |
Q60149838 | Benzazepinone Nav1.7 blockers: Potential treatments for neuropathic pain |
Q44638671 | Benzyl vinylogous amide substituted aryldihydropyridazinones and aryldimethylpyrazolones as potent and selective PDE3B inhibitors. |
Q40439424 | Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inhibitors of inducible nitric oxide synthase |
Q46894412 | Characterization of a novel and selective cannabinoid CB1 receptor inverse agonist, Imidazole 24b, in rodents |
Q44572477 | Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats |
Q74371353 | Comparison of Cardiovascular Parameters and/or Serum Chemistry and Hematology Profiles in Conscious and Anesthetized Rhesus Monkeys (Macaca mulatta) |
Q33878908 | Contribution of the tetrodotoxin-resistant voltage-gated sodium channel NaV1.9 to sensory transmission and nociceptive behavior |
Q79849541 | Cyclopentane-based human NK1 antagonists. Part 1: discovery and initial SAR |
Q51805998 | Cyclopentane-based human NK1 antagonists. Part 2: development of potent, orally active, water-soluble derivatives. |
Q44165911 | Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor ago |
Q46570240 | Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocorti |
Q45176043 | Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist |
Q60149840 | Discovery of a novel class of benzazepinone Nav1.7 blockers: Potential treatments for neuropathic pain |
Q60149816 | Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist |
Q51774599 | Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist. |
Q42973768 | Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists |
Q43263739 | Effects of sildenafil on erectile activity in mice lacking neuronal or endothelial nitric oxide synthase |
Q92687705 | Effects of the ventilatory stimulant, doxapram on human TASK-3 (KCNK9, K2P9.1) channels and TASK-1 (KCNK3, K2P3.1) channels |
Q40611630 | GAL-021 and GAL-160 are Efficacious in Rat Models of Obstructive and Central Sleep Apnea and Inhibit BKCa in Isolated Rat Carotid Body Glomus Cells |
Q38317876 | Ghrelin neutralization by a ribonucleic acid-SPM ameliorates obesity in diet-induced obese mice |
Q34493323 | Identification and Characterization of GAL-021 as a Novel Breathing Control Modulator |
Q28572004 | Identification of glucose-dependant insulin secretion targets in pancreatic beta cells by combining defined-mechanism compound library screening and siRNA gene silencing |
Q28505948 | Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2 |
Q83038827 | Inhibition of soluble epoxide hydrolase attenuates endothelial dysfunction in animal models of diabetes, obesity and hypertension |
Q79707310 | Lead optimization of 5,6-diarylpyridines as CB1 receptor inverse agonists |
Q28204017 | Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism |
Q35776539 | Melanocortin receptors and erectile function |
Q83663079 | Pharmacokinetics and pharmacodynamics of AR9281, an inhibitor of soluble epoxide hydrolase, in single- and multiple-dose studies in healthy human subjects |
Q46070903 | Pyridopyrimidine based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation |
Q51815850 | Structure-activity relationship of linear tetrapeptides Tic-DPhe-Arg-Trp-NH2 at the human melanocortin-4 receptor and effects on feeding behaviors in rat. |
Q46595954 | Synthesis and SAR of potent and orally bioavailable tert-butylpyrrolidine archetype derived melanocortin subtype-4 receptor modulators |
Q81428515 | Synthesis of functionalized 1,8-naphthyridinones and their evaluation as novel, orally active CB1 receptor inverse agonists |
Q73144717 | The proof of the pudding is in the eating: editorial focus on "Hyperphagia, not hypometabolism, causes early onset obesity in melanocortin-4-receptor knockout mice" |
Q34635467 | The role of melanocortins in body weight regulation: opportunities for the treatment of obesity |
Q74604281 | The role of melanocortins in body weight regulation: opportunities for the treatment of obesity |
Q28573173 | The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1) |
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