| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2005PNAS..10217495G |
| P356 | DOI | 10.1073/PNAS.0508950102 |
| P932 | PMC publication ID | 1287488 |
| P698 | PubMed publication ID | 16301531 |
| P5875 | ResearchGate publication ID | 7466326 |
| P2093 | author name string | Jonathan A Javitch | |
| Lei Shi | |||
| Wen Guo | |||
| Harel Weinstein | |||
| Marta Filizola | |||
| P2860 | cites work | G-protein-coupled receptor heterodimerization modulates receptor function | Q24603239 |
| Heteromeric association creates a P2Y-like adenosine receptor | Q24629017 | ||
| Crystal structure of rhodopsin: A G protein-coupled receptor | Q27625972 | ||
| Evidence for negative binding cooperativity within CCR5-CCR2b heterodimers | Q51822453 | ||
| Rhodopsin dimers in native disc membranes | Q59056014 | ||
| Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin | Q71669056 | ||
| Movement of retinal along the visual transduction path | Q73919513 | ||
| GABA(B2) is essential for g-protein coupling of the GABA(B) receptor heterodimer | Q74596023 | ||
| Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor | Q27627995 | ||
| Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+. | Q27638103 | ||
| VMD: visual molecular dynamics | Q27860554 | ||
| Heterodimerization of mu and delta opioid receptors: A role in opiate synergy | Q28143344 | ||
| Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function | Q28364090 | ||
| A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptor | Q28364301 | ||
| The fourth transmembrane segment of the dopamine D2 receptor: accessibility in the binding-site crevice and position in the transmembrane bundle | Q28509877 | ||
| Structural changes in lumirhodopsin and metarhodopsin I studied by their photoreactions at 77 K. | Q30333178 | ||
| Structure-based analysis of GPCR function: evidence for a novel pentameric assembly between the dimeric leukotriene B4 receptor BLT1 and the G-protein | Q31144738 | ||
| Uncovering molecular mechanisms involved in activation of G protein-coupled receptors | Q33851363 | ||
| Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology. | Q33966353 | ||
| Crosslinking of membrane-embedded cysteines reveals contact points in the EmrE oligomer | Q34155142 | ||
| Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes | Q34333541 | ||
| Preferential formation of MT1/MT2 melatonin receptor heterodimers with distinct ligand interaction properties compared with MT2 homodimers | Q34334835 | ||
| D1 and D2 dopamine receptors form heterooligomers and cointernalize after selective activation of either receptor | Q34422279 | ||
| Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function | Q34504071 | ||
| The binding site of aminergic G protein-coupled receptors: the transmembrane segments and second extracellular loop | Q34504076 | ||
| Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors | Q35143358 | ||
| Oligomerization of G protein-coupled receptors: past, present, and future | Q35546811 | ||
| Roles of G-protein-coupled receptor dimerization | Q35622424 | ||
| G protein-coupled receptor dimerization: function and ligand pharmacology | Q35814850 | ||
| The structure and dynamics of GPCR oligomers: a new focus in models of cell-signaling mechanisms and drug design. | Q36256045 | ||
| Electron crystallography reveals the structure of metarhodopsin I. | Q40018770 | ||
| Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity | Q40423659 | ||
| Bioluminescence resonance energy transfer reveals ligand-induced conformational changes in CXCR4 homo- and heterodimers. | Q40474872 | ||
| Closed state of both binding domains of homodimeric mGlu receptors is required for full activity. | Q40538867 | ||
| Dopamine D1 and D2 receptor Co-activation generates a novel phospholipase C-mediated calcium signal | Q40552669 | ||
| Identification of amino acid residues crucial for chemokine receptor dimerization. | Q40600436 | ||
| The human dopamine transporter forms a tetramer in the plasma membrane: cross-linking of a cysteine in the fourth transmembrane segment is sensitive to cocaine analogs | Q40629961 | ||
| D2 dopamine receptor homodimerization is mediated by multiple sites of interaction, including an intermolecular interaction involving transmembrane domain 4. | Q40634567 | ||
| Cis- and trans-activation of hormone receptors: the LH receptor | Q40728230 | ||
