Mutually opposite signal modulation by hypothalamic heterodimerization of ghrelin and melanocortin-3 receptors

scientific article published on 22 September 2011

Mutually opposite signal modulation by hypothalamic heterodimerization of ghrelin and melanocortin-3 receptors is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M111.287607
P932PMC publication ID3234785
P698PubMed publication ID21940628

P50authorMatthias TschöpQ21062625
Chun-Xia YiQ64218626
P2093author name stringAnnette Grüters
Gunnar Kleinau
Heike Biebermann
Heiko Krude
Torsten Schöneberg
Patrick Tarnow
Anne Rediger
Carolin L Piechowski
Rainer Strotmann
P2860cites workThe orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerizationQ24293767
Ghrelin controls hippocampal spine synapse density and memory performanceQ24305238
Ghrelin--a novel generation of anti-obesity drug: design, pharmacomodulation and biological activity of ghrelin analoguesQ37605059
Dimerization in GPCR mobility and signalingQ37632061
GOAT: the master switch for the ghrelin system?Q37737473
Homology modeling of G-protein-coupled receptors with X-ray structures on the riseQ37742542
In vivo characterization of high Basal signaling from the ghrelin receptorQ39788843
Conformational cross-talk between alpha2A-adrenergic and mu-opioid receptors controls cell signalingQ40025475
Activation of a dimeric metabotropic glutamate receptor by intersubunit rearrangement.Q40081094
Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humansQ40177137
MC4R oligomerizes independently of extracellular cysteine residuesQ40350941
Novel 3D pharmacophore of alpha-MSH/gamma-MSH hybrids leads to selective human MC1R and MC3R analoguesQ40446007
The regulation of food intake by selective stimulation of the type 3 melanocortin receptor (MC3R).Q40457702
Asymmetric conformational changes in a GPCR dimer controlled by G-proteins.Q41093303
From molecular details of the interplay between transmembrane helices of the thyrotropin receptor to general aspects of signal transduction in family a G-protein-coupled receptors (GPCRs).Q41883243
Molecular and structural effects of inverse agonistic mutations on signaling of the thyrotropin receptor--a basally active GPCR.Q42443005
Potent and selective agonism of the melanocortin receptor 4 with MK-0493 does not induce weight loss in obese human subjects: energy intake predicts lack of weight loss efficacyQ43278795
Effects of Ile164 polymorphism of beta2-adrenergic receptor gene on coronary artery disease.Q44088294
Ghrelin-induced food intake and growth hormone secretion are altered in melanocortin 3 and 4 receptor knockout miceQ80350255
A heterozygous mutation in the third transmembrane domain causes a dominant-negative effect on signalling capability of the MC4RQ82418956
Loss of constitutive activity of the growth hormone secretagogue receptor in familial short statureQ24306403
Ghrelin receptor mutations--too little height and too much hungerQ24541531
Airway smooth muscle prostaglandin-EP1 receptors directly modulate beta2-adrenergic receptors within a unique heterodimeric complexQ24545426
The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic systemQ24648633
Identification of a serotonin/glutamate receptor complex implicated in psychosisQ24655484
Crystal structure of a photoactivated deprotonated intermediate of rhodopsinQ24671760
Crystal structure of the ligand-free G-protein-coupled receptor opsinQ27650885
Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reactionQ27860958
Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and functionQ27919659
High constitutive signaling of the ghrelin receptor--identification of a potent inverse agonistQ28156211
Inactivation and intracellular retention of the human I183N mutated melanocortin 3 receptor associated with obesityQ28273968
Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activationQ28275509
The melanocortin-3 receptor is required for entrainment to meal intakeQ28594644
The druggable genomeQ29547361
A cDNA cloning vector that permits expression of cDNA inserts in mammalian cellsQ29614815
The structure and function of G-protein-coupled receptorsQ29616792
Ghrelin induces adiposity in rodentsQ29619226
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleusQ29619635
Ghrelin receptor gene: identification of several sequence variants in extremely obese children and adolescents, healthy normal-weight and underweight students, and children with short normal statureQ31035252
Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular modelsQ33503642
Heterodimerization of hypothalamic G-protein-coupled receptors involved in weight regulation.Q33522369
Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice.Q33841793
Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activationQ34142522
Oligomerization of G-protein-coupled transmitter receptors.Q34205602
Anatomy and regulation of the central melanocortin systemQ34414149
Receptor heterodimerization: a new level of cross-talkQ34576618
Exploring a role for heteromerization in GPCR signalling specificityQ34660378
G-protein-coupled receptor oligomerization and its potential for drug discoveryQ34932201
Heterodimerization of the alpha and beta isoforms of the human thromboxane receptor enhances isoprostane signalingQ35579014
Isoforms of mammalian adenylyl cyclase: multiplicities of signalingQ35679436
Constitutive ghrelin receptor activity as a signaling set-point in appetite regulationQ35731265
Mutant G-protein-coupled receptors as a cause of human diseasesQ35958795
The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology.Q36003378
GOAT links dietary lipids with the endocrine control of energy balanceQ37463007
Lean mean fat reducing "ghrelin" machine: hypothalamic ghrelin and ghrelin receptors as therapeutic targets in obesityQ37539098
P433issue45
P407language of work or nameEnglishQ1860
P921main subjectprotein heterodimerization activityQ14762999
P1104number of pages9
P304page(s)39623-39631
P577publication date2011-09-22
P1433published inJournal of Biological ChemistryQ867727
P1476titleMutually opposite signal modulation by hypothalamic heterodimerization of ghrelin and melanocortin-3 receptors
P478volume286

