Gamma-aminobutyric acid type B receptors are constitutively internalized via the clathrin-dependent pathway and targeted to lysosomes for degradation

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Gamma-aminobutyric acid type B receptors are constitutively internalized via the clathrin-dependent pathway and targeted to lysosomes for degradation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M702626200
P698PubMed publication ID17581821

P2093author name stringDietmar Benke
Thomas Grampp
Kathrin Sauter
Branko Markovic
P2860cites workHeterodimerization is required for the formation of a functional GABA(B) receptorQ22008591
Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1Q22010017
Coordinated action of NSF and PKC regulates GABAB receptor signaling efficacyQ24337899
Phosphorylation-independent desensitization of GABA(B) receptor by GRK4Q24671065
Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activityQ28138682
Clathrin-coated vesicle formation and protein sorting: an integrated processQ29619729
Caveolin, a protein component of caveolae membrane coatsQ29619795
Induction of mutant dynamin specifically blocks endocytic coated vesicle formationQ29620182
Expression of GABAB receptors in magnocellular neurosecretory cells of male, virgin female and lactating ratsQ33216766
GABA(B)-receptor subtypes assemble into functional heteromeric complexes.Q34485514
Role of heteromer formation in GABAB receptor functionQ34485603
The ins and outs of G protein-coupled receptor traffickingQ35183866
Desensitization of G protein-coupled receptors and neuronal functionsQ35817048
Molecular structure and physiological functions of GABA(B) receptorsQ35842984
GABA(B) receptor alterations as indicators of physiological and pharmacological functionQ35903170
Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formationQ36233556
Filipin-sensitive caveolae-mediated transport in endothelium: reduced transcytosis, scavenger endocytosis, and capillary permeability of select macromoleculesQ36234903
cAMP response element-binding protein, activating transcription factor-4, and upstream stimulatory factor differentially control hippocampal GABABR1a and GABABR1b subunit gene expression through alternative promoters.Q38339202
Acidification of the endocytic and exocytic pathwaysQ39459758
Effects of exogenous amines on mammalian cells, with particular reference to membrane flowQ40169902
ApoER2 is endocytosed by a clathrin-mediated process involving the adaptor protein Dab2 independent of its Rafts' associationQ40385056
Subtype-selective interaction with the transcription factor CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP) regulates cell surface expression of GABA(B) receptors.Q40388680
Endogenous RGS proteins enhance acute desensitization of GABA(B) receptor-activated GIRK currents in HEK-293T cellsQ40439525
Ectopically expressed gamma-aminobutyric acid receptor B is functionally down-regulated in isolated lipid raft-enriched membranesQ40517328
Phosphorylation and chronic agonist treatment atypically modulate GABAB receptor cell surface stabilityQ40602008
GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2.Q40984747
Developmental changes of agonist affinity at GABABR1 receptor variants in rat brain.Q41003136
Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formationQ41570746
Agonist-induced desensitization and endocytosis of heterodimeric GABAB receptors in CHO-K1 cellsQ44668603
gamma-aminobutyric acid type B receptor splice variant proteins GBR1a and GBR1b are both associated with GBR2 in situ and display differential regional and subcellular distributionQ48116576
GABAB-receptor splice variants GB1a and GB1b in rat brain: developmental regulation, cellular distribution and extrasynaptic localization.Q48248590
Desensitization of GABA(B) receptor signaling by formation of protein complexes of GABA(B2) subunit with GRK4 or GRK5.Q50644140
Independent maturation of the GABA(B) receptor subunits GABA(B1) and GABA(B2) during postnatal development in rodent brainQ52088153
Arrestin is required for agonist-induced trafficking of voltage-dependent calcium channelsQ56747585
P433issue33
P407language of work or nameEnglishQ1860
P304page(s)24157-24165
P577publication date2007-06-20
P1433published inJournal of Biological ChemistryQ867727
P1476titleGamma-aminobutyric acid type B receptors are constitutively internalized via the clathrin-dependent pathway and targeted to lysosomes for degradation
P478volume282