| The forgotten serine. A critical role for Ser-2035.42 in ligand binding to and activation of the beta 2-adrenergic receptor. | Q40858064 | ||
| Evidence that antipsychotic drugs are inverse agonists at D2 dopamine receptors | Q41107457 | ||
| Three-dimensional structure of an invertebrate rhodopsin and basis for ordered alignment in the photoreceptor membrane. | Q41630425 | ||
| Dopamine D2 receptor dimers and receptor-blocking peptides | Q42063592 | ||
| The intracellular loops of the GB2 subunit are crucial for G-protein coupling of the heteromeric gamma-aminobutyrate B receptor | Q44072171 | ||
| The fourth transmembrane segment forms the interface of the dopamine D2 receptor homodimer. | Q44259028 | ||
| Structural models for dimerization of G-protein coupled receptors: the opioid receptor homodimers. | Q44340332 | ||
| C5a receptor oligomerization. I. Disulfide trapping reveals oligomers and potential contact surfaces in a G protein-coupled receptor | Q44497618 | ||
| Trans-activation of mutant follicle-stimulating hormone receptors selectively generates only one of two hormone signals | Q44730603 | ||
| Ligand-induced rearrangement of the dimeric metabotropic glutamate receptor 1alpha. | Q44927471 | ||
| Cooperative conformational changes in a G-protein-coupled receptor dimer, the leukotriene B(4) receptor BLT1. | Q45052891 | ||
| A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface | Q47412010 | ||
| Contribution of Serine Residues to Constitutive and Agonist-Induced Signaling via the D2SDopamine Receptor: Evidence for Multiple, Agonist-Specific Active Conformations | Q47752659 | ||
| P433 | issue | 48 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | G protein-coupled receptor | Q38173 |
| transmembrane protein | Q424204 | ||
| P304 | page(s) | 17495-17500 | |
| P577 | publication date | 2005-11-21 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation | |
| P478 | volume | 102 |
| Q42257101 | A Molecular Basis for Selective Antagonist Destabilization of Dopamine D3 Receptor Quaternary Organization. |
| Q36983708 | A day in the life of a G protein-coupled receptor: the contribution to function of G protein-coupled receptor dimerization |
| Q45951012 | A highly conserved tryptophan residue in the fourth transmembrane domain of the A adenosine receptor is essential for ligand binding but not receptor homodimerization. |
| Q30364526 | Activation of G protein-coupled receptors: beyond two-state models and tertiary conformational changes. |
| Q24315105 | Adenosine A(2A) receptors assemble into higher-order oligomers at the plasma membrane |
| Q41199385 | Adenosine A2a receptors form distinct oligomers in protein detergent complexes |
| Q37578268 | Advances in the Development and Application of Computational Methodologies for Structural Modeling of G-Protein Coupled Receptors. |
| Q39817865 | Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation. |
| Q38614218 | Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer. |
| Q38208847 | Allosteric modulation of protein oligomerization: an emerging approach to drug design |
| Q24633877 | Allostery at G Protein-Coupled Receptor Homo- and Heteromers: Uncharted Pharmacological Landscapes |
| Q47095739 | An engineered opsin monomer scrambles phospholipids. |
| Q40990314 | Analysis of Human Dopamine D3 Receptor Quaternary Structure |
| Q35719941 | Apo-Ghrelin Receptor Forms Heteromers with DRD2 in Hypothalamic Neurons and Is Essential for Anorexigenic Effects of DRD2 Agonism |
| Q51250449 | Beta2-adrenergic receptor homodimers: Role of transmembrane domain 1 and helix 8 in dimerization and cell surface expression |
| Q38155468 | Beyond standard molecular dynamics: investigating the molecular mechanisms of G protein-coupled receptors with enhanced molecular dynamics methods. |
| Q48104652 | Capturing the multiscale dynamics of membrane protein complexes with all-atom, mixed-resolution, and coarse-grained models |
| Q39944513 | Cell surface delivery and structural re-organization by pharmacological chaperones of an oligomerization-defective alpha(1b)-adrenoceptor mutant demonstrates membrane targeting of GPCR oligomers |
| Q37354853 | Complement factor 5a receptor chimeras reveal the importance of lipid-facing residues in transport competence |
