An activity-based probe reveals dynamic protein-protein interactions mediating IGF-1R transactivation by the GABA(B) receptor.

scientific article

An activity-based probe reveals dynamic protein-protein interactions mediating IGF-1R transactivation by the GABA(B) receptor. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1042/BJ20120188
P698PubMed publication ID22394253

P50authorXin LiQ57148666
P2093author name stringXin Lin
Ming Jiang
Jianfeng Liu
Bing Sun
Fajun Nan
Wenhua Zhang
Han Zhao
Xiaoli Xu
Chanjuan Xu
Linhai Chen
P2860cites workDominant role of GABAB2 and Gbetagamma for GABAB receptor-mediated-ERK1/2/CREB pathway in cerebellar neurons.Q40117034
Point mutations in either subunit of the GABAB receptor confer constitutive activity to the heterodimerQ40254677
Activity-based probes that target diverse cysteine protease familiesQ40330849
Roles of Src and epidermal growth factor receptor transactivation in transient and sustained ERK1/2 responses to gonadotropin-releasing hormone receptor activationQ40663287
Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinasesQ41175767
Dynamic imaging of protease activity with fluorescently quenched activity-based probes.Q42806191
GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation.Q43195224
Importance of the gamma-aminobutyric acid(B) receptor C-termini for G-protein coupling.Q43964720
The fibroblast growth factor receptor is at the site of convergence between mu-opioid receptor and growth factor signaling pathways in rat C6 glioma cellsQ44220833
Transactivation joins multiple tracks to the ERK/MAPK cascadeQ44552387
Transactivation of Trk neurotrophin receptors by G-protein-coupled receptor ligands occurs on intracellular membranes.Q44999225
Insulin-like growth factor 1 inhibits extracellular signal-regulated kinase to promote neuronal survival via the phosphatidylinositol 3-kinase/protein kinase A/c-Raf pathway.Q46384435
Inhibition of GSK3beta is a common event in neuroprotection by different survival factorsQ46541261
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The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptorQ22253381
Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptorsQ24308093
Focal adhesion kinase (FAK) activates and stabilizes IGF-1 receptorQ24338901
Molecular tinkering of G protein-coupled receptors: an evolutionary successQ24534016
Activity-based proteomics of enzyme superfamilies: serine hydrolases as a case studyQ24634117
Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerizationQ24653438
Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor functionQ28364090
PACAP type I receptor transactivation is essential for IGF-1 receptor signalling and antiapoptotic activity in neuronsQ33276406
The G protein betagamma subunit mediates reannealing of adherens junctions to reverse endothelial permeability increase by thrombin.Q33591096
Ligands for the isolation of GABA(B) receptors [corrected] .Q33787720
Uncovering molecular mechanisms involved in activation of G protein-coupled receptorsQ33851363
FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cellsQ33986318
The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptorQ34318688
Real-time monitoring of receptor and G-protein interactions in living cells.Q34405296
Role of heteromer formation in GABAB receptor functionQ34485603
GPCR-mediated transactivation of RTKs in the CNS: mechanisms and consequencesQ35617743
GPCR interacting proteins (GIP).Q35909078
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Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning.Q36642706
Atomistic insights into rhodopsin activation from a dynamic modelQ36915142
Mitogenic signaling pathways induced by G protein-coupled receptorsQ36929839
GPCR-jacking: from a new route in RTK signalling to a new concept in GPCR activationQ37000953
Activity-based protein profiling: from enzyme chemistry to proteomic chemistryQ37119021
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complexQ37200963
Targeting of the protein interaction site between FAK and IGF-1R.Q37344395
Recent methodological advances in the discovery of GPCR-associated protein complexes.Q37356025
GPCR interacting proteins (GIPs) in the nervous system: Roles in physiology and pathologiesQ37670210
Activity-based probe for specific photoaffinity labeling gamma-aminobutyric acid B (GABAB) receptors on living cells: design, synthesis, and biological evaluationQ39986855
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectprotein-protein interactionQ896177
P304page(s)627-634
P577publication date2012-05-01
P1433published inBiochemical JournalQ864221
P1476titleAn activity-based probe reveals dynamic protein-protein interactions mediating IGF-1R transactivation by the GABA(B) receptor
P478volume443

Reverse relations

cites work (P2860)
Q35956109Chronic baclofen desensitizes GABA(B)-mediated G-protein activation and stimulates phosphorylation of kinases in mesocorticolimbic rat brain.
Q37576739Complex GABAB receptor complexes: how to generate multiple functionally distinct units from a single receptor.
Q96131906Cryo-EM structures of inactive and active GABAB receptor
Q33889093Discovery of a Negative Allosteric Modulator of GABAB Receptors
Q90438743Diversity of structure and function of GABAB receptors: a complexity of GABAB-mediated signaling
Q41446833EGFR is a pivotal regulator of thrombin-mediated inflammation in primary human nucleus pulposus culture
Q34326457GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation
Q35659477GABAB receptor upregulates fragile X mental retardation protein expression in neurons
Q37536558GCN5-like protein 1 (GCN5L1) controls mitochondrial content through coordinated regulation of mitochondrial biogenesis and mitophagy
Q35172275Single-cell chemical proteomics with an activity-based probe: identification of low-copy membrane proteins on primary neurons
Q37688636Smoking-associated lung cancer prevention by blockade of the beta-adrenergic receptor-mediated insulin-like growth factor receptor activation
Q89267456Specific activation of mGlu2 induced IGF-1R transactivation in vitro through FAK phosphorylation
Q26771727Transactivation of Epidermal Growth Factor Receptor by G Protein-Coupled Receptors: Recent Progress, Challenges and Future Research

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