Diversity of structure and function of GABAB receptors: a complexity of GABAB-mediated signaling

scientific article published on 01 January 2018

Diversity of structure and function of GABAB receptors: a complexity of GABAB-mediated signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2183/PJAB.94.026
P932PMC publication ID6374141
P698PubMed publication ID30541966

P2093author name stringMiho Terunuma
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Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channelsQ24644316
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Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerizationQ24653438
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Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501Q28201055
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Molecular cloning and characterisation of a novel GABAB-related G-protein coupled receptorQ28210217
Phenibut (beta-phenyl-GABA): a tranquilizer and nootropic drugQ28217696
The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteinsQ28235712
Hetero-oligomerization between GABAA and GABAB receptors regulates GABAB receptor traffickingQ28245383
R-phenibut binds to the α2-δ subunit of voltage-dependent calcium channels and exerts gabapentin-like anti-nociceptive effectsQ28265747
International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channelsQ28289125
Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor functionQ28364090
RGS proteins reconstitute the rapid gating kinetics of Gβγ-activated inwardly rectifying K+ channelsQ36587667
A role for GABAB receptors in excitation and inhibition of thalamocortical cells.Q36649254
Phosphinic Acid Analogs of GABA. 2. Selective, Orally Active GABAB AntagonistsQ36691386
GABA(B) receptors: synaptic functions and mechanisms of diversityQ36791464
Up-regulation of GABA(B) receptor signaling by constitutive assembly with the K+ channel tetramerization domain-containing protein 12 (KCTD12)Q37112749
Endoplasmic reticulum-associated degradation controls cell surface expression of γ-aminobutyric acid, type B receptorsQ37349020
Lys-63-linked Ubiquitination of γ-Aminobutyric Acid (GABA), Type B1, at Multiple Sites by the E3 Ligase Mind Bomb-2 Targets GABAB Receptors to Lysosomal DegradationQ37361506
Allosteric modulators of GABA(B) receptors: mechanism of action and therapeutic perspective.Q37420482
The KCTD family of proteins: structure, function, disease relevanceQ37438780
Postsynaptic GABAB receptor activity regulates excitatory neuronal architecture and spatial memoryQ37479485
NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptorQ37511744
Ca2+ activity at GABAB receptors constitutively promotes metabotropic glutamate signaling in the absence of GABA.Q37626386
Metabotropic glutamate receptors: physiology, pharmacology, and diseaseQ37670222
Nipping cue reactivity in the bud: baclofen prevents limbic activation elicited by subliminal drug cuesQ37679328
GABAB receptor coupling to G-proteins and ion channelsQ37775207
GABAB receptors: physiological functions and mechanisms of diversityQ37775211
Roles of proteolysis in regulation of GPCR functionQ38050189
Arrestins and Protein UbiquitinationQ38114216
Gαi Controls the Gating of the G Protein-Activated K+ Channel, GIRKQ38293208
Minireview: Role of intracellular scaffolding proteins in the regulation of endocrine G protein-coupled receptor signalingQ38459674
Regulation of GPCR Trafficking by UbiquitinQ38521133
Protein Phosphorylation: A Major Switch Mechanism for Metabolic Regulation.Q38615866
Organization and functions of mGlu and GABAB receptor complexesQ39025392
An activity-based probe reveals dynamic protein-protein interactions mediating IGF-1R transactivation by the GABA(B) receptor.Q39384486
GABABReceptor-Mediated Inhibition of GABAAReceptor Calcium Elevations in Developing Hypothalamic NeuronsQ39462267
Post-endocytotic Deubiquitination and Degradation of the Metabotropic γ-Aminobutyric Acid Receptor by the Ubiquitin-specific Protease 14.Q39484125
Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1)).Q39576197
17A, a novel non-coding RNA, regulates GABA B alternative splicing and signaling in response to inflammatory stimuli and in Alzheimer diseaseQ39648917
Constitutive, agonist-accelerated, recycling and lysosomal degradation of GABA(B) receptors in cortical neuronsQ39926002
Gamma-aminobutyric acid type B receptors are constitutively internalized via the clathrin-dependent pathway and targeted to lysosomes for degradationQ40117341
GABAB receptor association with the PDZ scaffold Mupp1 alters receptor stability and functionQ40201003
Subtype-selective interaction with the transcription factor CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP) regulates cell surface expression of GABA(B) receptors.Q40388680