| Q30528935 | Complex patterns of divergence among green-sensitive (RH2a) African cichlid opsins revealed by Clade model analyses |
| Q27001137 | Computational approaches for modeling GPCR dimerization |
| Q35594835 | Computational methods in drug design: modeling G protein-coupled receptor monomers, dimers, and oligomers |
| Q36329546 | Conformational changes involved in G-protein-coupled-receptor activation |
| Q40025475 | Conformational cross-talk between alpha2A-adrenergic and mu-opioid receptors controls cell signaling |
| Q88085556 | CrossTalk opposing view: Weighing the evidence for class A GPCR dimers, the jury is still out |
| Q27676608 | Crystal structure of oligomeric β1-adrenergic G protein–coupled receptors in ligand-free basal state |
| Q35879672 | Dimerization of the class A G protein-coupled neurotensin receptor NTS1 alters G protein interaction |
| Q41420661 | Dimerization of the lutropin receptor: insights from computational modeling. |
| Q37684117 | Dimers of G-protein coupled receptors as versatile storage and response units |
| Q30358822 | Divergent positive selection in rhodopsin from lake and riverine cichlid fishes. |
| Q34540985 | Docking studies of agonists and antagonists suggest an activation pathway of the A3 adenosine receptor |
| Q34561020 | Docking-based virtual screening for ligands of G protein-coupled receptors: not only crystal structures but also in silico models. |
| Q24318766 | Dopamine D2 receptors form higher order oligomers at physiological expression levels |
| Q36182026 | Dynamic Cholesterol-Conditioned Dimerization of the G Protein Coupled Chemokine Receptor Type 4. |
| Q34522194 | Dynamic Regulation of Quaternary Organization of the M1 Muscarinic Receptor by Subtype-selective Antagonist Drugs. |
| Q33825866 | Dynamic models of G-protein coupled receptor dimers: indications of asymmetry in the rhodopsin dimer from molecular dynamics simulations in a POPC bilayer. |
| Q55195798 | Dynamic tuneable G protein-coupled receptor monomer-dimer populations. |
| Q35695626 | Ecological and Lineage-Specific Factors Drive the Molecular Evolution of Rhodopsin in Cichlid Fishes. |
| Q24337429 | Emerging roles for the FSH receptor adapter protein APPL1 and overlap of a putative 14-3-3τ interaction domain with a canonical G-protein interaction site |
| Q52338934 | Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase |
| Q42936926 | Family a GPCR heteromers in animal models |
| Q34345068 | Fluorescent protein complementation assays: new tools to study G protein-coupled receptor oligomerization and GPCR-mediated signaling. |
| Q22242288 | Functional Selectivity and Classical Concepts of Quantitative Pharmacology |
| Q35104255 | Functional and structural characterization of rhodopsin oligomers |
| Q30009384 | Functional characterization of G-protein-coupled receptors: a bioinformatics approach |
| Q39839857 | Functional rescue of beta-adrenoceptor dimerization and trafficking by pharmacological chaperones |
| Q38118062 | Functional significance of serotonin receptor dimerization |
| Q30385233 | G Protein-Coupled Receptor Heterocomplexes in Neuropsychiatric Disorders |
| Q37421818 | G protein-coupled receptor hetero-dimerization: contribution to pharmacology and function |
| Q57781319 | G protein-coupled receptor oligomerization for what? |
| Q36941983 | G protein-coupled receptor oligomerization provides the framework for signal discrimination |
| Q37680849 | G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives |
| Q37829756 | G protein-coupled receptors: walking hand-in-hand, talking hand-in-hand? |
| Q34555671 | G-Protein Coupled Receptor 83 (GPR83) Signaling Determined by Constitutive and Zinc(II)-Induced Activity |
| Q37995726 | G-protein-coupled receptor dynamics: dimerization and activation models compared with experiment. |
| Q37058647 | GPCR monomers and oligomers: it takes all kinds |
| Q21198901 | GPCR oligomers in pharmacology and signaling |
| Q34454930 | Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery. |
| Q48048633 | HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. |
| Q37431503 | Hetero-oligomerization of CCR2, CCR5, and CXCR4 and the protean effects of "selective" antagonists. |
| Q38028547 | Heterodimerisation of G protein-coupled receptors: implications for drug design and ligand screening |
