Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models

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Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models is …
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scholarly articleQ13442814

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P819ADS bibcode2009PLoSO...4.7011W
P356DOI10.1371/JOURNAL.PONE.0007011
P932PMC publication ID2738427
P698PubMed publication ID19756152
P5875ResearchGate publication ID26813963

P50authorCatherine Louise WorthQ54807453
P2093author name stringGunnar Kleinau
Gerd Krause
P2860cites workIdentification of the platelet ADP receptor targeted by antithrombotic drugsQ24290845
Activating Smoothened mutations in sporadic basal-cell carcinomaQ24318403
The Protein Data BankQ24515306
Shared and distinct genetic variants in type 1 diabetes and celiac diseaseQ24623113
Genetic variants in AVPR1A linked to autism predict amygdala activation and personality traits in healthy humansQ24644184
Identification of two distinct inactive conformations of the beta2-adrenergic receptor reconciles structural and biochemical observationsQ24645752
The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonistQ24654563
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptorQ24657484
Crystal structure of a photoactivated deprotonated intermediate of rhodopsinQ24671760
GPCRDB information system for G protein-coupled receptorsQ24681765
Crystal structure of rhodopsin: A G protein-coupled receptorQ27625972
The evolution of transmembrane helix kinks and the structural diversity of G protein-coupled receptorsQ27642987
Loops In Proteins (LIP)--a comprehensive loop database for homology modelling.Q51020128
Key issues in the computational simulation of GPCR function: representation of loop domains.Q52013586
A chorionic gonadotropin-sensitive mutation in the follicle-stimulating hormone receptor as a cause of familial gestational spontaneous ovarian hyperstimulation syndromeQ55671001
Rapid comparison of protein structuresQ56287146
Genetic Variations at the Endocannabinoid Type 1 Receptor Gene (CNR1) Are Associated with Obesity Phenotypes in MenQ57611825
Performance evaluation of amino acid substitution matricesQ72589783
Three novel rhodopsin mutations (C110F, L131P, A164V) in patients with autosomal dominant retinitis pigmentosaQ72860607
Leydig-cell tumors caused by an activating mutation of the gene encoding the luteinizing hormone receptorQ73223928
Molecular and conformational features of a transport-relevant domain in the C-terminal tail of the vasopressin V(2) receptorQ73387107
Understanding the structural and functional differences between mouse thyrotropin-releasing hormone receptors 1 and 2Q81544592
A heterozygous mutation in the third transmembrane domain causes a dominant-negative effect on signalling capability of the MC4RQ82418956
GRIS: glycoprotein-hormone receptor information systemQ82858423
Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and miceQ37257652
Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008.Q37309553
Activating mutations of the TSH receptor in differentiated thyroid carcinomas.Q38289568
Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomasQ38315242
Poor Cell Surface Expression of Human Melanocortin-4 Receptor Mutations Associated with ObesityQ38355676
Amino-Terminal Substitutions in the CCR5 Coreceptor Impair gp120 Binding and Human Immunodeficiency Virus Type 1 EntryQ38977702
Agonist-induced conformational changes in bovine rhodopsin: insight into activation of G-protein-coupled receptorsQ40069103
Adaptation to blockade of human immunodeficiency virus type 1 entry imposed by the anti-CCR5 monoclonal antibody 2D7.Q40782864
Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor functionQ40964911
Molecular and structural effects of inverse agonistic mutations on signaling of the thyrotropin receptor--a basally active GPCR.Q42443005
Contacts between extracellular loop two and transmembrane helix six determine basal activity of the thyroid-stimulating hormone receptorQ42503570
Implications for molecular mechanisms of glycoprotein hormone receptors using a new sequence-structure-function analysis resourceQ42504230
Revisiting automated G-protein coupled receptor modeling: the benefit of additional template structures for a neurokinin-1 receptor modelQ42618920
Structural mimicry of proline kinks: tertiary packing interactions support local structural distortions.Q44040777
The repertoire of G-protein-coupled receptors in fully sequenced genomesQ44163792