Endogenous RGS proteins enhance acute desensitization of GABA(B) receptor-activated GIRK currents in HEK-293T cellsQ40439525
Mechanisms of allosteric modulation at GABAB receptors by CGP7930 and GS39783: effects on affinities and efficacies of orthosteric ligands with distinct intrinsic properties.Q40456690
Pertussis-toxin-sensitive Galpha subunits selectively bind to C-terminal domain of neuronal GIRK channels: evidence for a heterotrimeric G-protein-channel complex.Q40462035
Ectopically expressed gamma-aminobutyric acid receptor B is functionally down-regulated in isolated lipid raft-enriched membranesQ40517328
Phosphorylation and chronic agonist treatment atypically modulate GABAB receptor cell surface stabilityQ40602008
Recognition molecule associated carbohydrate inhibits postsynaptic GABA(B) receptors: a mechanism for homeostatic regulation of GABA release in perisomatic synapsesQ40624212
GABA(B) receptors couple directly to the transcription factor ATF4.Q40811463
Mutagenesis and modeling of the GABAB receptor extracellular domain support a venus flytrap mechanism for ligand bindingQ40957427
A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptorQ28364301
Native GABA(B) receptors are heteromultimers with a family of auxiliary subunitsQ28507921
Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integrationQ28564967
The metabotropic GABAB receptor directly interacts with the activating transcription factor 4Q28565267
GISP: a novel brain-specific protein that promotes surface expression and function of GABA(B) receptorsQ28565545
Alternative splicing generates a novel isoform of the rat metabotropic GABA(B)R1 receptorQ28566794
The sushi domains of secreted GABA(B1) isoforms selectively impair GABA(B) heteroreceptor functionQ28566971
Association of GABA(B) receptors and members of the 14-3-3 family of signaling proteinsQ28567775
A pharmacologic strategy for the treatment of nicotine addictionQ28569945
The oligomeric state sets GABA(B) receptor signalling efficacyQ28570219
Marlin-1 and conventional kinesin link GABAB receptors to the cytoskeleton and regulate receptor transportQ28576527
The role of GABAB receptor activation in absence seizures of lethargic (lh/lh) miceQ28589184
Structural analysis of the complement control protein (CCP) modules of GABA(B) receptor 1a: only one of the two CCP modules is compactly foldedQ28909851
Structural diversity of G protein-coupled receptors and significance for drug discoveryQ29616716
14-3-3 proteins: structure, function, and regulationQ29619100
Regulator of G protein signaling 6 (RGS6) protein ensures coordination of motor movement by modulating GABAB receptor signaling.Q30505394
Single-molecule analysis of fluorescently labeled G-protein-coupled receptors reveals complexes with distinct dynamics and organizationQ30532359
Epilepsy and intellectual disability linked protein Shrm4 interaction with GABABRs shapes inhibitory neurotransmissionQ30841272
GABAB receptors modulate NMDA receptor calcium signals in dendritic spinesQ30981420
Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action.Q31744913
Comparative activities of the enantiomeric GABA(B) receptor agonists CGP 44532 and 44533 in central and peripheral tissuesQ31885936
Cloning and tissue distribution of novel splice variants of the rat GABAB receptorQ31942020
The effects of GABA(B) agonists and gabapentin on mechanical hyperalgesia in models of neuropathic and inflammatory pain in the rat.Q32025408
G protein regulation of adenylate cyclaseQ33547895
Ischemia-like oxygen and glucose deprivation mediates down-regulation of cell surface γ-aminobutyric acidB receptors via the endoplasmic reticulum (ER) stress-induced transcription factor CCAAT/enhancer-binding protein (C/EBP)-homologous protein (CHQ33556292
Molecular and functional diversity of the expanding GABA-A receptor gene familyQ33691541
Intron 4 containing novel GABAB1 isoforms impair GABAB receptor functionQ33761327
Structure and ligand recognition of class C GPCRsQ33828724
Characterization of gamma-aminobutyric acid receptor GABAB(1e), a GABAB(1) splice variant encoding a truncated receptor.Q33910806
Function of GB1 and GB2 subunits in G protein coupling of GABA B receptorsQ33952116
Prolonged activation of NMDA receptors promotes dephosphorylation and alters postendocytic sorting of GABAB receptorsQ34068364
NMDA receptor-dependent GABAB receptor internalization via CaMKII phosphorylation of serine 867 in GABAB1.Q34068578
International Union of Pharmacology. XXXIII. Mammalian gamma-aminobutyric acid(B) receptors: structure and functionQ34130831
GABABR1 receptor protein expression in human mesial temporal cortex: changes in temporal lobe epilepsyQ34138555
Subunit composition, distribution and function of GABA(A) receptor subtypesQ34143787