| Q37685668 | Heterodimerization of dopamine receptors: new insights into functional and therapeutic significance |
| Q35167034 | Heteromerization of human cytomegalovirus encoded chemokine receptors |
| Q46095475 | Identification of residues involved in homodimer formation located within a β-strand region of the N-terminus of a Yeast G protein-coupled receptor |
| Q37438039 | Identification of specific transmembrane residues and ligand-induced interface changes involved in homo-dimer formation of a yeast G protein-coupled receptor |
| Q24594672 | Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function |
| Q35758543 | Identifying a Neuromedin U Receptor 2 Splice Variant and Determining Its Roles in the Regulation of Signaling and Tumorigenesis In Vitro |
| Q36222134 | Impact of Lipid Composition and Receptor Conformation on the Spatio-temporal Organization of μ-Opioid Receptors in a Multi-component Plasma Membrane Model |
| Q34079450 | Importance of lipid-exposed residues in transmembrane segment four for family B calcitonin receptor homo-dimerization |
| Q35057759 | In silico analysis of the binding of agonists and blockers to the β2-adrenergic receptor. |
| Q36606981 | Inactive and active states and supramolecular organization of GPCRs: insights from computational modeling |
| Q33767121 | Increasingly accurate dynamic molecular models of G-protein coupled receptor oligomers: Panacea or Pandora's box for novel drug discovery? |
| Q41470212 | Influence of oligomerization on the dynamics of G-protein coupled receptors as assessed by normal mode analysis |
| Q50993982 | Inhibition of melanocortin-4 receptor dimerization by substitutions in intracellular loop 2 |
| Q36218464 | Insights into Basal Signaling Regulation, Oligomerization, and Structural Organization of the Human G-Protein Coupled Receptor 83. |
| Q39875146 | Instability of a class a G protein-coupled receptor oligomer interface |
| Q34094605 | Interactions between intracellular domains as key determinants of the quaternary structure and function of receptor heteromers |
| Q40245326 | Intra- or intercomplex binding to the gamma-secretase enzyme. A model to differentiate inhibitor classes |
| Q36770547 | Intramolecular allosteric communication in dopamine D2 receptor revealed by evolutionary amino acid covariation |
| Q41767833 | Lessons from free energy simulations of delta-opioid receptor homodimers involving the fourth transmembrane helix |
| Q36503035 | Ligand sensitivity in dimeric associations of the serotonin 5HT2c receptor |
| Q34244869 | Ligand-dependent conformations and dynamics of the serotonin 5-HT(2A) receptor determine its activation and membrane-driven oligomerization properties |
| Q41823093 | Ligand-regulated oligomerization of beta(2)-adrenoceptors in a model lipid bilayer |
| Q38338198 | Light on the structure of thromboxane A₂receptor heterodimers. |
| Q41694901 | Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer. |
| Q34160481 | Making structural sense of dimerization interfaces of delta opioid receptor homodimers |
| Q35879995 | Mapping Human Protease-activated Receptor 4 (PAR4) Homodimer Interface to Transmembrane Helix 4 |
| Q64898242 | Mapping the Interface of a GPCR Dimer: A Structural Model of the A2A Adenosine and D2 Dopamine Receptor Heteromer. |
| Q34420222 | Mechanism of activation of protein kinase JAK2 by the growth hormone receptor |
| Q30549886 | Membrane driven spatial organization of GPCRs |
| Q28072820 | Membrane-Mediated Oligomerization of G Protein Coupled Receptors and Its Implications for GPCR Function |
| Q33647180 | Modeling activated states of GPCRs: the rhodopsin template |
| Q51891051 | Modeling dimerizations of transmembrane proteins using Brownian dynamics simulations |
| Q36494771 | Mutations affecting the oligomerization interface of G-protein-coupled receptors revealed by a novel de novo protein design framework |
| Q35604455 | Mutually opposite signal modulation by hypothalamic heterodimerization of ghrelin and melanocortin-3 receptors |
| Q33736493 | Not just an oil slick: how the energetics of protein-membrane interactions impacts the function and organization of transmembrane proteins. |
| Q37203610 | Novel Insights on Thyroid-Stimulating Hormone Receptor Signal Transduction |
| Q36605553 | Oligomeric structure of the alpha1b-adrenoceptor: comparisons with rhodopsin |