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cites work (P2860)
Q35085150-Aminobutyric Acid Type B (GABAB) Receptor Internalization Is Regulated by the R2 Subunit
Q24318611A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5)
Q42146851Agonist- and Ca2+-dependent Desensitization of TRPV1 Channel Targets the Receptor to Lysosomes for Degradation
Q37336577Alpha9 nicotinic acetylcholine receptors and the treatment of pain
Q54976716Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) β-Dependent Phosphorylation of GABAB1 Triggers Lysosomal Degradation of GABAB Receptors via Mind Bomb-2 (MIB2)-Mediated Lys-63-Linked Ubiquitination.
Q37576739Complex GABAB receptor complexes: how to generate multiple functionally distinct units from a single receptor.
Q36533004Cortical stimulation causes long-term changes in H-reflexes and spinal motoneuron GABA receptors.
Q42712411Differential phosphorylation signals control endocytosis of GPR15
Q42005893Differential regulation of GABAB receptor trafficking by different modes of N-methyl-D-aspartate (NMDA) receptor signaling.
Q33637415Direct interaction of GABAB receptors with M2 muscarinic receptors enhances muscarinic signaling
Q90438743Diversity of structure and function of GABAB receptors: a complexity of GABAB-mediated signaling
Q37349020Endoplasmic reticulum-associated degradation controls cell surface expression of γ-aminobutyric acid, type B receptors
Q39361948GABAB receptors do not internalize after baclofen treatment, possibly due to a lack of β‐arrestin association: Study with a real‐time visualizing assay
Q39958944GISP binding to TSG101 increases GABA receptor stability by down-regulating ESCRT-mediated lysosomal degradation
Q58776552Genome-scale identification of cellular pathways required for cell surface recognition
Q35763315Large putative PEST-like sequence motif at the carboxyl tail of human calcium receptor directs lysosomal degradation and regulates cell surface receptor level
Q37361506Lys-63-linked Ubiquitination of γ-Aminobutyric Acid (GABA), Type B1, at Multiple Sites by the E3 Ligase Mind Bomb-2 Targets GABAB Receptors to Lysosomal Degradation
Q37775206Mechanisms of GABAB receptor exocytosis, endocytosis, and degradation
Q38007481Modulation of cell surface GABA(B) receptors by desensitization, trafficking and regulated degradation
Q34440710Morphine- and CaMKII-dependent enhancement of GIRK channel signaling in hippocampal neurons
Q34068578NMDA receptor-dependent GABAB receptor internalization via CaMKII phosphorylation of serine 867 in GABAB1.
Q33749853Neuronal Chloride Regulation via KCC2 Is Modulated through a GABAB Receptor Protein Complex.
Q39484125Post-endocytotic Deubiquitination and Degradation of the Metabotropic γ-Aminobutyric Acid Receptor by the Ubiquitin-specific Protease 14.
Q34068364Prolonged activation of NMDA receptors promotes dephosphorylation and alters postendocytic sorting of GABAB receptors
Q28477869Regulation of interleukin-10 receptor ubiquitination and stability by beta-TrCP-containing ubiquitin E3 ligase
Q42058468Sustained Glutamate Receptor Activation Down-regulates GABAB Receptors by Shifting the Balance from Recycling to Lysosomal Degradation
Q35676795The availability of surface GABA B receptors is independent of gamma-aminobutyric acid but controlled by glutamate in central neurons
Q39148904The protein ERp57 contributes to EGF receptor signaling and internalization in MDA-MB-468 breast cancer cells.
Q40455623Tracking cell surface GABAB receptors using an alpha-bungarotoxin tag
Q33980550Transport along the dendritic endoplasmic reticulum mediates the trafficking of GABAB receptors
Q35186220Ubiquitination in postsynaptic function and plasticity
Q36616412Ubiquitination of Neurotransmitter Receptors and Postsynaptic Scaffolding Proteins
Q37112749Up-regulation of GABA(B) receptor signaling by constitutive assembly with the K+ channel tetramerization domain-containing protein 12 (KCTD12)

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