Insulin-like growth factor I receptor

mammalian protein found in Mus musculus

Insulin-like growth factor I receptor is …
instance of (P31):
proteinQ8054

External links are
P705Ensembl protein IDENSMUSP00000005671
P637RefSeq protein IDNP_034643
XP_006540704
XP_006540705
XP_006540706
XP_006540707
XP_006540708
XP_017177475
P352UniProt protein IDQ60751

P682biological processpositive regulation of cold-induced thermogenesisQ54810622
phosphorylationQ242736
estrous cycleQ388121
axonogenesisQ14330656
brain developmentQ14330969
positive regulation of phosphatidylinositol 3-kinase signalingQ14330982
negative regulation of apoptotic processQ14599533
positive regulation of cell population proliferationQ14633891
insulin receptor signaling pathwayQ14758913
positive regulation of cell migrationQ14758919
glucose homeostasisQ14758934
positive regulation of MAPK cascadeQ14758936
positive regulation of mitotic nuclear divisionQ14758946
positive regulation of protein kinase B signalingQ14761970
positive regulation of transcription, DNA-templatedQ14818066
protein tetramerizationQ14818074
male sex determinationQ14819278
adrenal gland developmentQ14819869
response to ethanolQ14819884
cerebellum developmentQ14820054
cellular response to glucose stimulusQ14859859
establishment of cell polarityQ14859934
anatomical structure developmentQ14860201
cellular response to insulin stimulusQ14863071
epidermis developmentQ14863096
negative regulation of DNA-binding transcription factor activityQ14863100
exocrine pancreas developmentQ14863352
transmembrane receptor protein tyrosine kinase signaling pathwayQ14863362
animal organ morphogenesisQ14863363
immune responseQ1612119
protein autophosphorylationQ3630494
mammary gland developmentQ6745783
protein phosphorylationQ7251493
insulin-like growth factor receptor signaling pathwayQ14863699
phosphatidylinositol-mediated signalingQ14863700
positive regulation of smooth muscle cell proliferationQ14863701
prostate gland epithelium morphogenesisQ14863721
positive regulation of steroid hormone biosynthetic processQ14863722
neuron projection developmentQ14864368
negative regulation of protein kinase B signalingQ14878366
cellular response to transforming growth factor beta stimulusQ14881724
negative regulation of muscle cell apoptotic processQ14882923
negative regulation of MAPK cascadeQ14883333
protein heterooligomerizationQ14884136
positive regulation of cytokinesisQ14901454
regulation of JNK cascadeQ14901455
positive regulation of DNA metabolic processQ14901459
positive regulation of osteoblast proliferationQ14903134
positive regulation of axon regenerationQ14906194
peptidyl-tyrosine autophosphorylationQ15328828
dendritic spine maintenanceQ21095095
amyloid-beta clearanceQ21111526
cellular response to insulin-like growth factor stimulusQ21118137
response to L-glutamateQ21119123
positive regulation of protein-containing complex disassemblyQ21130717
positive regulation of meiotic cell cycleQ21171628
cellular response to amyloid-betaQ22273352
cellular response to angiotensinQ22273368
negative regulation of hepatocyte apoptotic processQ22304679
negative regulation of cholangiocyte apoptotic processQ22304686
P681cell componentplasma membraneQ29548
nucleusQ40260
cytoplasmQ79899
axonQ178999
caveolaQ1051872
membraneQ14349455
intracellular membrane-bounded organelleQ14349519
neuron projectionQ14645640
neuronal cell bodyQ14645696
integral component of plasma membraneQ14859540
insulin receptor complexQ14863336
T-tubuleQ2983734
integral component of membraneQ14327652
receptor complexQ14877465
alphav-beta3 integrin-IGF-1-IGF1R complexQ21107751
P702encoded byIgf1rQ14901458
P703found in taxonhouse mouseQ83310
P527has part(s)protein kinase, ATP binding siteQ24769051
Furin-like repeatQ24774294
Receptor L-domainQ24780479
Furin-like cysteine-rich domainQ24787364
tyrosine-protein kinase, receptor class II, conserved siteQ24787466
tyrosine-protein kinase, catalytic domainQ24719835
tyrosine-protein kinase, active siteQ24738472
fibronectin type IIIQ24740327
serine-threonine/tyrosine-protein kinase, catalytic domainQ24740842
protein kinase domainQ24768234
P680molecular functionprotein bindingQ167149
insulin receptor bindingQ14758896
identical protein bindingQ14762994
ATP bindingQ14817981
protein kinase activityQ14820641
transferase activityQ14840131
nucleotide bindingQ14860365
kinase activityQ14863082
protein tyrosine kinase activityQ14863338
insulin-activated receptor activityQ14863340
insulin-like growth factor I bindingQ14863342
phosphatidylinositol 3-kinase bindingQ14863345
insulin bindingQ14863346
insulin receptor substrate bindingQ14863347
transmembrane receptor protein tyrosine kinase activityQ14863358
G-protein alpha-subunit bindingQ14891374
insulin-like growth factor-activated receptor activityQ14901451
insulin-like growth factor bindingQ14901452
P361part oftyrosine-protein kinase, insulin-like receptorQ24773020
Immunoglobulin-like foldQ24787648
Fibronectin type III superfamilyQ41797245
Receptor L-domain superfamilyQ41798034
Tyrosine-protein kinase, catalytic domain, protein familyQ83130430
Serine-threonine/tyrosine-protein kinase, catalytic domain, protein familyQ83137014
Fibronectin type III, protein familyQ83137093
Protein kinase domain, protein familyQ83138186
membrane proteinQ423042
Receptor L-domain, protein familyQ83164437
Furin-like cysteine-rich domain, protein familyQ83166305
Tyrosine-protein kinase, receptor class II, conserved site, protein familyQ95350852
Furin-like repeat, protein familyQ95352652
Tyrosine-protein kinase, active site, protein familyQ95352684
Protein kinase, ATP binding site, protein familyQ95354221
Growth factor receptor cysteine-rich domain superfamilyQ24722567
Protein kinase-like domain superfamilyQ24726164

Reverse relations

main subject (P921)
Q28592619Age-associated alterations in cardiac and skeletal muscle glucose transporters, insulin and IGF-1 receptors, and PI3-kinase protein contents in the C57BL/6 mouse
Q28506578Conditional deletion of insulin-like growth factor-I receptor in prostate epithelium
Q28587428Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development
Q28590112Decreased insulin-like growth factor I-mediated protein tyrosine phosphorylation in human olivopontocerebellar atrophy and lurcher mutant mouse
Q28512935Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance
Q39972622Essential Role of IGFIR in the Onset of Male Brown Fat Thermogenic Function: Regulation of Glucose Homeostasis by Differential Organ-Specific Insulin Sensitivity.
Q24338901Focal adhesion kinase (FAK) activates and stabilizes IGF-1 receptor
Q28589118Insulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in mice
Q28156047Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation
Q28508182Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin action
Q28507173Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition
Q28586271Lack of myotubularin (MTM1) leads to muscle hypotrophy through unbalanced regulation of the autophagy and ubiquitin-proteasome pathways
Q28512518Testis determination requires insulin receptor family function in mice
Q28505609The insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7
Q28508627The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium
Q28505191Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling
Q28593654Zinc partitions insulin-like growth factors (IGFs) from soluble IGF binding protein (IGFBP)-5 to the cell surface receptors of BC3H-1 muscle cells

Q14901458Igf1rencodesP688

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