GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation

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GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation is …
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scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...739698B
P356DOI10.1371/JOURNAL.PONE.0039698
P932PMC publication ID3386256
P698PubMed publication ID22761875
P5875ResearchGate publication ID228116613

P2093author name stringJianfeng Liu
Qian Sun
Siluo Huang
Yunyun Wang
Wenhua Zhang
Lei Chun
Haijun Tu
Chanjuan Xu
Guillaume A Baloucoune
P2860cites workThe expression of GABA(B1) and GABA(B2) receptor subunits in the cNS differs from that in peripheral tissuesQ74341548
Heterodimerization is required for the formation of a functional GABA(B) receptorQ22008591
Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptorsQ24308093
Distribution of the GABA(B) receptor subunit gb2 in rat CNSQ28139311
Hetero-oligomerization between GABAA and GABAB receptors regulates GABAB receptor traffickingQ28245383
Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor functionQ28364090
A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptorQ28364301
Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integrationQ28564967
GISP: a novel brain-specific protein that promotes surface expression and function of GABA(B) receptorsQ28565545
Evolution of the class C GPCR Venus flytrap modules involved positive selected functional divergenceQ28754701
Cloning and tissue distribution of a novel isoform of the rat GABA(B)R1 receptor subunitQ30661325
The C-terminal domains of the GABA(b) receptor subunits mediate intracellular trafficking but are not required for receptor signaling.Q31840052
Cloning and tissue distribution of novel splice variants of the rat GABAB receptorQ31942020
Characterization of gamma-aminobutyric acid receptor GABAB(1e), a GABAB(1) splice variant encoding a truncated receptor.Q33910806
A trafficking checkpoint controls GABA(B) receptor heterodimerizationQ33913403
Positive regulation by GABA(B)R1 subunit of leptin expression through gene transactivation in adipocytes.Q33927260
Function of GB1 and GB2 subunits in G protein coupling of GABA B receptorsQ33952116
GABAB receptors: a new paradigm in G protein signalingQ34086468
The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptorQ34318688
GABA(B)-receptor subtypes assemble into functional heteromeric complexes.Q34485514
Role of heteromer formation in GABAB receptor functionQ34485603
Glutamate and GABA receptor signalling in the developing brain.Q35979714
An activity-based probe reveals dynamic protein-protein interactions mediating IGF-1R transactivation by the GABA(B) receptor.Q39384486
GABA-B(1) receptors are coupled to the ERK1/2 MAP kinase pathway in the absence of GABA-B(2) subunitsQ39909453
Dominant role of GABAB2 and Gbetagamma for GABAB receptor-mediated-ERK1/2/CREB pathway in cerebellar neurons.Q40117034
Down-regulation of IGF-IR using small, interfering, hairpin RNA (siRNA) inhibits growth of human lung cancer cell line A549 in vitro and in nude miceQ40188539
Interactions between GABA-B1 receptors and Kir 3 inwardly rectifying potassium channels.Q40261401
Subcellular distribution of GABA(B) receptor homo- and hetero-dimers.Q40477512
The heteromeric GABA-B receptor recognizes G-protein alpha subunit C-terminiQ40913899
GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2.Q40984747
ERK Activation by G-protein-coupled Receptors in Mouse Brain Is Receptor Identity-specificQ42515402
GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation.Q43195224
Epileptogenesis and enhanced prepulse inhibition in GABA(B1)-deficient miceQ43646279
Redistribution of GABAB(1) protein and atypical GABAB responses in GABAB(2)-deficient mice.Q47230908
Compartmentalization of the GABAB receptor signaling complex is required for presynaptic inhibition at hippocampal synapses.Q48924436
IFN-beta1a modulates the expression of CTLA-4 and CD28 splice variants in human mononuclear cells: induction of soluble isoformsQ56904900
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)e39698
P577publication date2012-06-28
P1433published inPLOS OneQ564954
P1476titleGABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation
P478volume7

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cites work (P2860)
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Q37576739Complex GABAB receptor complexes: how to generate multiple functionally distinct units from a single receptor.
Q96131906Cryo-EM structures of inactive and active GABAB receptor
Q42046800Effect of PLCε gene silencing on inhibiting the cancerous transformation of ulcerative colitis
Q35172275Single-cell chemical proteomics with an activity-based probe: identification of low-copy membrane proteins on primary neurons
Q41574564Towards a Better Understanding of GABAergic Remodeling in Alzheimer's Disease

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