Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function

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Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/EMBOJ/20.9.2152
P932PMC publication ID125244
P698PubMed publication ID11331581
P5875ResearchGate publication ID232774336

P50authorJean-Philippe PinQ33113596
Julie KniazeffQ61827410
Jaroslav BlahošQ71143537
P2093author name stringBettler B
Rovelli G
Prézeau L
Galvez T
Duthey B
P2860cites workHeterodimerization is required for the formation of a functional GABA(B) receptorQ22008591
Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptorsQ24308093
Mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidismQ24320383
Molecular tinkering of G protein-coupled receptors: an evolutionary successQ24534016
The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFxQ24673707
Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptorQ27627995
Ca(2+) requirement for high-affinity gamma-aminobutyric acid (GABA) binding at GABA(B) receptors: involvement of serine 269 of the GABA(B)R1 subunitQ28371791
The metabotropic GABAB receptor directly interacts with the activating transcription factor 4Q28565267
The C-terminal domains of the GABA(b) receptor subunits mediate intracellular trafficking but are not required for receptor signaling.Q31840052
Intracellular Retention of Recombinant GABABReceptorsQ32012231
New perspectives for the development of selective metabotropic glutamate receptor ligands.Q33709295
A trafficking checkpoint controls GABA(B) receptor heterodimerizationQ33913403
Functional significance of oligomerization of G-protein-coupled receptors.Q33944849
Signal transduction by GABA(B) receptor heterodimersQ34047419
GCRDb: a G-protein-coupled receptor databaseQ34333530
Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alphaQ34355922
Role of the Second and Third Intracellular Loops of Metabotropic Glutamate Receptors in Mediating Dual Signal Transduction ActivationQ34458882
GABA(B)-receptor subtypes assemble into functional heteromeric complexes.Q34485514
Role of heteromer formation in GABAB receptor functionQ34485603
Intermolecular interactions between dimeric calcium-sensing receptor monomers are important for its normal functionQ35061467
Domains involved in the specificity of G protein activation in phospholipase C-coupled metabotropic glutamate receptors.Q36763220
C-terminal interaction is essential for surface trafficking but not for heteromeric assembly of GABA(b) receptors.Q40830560
Amino acids in the second and third intracellular loops of the parathyroid Ca2+-sensing receptor mediate efficient coupling to phospholipase C.Q40886949
The heteromeric GABA-B receptor recognizes G-protein alpha subunit C-terminiQ40913899
Mutagenesis and modeling of the GABAB receptor extracellular domain support a venus flytrap mechanism for ligand bindingQ40957427
GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2.Q40984747
The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteinsQ41074853
How receptors talk to trimeric G proteinsQ41382832
The N-terminal domain of gamma-aminobutyric Acid(B) receptors is sufficient to specify agonist and antagonist binding.Q42058308
Three-dimensional model of the extracellular domain of the type 4a metabotropic glutamate receptor: new insights into the activation processQ42640637
A simple method to transfer plasmid DNA into neuronal primary cultures: functional expression of the mGlu5 receptor in cerebellar granule cellsQ48125189
The second intracellular loop of metabotropic glutamate receptor 1 cooperates with the other intracellular domains to control coupling to G-proteins.Q49021662
Atomic structures of periplasmic binding proteins and the high-affinity active transport systems in bacteriaQ54099620
Metabotropic glutamate receptor 5 is a disulfide-linked dimerQ71763241
Phosphinic Acid Analogs of GABA. 1. New Potent and Selective GABAB AgonistsQ71998473
A novel site on the Galpha -protein that recognizes heptahelical receptorsQ73067495
Mapping the agonist-binding site of GABAB type 1 subunit sheds light on the activation process of GABAB receptorsQ74312772
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)2152-2159
P577publication date2001-05-01
P1433published inThe EMBO JournalQ1278554
P1476titleAllosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function
P478volume20

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