The GABAB receptor associates with regulators of G-protein signaling 4 protein in the mouse prefrontal cortex and hypothalamusQ34179975
Functional modulation of GABAB receptors by protein kinases and receptor traffickingQ34210011
Genetic and pharmacological evidence of a role for GABA(B) receptors in the modulation of anxiety- and antidepressant-like behavior.Q34308231
Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepinesQ34317012
SGS742: the first GABA(B) receptor antagonist in clinical trialsQ34353498
In vivo effectiveness of CGP7930, a positive allosteric modulator of the GABAB receptorQ34367310
GABA(B)-receptor subtypes assemble into functional heteromeric complexes.Q34485514
Reducing effect of the positive allosteric modulator of the GABA(B) receptor, GS39,783, on alcohol self-administration in alcohol-preferring ratsQ34613495
CGP7930: a positive allosteric modulator of the GABAB receptor.Q34693009
GABABReceptor Modulation of Voltage-Sensitive Calcium Channels in Spines and DendritesQ34705003
Type-specific regulation of adenylyl cyclase by G protein beta gamma subunitsQ34993267
Studies of GABA(B) receptors labelled with [(3)H]-CGP62349 in hippocampus resected from patients with temporal lobe epilepsy.Q35044501
Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptorsQ35143358
Subchronic Administration and Combination Metabotropic Glutamate and GABAB Receptor Drug Therapy in Fragile X SyndromeQ35188148
Purinergic receptor activation facilitates astrocytic GABAB receptor calcium signallingQ35240502
The Dynamic Modulation of GABAAReceptor Trafficking and Its Role in Regulating the Plasticity of Inhibitory SynapsesQ35244210
GABAB receptor phosphorylation regulates KCTD12-induced K⁺ current desensitizationQ35471391
Mechanisms regulating membrane trafficking of G protein-coupled receptors in the endocytic pathwayQ35579630
Merging functional studies with structures of inward-rectifier K+ channelsQ35584086
The availability of surface GABA B receptors is independent of gamma-aminobutyric acid but controlled by glutamate in central neuronsQ35676795
Regulation of hippocampal synaptic plasticity by cyclic AMP-dependent protein kinasesQ35687788
Molecular structure and physiological functions of GABA(B) receptorsQ35842984
Unravelling the unusual signalling properties of the GABA(B) receptor.Q35903162
Molecular mechanisms of GABA(B) receptor activation: new insights from the mechanism of action of CGP7930, a positive allosteric modulator.Q35922936
GABAB Receptor Complex as a Potential Target for Tumor TherapyQ35956277
Don't worry 'B' happy!: a role for GABA(B) receptors in anxiety and depression.Q35998178
Ubiquitination of G protein-coupled receptors: functional implications and drug discovery.Q36294416
Opposite effects of KCTD subunit domains on GABA(B) receptor-mediated desensitizationQ36407893
Molecular diversity, trafficking and subcellular localization of GABAB receptorsQ36462270
Differential compartmentalization and distinct functions of GABAB receptor variantsQ36492579
GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2.Q40984747
Stoichiometry and assembly of a recombinant GABAA receptor subtype.Q41116066
Presynaptic inhibition of elicited neurotransmitter releaseQ41462648
Immunohistochemical localization of GABA(B) receptors in the rat central nervous systemQ41613293
gamma-Aminobutyric acid reduces the evoked release of [3H]-noradrenaline from sympathetic nerve terminals [proceedings]Q41670904
Positive regulation of GABA(B) receptors dually coupled to cyclic AMP by the allosteric agent CGP7930.Q42443418
Cyclic AMP-dependent protein kinase phosphorylation facilitates GABA(B) receptor-effector couplingQ42520588
GABAB receptor constituents revealed by tandem affinity purification from transgenic miceQ42572060
A Randomized, Placebo-Controlled Study of High-Dose Baclofen in Alcohol-Dependent Patients-The ALPADIR StudyQ42699417
Differential effects of GABAB receptor subtypes, {gamma}-hydroxybutyric Acid, and Baclofen on EEG activity and sleep regulationQ42852534
Chemistry and pharmacology of GABAB receptor ligandsQ42959792
The Sushi domains of GABAB receptors function as axonal targeting signalsQ43182544
GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation.Q43195224
Phospho-dependent functional modulation of GABA(B) receptors by the metabolic sensor AMP-dependent protein kinase.Q43244732
GABA(B) receptor activation triggers BDNF release and promotes the maturation of GABAergic synapses.Q43275671
Anticonvulsant and behavioral effects of GABAB receptor positive modulator CGP7930 in immature ratsQ43470797
CGP 36216 is a selective antagonist at GABA(B) presynaptic receptors in rat brainQ43557389
Contribution of intralaminar thalamic nuclei to spike-and-wave-discharges during spontaneous seizures in a genetic rat model of absence epilepsyQ43591891