| Q26752261 | Oligomerization of GPCRs involved in endocrine regulation |
| Q35288129 | Oligomerization of neuropeptide Y (NPY) Y2 receptors in CHO cells depends on functional pertussis toxin-sensitive G-proteins |
| Q27002925 | Opioid receptors: toward separation of analgesic from undesirable effects |
| Q34480194 | Opsin is present as dimers in COS1 cells: identification of amino acids at the dimeric interface |
| Q95641949 | Orexin/Hypocretin Type 2 Receptor (HCRTR2) Gene as a Candidate Gene in Sertraline-Associated Insomnia in Depressed Patients |
| Q34201750 | Palmitoylation and membrane cholesterol stabilize μ-opioid receptor homodimerization and G protein coupling. |
| Q51797175 | Partial agonist actions of aripiprazole and the candidate antipsychotics S33592, bifeprunox, N-desmethylclozapine and preclamol at dopamine D(2L) receptors are modified by co-transfection of D(3) receptors: potential role of heterodimer formation |
| Q35095066 | Progress in elucidating the structural and dynamic character of G Protein-Coupled Receptor oligomers for use in drug discovery |
| Q35512850 | Quantitative Modeling of Membrane Deformations by Multihelical Membrane Proteins: Application to G-Protein Coupled Receptors |
| Q37858664 | Recent progress in the study of G protein-coupled receptors with molecular dynamics computer simulations |
| Q38925254 | Regulation, Signaling, and Physiological Functions of G-Proteins |
| Q33286209 | Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base |
| Q33569254 | Rhodopsin and the others: a historical perspective on structural studies of G protein-coupled receptors |
| Q34480207 | Rhodopsin self-associates in asolectin liposomes |
| Q40132154 | Serotonin 5-HT(2C) receptor homodimerization is not regulated by agonist or inverse agonist treatment |
| Q40253042 | Serotonin 5-HT2C receptor homodimer biogenesis in the endoplasmic reticulum: real-time visualization with confocal fluorescence resonance energy transfer |
| Q92650126 | Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective |
| Q47651339 | Spatial Intensity Distribution Analysis: Studies of G Protein-Coupled Receptor Oligomerisation |
| Q35150277 | Structural Basis of M3 Muscarinic Receptor Dimer/Oligomer Formation |
| Q35790289 | Structural aspects of M₃ muscarinic acetylcholine receptor dimer formation and activation |
| Q36120778 | Structural determinants of the supramolecular organization of G protein-coupled receptors in bilayers. |
| Q37455434 | Structural determinants underlying constitutive dimerization of unoccupied human follitropin receptors |
| Q30401802 | Structural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at Work |
| Q38292961 | Structure and function of G protein-coupled receptor oligomers: implications for drug discovery |
| Q30576993 | Structure-function of the G protein-coupled receptor superfamily |
| Q47425376 | The Class-A GPCR Dopamine D2 Receptor Forms Transient Dimers Stabilized by Agonists: Detection by Single-Molecule Tracking |
| Q56963459 | The Heptahelical Domain of the Sweet Taste Receptor T1R2 Is a New Allosteric Binding Site for the Sweet Taste Modulator Amiloride That Modulates Sweet Taste in a Species-Dependent Manner |
| Q24628661 | The impact of GPCR structures on pharmacology and structure-based drug design |
| Q39255100 | The melanocortin 4 receptor: Oligomer formation, interaction sites and functional significance |
| Q34818743 | Towards a quantitative representation of the cell signaling mechanisms of hallucinogens: measurement and mathematical modeling of 5-HT1A and 5-HT2A receptor-mediated ERK1/2 activation |
| Q30413870 | Transmembrane domain IV of the Gallus gallus VT2 vasotocin receptor is essential for forming a heterodimer with the corticotrophin releasing hormone receptor |
| Q30408234 | Transmembrane domains of attraction on the TSH receptor |
| Q36978929 | Transmembrane segment peptides can disrupt cholecystokinin receptor oligomerization without affecting receptor function |
| Q33348279 | Triplet puzzle: homologies of receptor heteromers |
| Q37967933 | Update 1 of: Computational Modeling Approaches to Structure–Function Analysis of G Protein-Coupled Receptors |
| Q36731889 | Visual rhodopsin sees the light: structure and mechanism of G protein signaling |
| Q28591542 | mu opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis |
Search more.