Reverse relations

cites work (P2860)
Q36439432Acylation type determines ghrelin's effects on energy homeostasis in rodents
Q34055216Apo-Ghrelin Receptor (apo-GHSR1a) Regulates Dopamine Signaling in the Brain
Q34551646Assessing interactions between Ghsr and Mc3r reveals a role for AgRP in the expression of food anticipatory activity in male mice
Q37403334Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors
Q39250251Clarifying the Ghrelin System's Ability to Regulate Feeding Behaviours Despite Enigmatic Spatial Separation of the GHSR and Its Endogenous Ligand
Q36013455Constitutive and ghrelin-dependent GHSR1a activation impairs CaV2.1 and CaV2.2 currents in hypothalamic neurons
Q47443295Desacyl Ghrelin Decreases Anxiety-like Behavior in Male Mice
Q51738222Dimerization of melanocortin receptor 1 (MC1R) and MC5R creates a ligand-dependent signal modulation: Potential participation in physiological color change in the flounder
Q47445733Epistatic effects between pairs of the growth hormone secretagogue receptor 1a, growth hormone, growth hormone receptor, non-SMC condensin I complex, subunit G and stearoyl-CoA desaturase genes on carcass, price-related and fatty acid composition tr
Q48195049Expression of the ghrelin receptor gene in neurons of the medulla oblongata of the rat
Q37690695From Belly to Brain: Targeting the Ghrelin Receptor in Appetite and Food Intake Regulation
Q38113559GHS-R1a constitutive activity and its physiological relevance
Q34962059GPCR Heterodimerization in the Reproductive System: Functional Regulation and Implication for Biodiversity
Q48112232Ghrelin Causes a Decline in GABA Release by Reducing Fatty Acid Oxidation in Cortex.
Q37019237Ghrelin Receptors in Non-Mammalian Vertebrates
Q64916449Ghrelin Through GHSR1a and OX1R Heterodimers Reveals a Gαs-cAMP-cAMP Response Element Binding Protein Signaling Pathway in Vitro.
Q37275590Ghrelin signalling on food reward: a salient link between the gut and the mesolimbic system
Q26783258Growth Hormone Secretagogue Receptor Dimers: A New Pharmacological Target(1,2,3)
Q46082980Hippocampus ghrelin receptor signaling promotes socially-mediated learned food preference
Q33689876Hormones and Neuropeptide Receptor Heteromers in the Ventral Tegmental Area. Targets for the Treatment of Loss of Control of Food Intake and Substance Use Disorders
Q36108397Hyperactive hypothalamus, motivated and non-distractible chronic overeating in ADAR2 transgenic mice
Q46550812Identification, tissue distribution and functional characterization of the ghrelin receptor in West African lungfish, Protopterus annectens
Q36308369Is Ghrelin Synthesized in the Central Nervous System?
Q37983474MC4R Dimerization in the Paraventricular Nucleus and GHSR/MC3R Heterodimerization in the Arcuate Nucleus: Is There Relevance for Body Weight Regulation?
Q33782186Melanocortin-3 Receptors and Metabolic Homeostasis
Q37284868Neural melanocortin receptors in obesity and related metabolic disorders
Q34079630Neuroanatomical characterization of a growth hormone secretagogue receptor-green fluorescent protein reporter mouse
Q37203610Novel Insights on Thyroid-Stimulating Hormone Receptor Signal Transduction
Q34290268Olfaction under metabolic influences.
Q26752261Oligomerization of GPCRs involved in endocrine regulation
Q50202446Orexin A/Hypocretin Modulates Leptin Receptor-Mediated Signaling by Allosteric Modulations Mediated by the Ghrelin GHS-R1A Receptor in Hypothalamic Neurons.
Q47366066Orphan neuropeptides and receptors: Novel therapeutic targets
Q39518263Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling
Q36109990Ring Finger Protein 11 Inhibits Melanocortin 3 and 4 Receptor Signaling
Q37393063Structure and physiological actions of ghrelin
Q86186199Structure-activity relationships of peptides incorporating a bioactive reverse-turn heterocycle at the melanocortin receptors: identification of a 5800-fold mouse melanocortin-3 receptor (mMC3R) selective antagonist/partial agonist versus the mouse
Q37132463Taking two to tango: a role for ghrelin receptor heterodimerization in stress and reward
Q51733160The Trace Amine-Associated Receptor 1 Agonist 3-Iodothyronamine Induces Biased Signaling at the Serotonin 1b Receptor
Q24568026The growth hormone secretagogue receptor: its intracellular signaling and regulation
Q30418283The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms
Q38222872The role of ghrelin in neuroprotection after ischemic brain injury.
Q36776721α₁A-adrenergic receptors regulate cardiac hypertrophy in vivo through interleukin-6 secretion

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