Focal adhesion kinase (FAK) activates and stabilizes IGF-1 receptor

scientific article

Focal adhesion kinase (FAK) activates and stabilizes IGF-1 receptor is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BBRC.2009.06.088
P698PubMed publication ID19545541

P50authorPádraig D'arcyQ42856221
P2093author name stringOlle Larsson
Sandra Andersson
Bita Sehat
P2860cites workEvidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinasesQ24336665
Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motilityQ24554511
Disruption of epithelial cell-matrix interactions induces apoptosisQ24673611
Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosisQ28287406
Focal adhesion kinase: the first ten yearsQ28609173
Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient miceQ29617498
Role of ubiquitination in IGF-1 receptor signaling and degradationQ33280993
Increased expression of focal adhesion kinase in thyroid cancer: immunohistochemical studyQ33629720
FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cellsQ33986318
Insulin stimulates the tyrosine dephosphorylation of pp125 focal adhesion kinaseQ34317309
Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptorQ36696132
Sequence determinants for regulated degradation of yeast 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane proteinQ36908965
Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivoQ37365312
Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivoQ40146305
p125Fak Focal Adhesion Kinase Is a Substrate for the Insulin and Insulin-like Growth Factor-I Tyrosine Kinase ReceptorsQ41050781
Association of insulin receptor substrate-1 with integrinsQ41412716
Role of focal adhesion kinase in integrin signalingQ41672451
Insulin-like growth factor I stimulates tyrosine phosphorylation of p130(Cas), focal adhesion kinase, and paxillin. Role of phosphatidylinositol 3'-kinase and formation of a p130(Cas).Crk complexQ42826222
Dual tyrosine kinase inhibitor for focal adhesion kinase and insulin-like growth factor-I receptor exhibits anticancer effect in esophageal adenocarcinoma in vitro and in vivo.Q46482926
Clinical significance of focal adhesion kinase in resectable pancreatic cancer.Q46902911
The activated insulin-like growth factor I receptor induces depolarization in breast epithelial cells characterized by actin filament disassembly and tyrosine dephosphorylation of FAK, Cas, and paxillinQ52535990
Up-regulation of focal adhesion kinase in non-small cell lung cancerQ61698040
The roles of integrins and extracellular matrix proteins in the insulin-like growth factor I-stimulated chemotaxis of human breast cancer cellsQ70937606
Divergent insulin and platelet-derived growth factor regulation of focal adhesion kinase (pp125FAK) tyrosine phosphorylation, and rearrangement of actin stress fibersQ72191022
Tyrosine phosphorylation of paxillin and focal adhesion kinase during insulin-like growth factor-I-stimulated lamellipodial advanceQ73067647
Focal adhesion kinase and its potential involvement in tumor invasion and metastasisQ77470088
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectinsulin like growth factor 1 receptorQ2005209
Insulin-like growth factor I receptorQ14901460
peptidyl-tyrosine autophosphorylationQ15328828
P304page(s)36-41
P577publication date2009-06-21
P1433published inBiochemical and Biophysical Research CommunicationsQ864228
P1476titleFocal adhesion kinase (FAK) activates and stabilizes IGF-1 receptor
P478volume387

Reverse relations

cites work (P2860)
Q36597395Activation of the IGF1 pathway mediates changes in cellular contractility and motility in single-suture craniosynostosis
Q39384486An activity-based probe reveals dynamic protein-protein interactions mediating IGF-1R transactivation by the GABA(B) receptor.
Q92148399Cell Mechanics of Craniosynostosis
Q35489118Differential expression and signaling activation of insulin receptor isoforms A and B: A link between breast cancer and diabetes
Q35741551FAK activation is required for IGF1R-mediated regulation of EMT, migration, and invasion in mesenchymal triple negative breast cancer cells
Q52689605FES-related tyrosine kinase activates the insulin-like growth factor-1 receptor at sites of cell adhesion
Q37051008Focal adhesion kinase is required for IGF-I-mediated growth of skeletal muscle cells via a TSC2/mTOR/S6K1-associated pathway
Q35800385Focal adhesion kinase-promoted tumor glucose metabolism is associated with a shift of mitochondrial respiration to glycolysis
Q43195224GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation.
Q58773797Hypoxia-inducible transgelin 2 selects epithelial-to-mesenchymal transition and γ-radiation-resistant subtypes by focal adhesion kinase-associated insulin-like growth factor 1 receptor activation in non-small-cell lung cancer cells
Q39852454Integrin VLA-5 and FAK are Good Targets to Improve Treatment Response in the Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia
Q27009396Multifaceted Role of Insulin-Like Growth Factors and Mammalian Target of Rapamycin in Skeletal Muscle
Q30451424Neurodevelopmental effects of insulin-like growth factor signaling
Q47678215Polypharmacology-based ceritinib repurposing using integrated functional proteomics
Q36307952Protective influence of hyaluronic acid on focal adhesion kinase activity in human skin fibroblasts exposed to ethanol
Q36778833Regulation of Ligand and Shear Stress-induced Insulin-like Growth Factor 1 (IGF1) Signaling by the Integrin Pathway.
Q36972353Regulation of protumorigenic pathways by Insulin like growth factor binding protein2 and its association along with β-catenin in breast cancer lymph node metastasis
Q89267456Specific activation of mGlu2 induced IGF-1R transactivation in vitro through FAK phosphorylation
Q33694536Specific differences in migratory function of myofibroblasts isolated from Crohn's disease fistulae and strictures
Q38170895The role of FAK in tumor metabolism and therapy.
Q38569296The skeleton in the closet: actin cytoskeletal remodeling in β-cell function
Q36530869Transcriptome correlation analysis identifies two unique craniosynostosis subtypes associated with IRS1 activation.
Q83818872Type IV collagen-initiated signals provide survival and growth cues required for liver metastasis

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