The γ‐aminobutyric acid receptor B, but not the metabotropic glutamate receptor type‐1, associates with lipid rafts in the rat cerebellumQ43809091
Gabapentin is not a GABAB receptor agonistQ43826491
The anticonvulsant gabapentin (neurontin) does not act through gamma-aminobutyric acid-B receptors.Q44000793
GABA(B) receptor 1 polymorphism (G1465A) is associated with temporal lobe epilepsyQ44324821
Different actions of gabapentin and baclofen in hippocampus from weaver miceQ44498580
Gabapentin actions on Kir3 currents and N-type Ca2+ channels via GABAB receptors in hippocampal pyramidal cellsQ44552598
Randomized placebo-controlled trial of baclofen for cocaine dependence: preliminary effects for individuals with chronic patterns of cocaine use.Q44731806
Does gabapentin act as an agonist at native GABA(B) receptors?Q44832413
GABAB receptors do not mediate the inhibitory actions of gabapentin on the spinal reflex in ratsQ45187432
Impaired function of GABA(B) receptors in tissues from pharmacoresistant epilepsy patients.Q46005607
Changes in hippocampal GABABR1 subunit expression in Alzheimer's patients: association with Braak staging.Q46368686
Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channelQ46398883
G protein-coupled inwardly rectifying K+ channels (GIRKs) mediate postsynaptic but not presynaptic transmitter actions in hippocampal neuronsQ46524326
GABAB receptor modulation-to B or not to be B a pro-cognitive medicine?Q46558448
The positive allosteric modulator GS39783 enhances GABA(B) receptor-mediated inhibition of cyclic AMP formation in rat striatum in vivoQ46915132
RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area.Q46927228
Postsynaptic GABAB receptor signalling enhances LTD in mouse cerebellar Purkinje cellsQ46942349
Class C G protein-coupled receptors: reviving old couples with new partnersQ47127382
Lateral diffusion of the GABAB receptor is regulated by the GABAB2 C terminus.Q48123773
Postsynaptic GABABReceptors Enhance Extrasynaptic GABAAReceptor Function in Dentate Gyrus Granule CellsQ48145858
Inhibition of N‐ and P/Q‐type calcium channels by postsynaptic GABAB receptor activation in rat supraoptic neuronesQ48476725
The role of protein phosphorylation in human health and disease. The Sir Hans Krebs Medal LectureQ48575949
Opposite effects of GABAB receptor antagonists on absences and convulsive seizuresQ48637716
In vivo evidence that GABA(B) receptors are negatively coupled to adenylate cyclase in rat striatumQ48677082
Localizing 3H-GABA in Nerve Terminals of Rat Cerebral Cortex by Electron Microscopic AutoradiographyQ48846486
Involvement of GABAB receptor systems in experimental depression: baclofen but not bicuculline exacerbates helplessness in ratsQ48858517
GABAC receptor antagonists differentiate between human ρ1 and ρ2 receptors expressed in Xenopus oocytesQ48930531
Unsaturated phosphinic analogues of γ-aminobutyric acid as GABAC receptor antagonistsQ48956847
Involvement of GABA(B) receptor systems in action of antidepressants: baclofen but not bicuculline attenuates the effects of antidepressants on the forced swim test in ratsQ49113994
Desensitization of GABA(B) receptor signaling by formation of protein complexes of GABA(B2) subunit with GRK4 or GRK5.Q50644140
Anticonvulsant action of GABAB receptor positive modulator CGP7930 in immature ratsQ51814309
Mechanism of GABAB receptor-induced BDNF secretion and promotion of GABAA receptor membrane expression.Q54618524
Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) β-Dependent Phosphorylation of GABAB1 Triggers Lysosomal Degradation of GABAB Receptors via Mind Bomb-2 (MIB2)-Mediated Lys-63-Linked Ubiquitination.Q54976716
GABAB receptor antagonists elevate both mRNA and protein levels of the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) but not neurotrophin-3 (NT-3) in brain and spinal cord of ratsQ57833023
Interdomain Contact Regions and Angles Between Adjacent Short Consensus Repeat DomainsQ59244411
Evidence for oligomerization between GABAB receptors and GIRK channels containing the GIRK1 and GIRK3 subunitsQ60049914
P433issue10
P921main subjectsignal transductionQ828130
P304page(s)390-411
P577publication date2018-01-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inProceedings of the Japan Academy, Series BQ2675209
P1476titleDiversity of structure and function of GABAB receptors: a complexity of GABAB-mediated signaling
P478volume94

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cites work (P2860)
Q92589754Amyloid Precursor Protein (APP) and GABAergic Neurotransmission
Q97066870Exciting Complexity: The Role of Motor Circuit Elements in ALS Pathophysiology
Q90440063Heterosynaptic GABAB Receptor Function within Feedforward Microcircuits Gates Glutamatergic Transmission in the Nucleus Accumbens Core

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