Structural determinants for selective recognition of peptide ligands for endothelin receptor subtypes ETA and ETB.Q44376726
The third extracellular loop of G-protein-coupled receptors: more than just a linker between two important transmembrane helices.Q45126281
Dimorphism in the P2Y1 ADP receptor gene is associated with increased platelet activation response to ADP.Q45130046
Ovarian hyperstimulation syndrome due to a mutation in the follicle-stimulating hormone receptor.Q45233493
An indel in transmembrane helix 2 helps to trace the molecular evolution of class A G-protein-coupled receptorsQ46055678
Structure of the third intracellular loop of the vasopressin V2 receptor and conformational changes upon binding to gC1qR.Q46088781
Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eatingQ46249432
Characterization of determinants of ligand binding to the nicotinic acid receptor GPR109A (HM74A/PUMA-G).Q46649975
Molecular analysis of beta(2)-adrenoceptor coupling to G(s)-, G(i)-, and G(q)-proteins.Q46895130
Mutationally Induced Disulfide Bond Formation within the Third Extracellular Loop Causes Melanocortin 4 Receptor Inactivation in Patients with ObesityQ47611984
Acquired ocular visual impairment in children. 1960-1989.Q48324275
Cannabinoid receptor type 2 gene is associated with human osteoporosis.Q48744794
Crystal Structure of a Thermally Stable Rhodopsin MutantQ27647947
Crystal structure of the human beta2 adrenergic G-protein-coupled receptorQ27648868
Crystal Structure of Squid Rhodopsin with Intracellularly Extended Cytoplasmic RegionQ27650564
Crystal structure of squid rhodopsinQ27650621
Crystal structure of the ligand-free G-protein-coupled receptor opsinQ27650885
Structure of a beta1-adrenergic G-protein-coupled receptorQ27651011
Crystal structure of opsin in its G-protein-interacting conformationQ27652301
Clustal W and Clustal X version 2.0Q27860517
Rhodopsin mutation G90D and a molecular mechanism for congenital night blindnessQ28116173
Molecular identification of the gene responsible for congenital nephrogenic diabetes insipidusQ28183211
Improved yield of a ligand-binding GPCR expressed in E. coli for structural studiesQ28299376
High-level production, solubilization and purification of synthetic human GPCR chemokine receptors CCR5, CCR3, CXCR4 and CX3CR1Q28474776
The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprintsQ29547321
The druggable genomeQ29547361
The structure and function of G-protein-coupled receptorsQ29616792
The universal protein resource (UniProt)Q29617074
JOY: protein sequence-structure representation and analysis.Q30431389
Drug design strategies for targeting G-protein-coupled receptorsQ30859422
A supersecondary structure library and search algorithm for modeling loops in protein structuresQ33240022
Ligand and structure-based models for the prediction of ligand-receptor affinities and virtual screenings: Development and application to the beta(2)-adrenergic receptorQ33636089
Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptorQ33887729
Decreased muscarinic1 receptors in the dorsolateral prefrontal cortex of subjects with schizophreniaQ34163923
Constitutively active mutants of rhodopsinQ34244263
Activation of rhodopsin: new insights from structural and biochemical studiesQ34245445
Discovery of new GPCR biology: one receptor structure at a timeQ34920862
Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesityQ35126395
Heavier-than-air flying machines are impossible.Q35757370
Mutant G-protein-coupled receptors as a cause of human diseasesQ35958795
The role of internal water molecules in the structure and function of the rhodopsin family of G protein-coupled receptorsQ36685974
On the applicability of GPCR homology models to computer-aided drug discovery: a comparison between in silico and crystal structures of the beta2-adrenergic receptor.Q36744266
The Cys allele of the DRD2 Ser311Cys polymorphism has a dominant effect on risk for schizophrenia: evidence from fixed- and random-effects meta-analysesQ36940384
Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptorsQ37208884
Structural and kinetic modeling of an activating helix switch in the rhodopsin-transducin interfaceQ37250013
Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation.Q37250484
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectG protein-coupled receptorQ38173
crystal structureQ895901
P304page(s)e7011
P577publication date2009-09-16
P1433published inPLOS OneQ564954
P1476titleComparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models
P478volume4