| scholarly article | Q13442814 |
| P356 | DOI | 10.1002/1439-7633(20021004)3:10<928::AID-CBIC928>3.0.CO;2-5 |
| P698 | PubMed publication ID | 12362358 |
| P2093 | author name string | Gerhard Hessler | |
| Thomas Klabunde | |||
| P2860 | cites work | RECAPRetrosynthetic Combinatorial Analysis Procedure: A Powerful New Technique for Identifying Privileged Molecular Fragments with Useful Applications in Combinatorial Chemistry | Q32062075 |
| Involvement of Asn-293 in stereospecific agonist recognition and in activation of the beta 2-adrenergic receptor | Q37392202 | ||
| Molecular modeling studies of human A3 adenosine antagonists: structural homology and receptor docking | Q40989540 | ||
| P433 | issue | 10 | |
| P921 | main subject | G protein-coupled receptor | Q38173 |
| protein design | Q410814 | ||
| P304 | page(s) | 928-944 | |
| P577 | publication date | 2002-10-01 | |
| P13046 | publication type of scholarly work | review article | Q7318358 |
| P1433 | published in | ChemBioChem | Q634395 |
| P1476 | title | Drug design strategies for targeting G-protein-coupled receptors | |
| P478 | volume | 3 |
| Q38547704 | 3D Structural Models of Transmembrane Proteins |
| Q38223015 | 4-isoxazolyl-1,4-dihydropyridines: a tale of two scaffolds |
| Q55468262 | A Sequential Segment Based Alpha-Helical Transmembrane Protein Alignment Method. |
| Q81739859 | A hypothesis for GPCR activation |
| Q37034874 | A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism |
| Q44220386 | A methods‐based biotechnology course for undergraduates |
| Q33600355 | A novel chemogenomics analysis of G protein-coupled receptors (GPCRs) and their ligands: a potential strategy for receptor de-orphanization |
| Q28478109 | A novel structural framework for α(1A/D)-adrenoceptor selective antagonists identified using subtype selective pharmacophores |
| Q41082722 | A positive feedback-based gene circuit to increase the production of a membrane protein |
| Q53632809 | A two-entropies analysis to identify functional positions in the transmembrane region of class A G protein-coupled receptors |
| Q34985885 | An overview on GPCRs and drug discovery: structure-based drug design and structural biology on GPCRs |
| Q30163852 | Analysis of side-chain rotamers in transmembrane proteins |
| Q35735074 | Analysis of the Human Prostate-Specific Proteome Defined by Transcriptomics and Antibody-Based Profiling Identifies TMEM79 and ACOXL as Two Putative, Diagnostic Markers in Prostate Cancer |
| Q50437150 | Applications of yeast-based signaling sensor for characterization of antagonist and analysis of site-directed mutants of the human serotonin 1A receptor. |
| Q84705232 | CH/π hydrogen bonds play a role in ligand recognition and equilibrium between active and inactive states of the β2 adrenergic receptor: An ab initio fragment molecular orbital (FMO) study |
| Q45192871 | Chemical Genomics Approach for GPCR–Ligand Interaction Prediction and Extraction of Ligand Binding Determinants |
| Q33368550 | Chemical substructures that enrich for biological activity |
| Q28477082 | Chemogenomic Analysis of G-Protein Coupled Receptors and Their Ligands Deciphers Locks and Keys Governing Diverse Aspects of Signalling |
| Q36833536 | Chemogenomic approaches to rational drug design |
| Q37309553 | Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008. |
| Q40007908 | Comparative docking study of anibamine as the first natural product CCR5 antagonist in CCR5 homology models. |
| Q41161155 | Comparative domain modeling of human EGF-like module EMR2 and study of interaction of the fourth domain of EGF with chondroitin 4-sulphate |
| Q33503642 | Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models |
| Q51983899 | Comparing ligand interactions with multiple receptors via serial docking. |
| Q37022667 | Computational cell analysis for label-free detection of cell properties in a microfluidic laminar flow |
| Q33187540 | Computational design strategies for combinatorial libraries |
| Q51823568 | Computational study of the heterodimerization between mu and delta receptors |
| Q33415053 | Computing highly correlated positions using mutual information and graph theory for G protein-coupled receptors |
| Q35588397 | Conformational changes of G protein-coupled receptors during their activation by agonist binding |
| Q50469777 | Consequences of membrane protein overexpression in Escherichia coli. |
| Q46916180 | Conserved network properties of helical membrane protein structures and its implication for improving membrane protein homology modeling at the twilight zone |
| Q46597532 | Construction of Structural Mimetics of the Thyrotropin Receptor Intracellular Domain |
| Q34590730 | Coupling of retinal, protein, and water dynamics in squid rhodopsin. |
| Q41875668 | Cross-pharmacology analysis of G protein-coupled receptors |
| Q21563643 | DNA display II. Genetic manipulation of combinatorial chemistry libraries for small-molecule evolution |
| Q35424306 | Differential stimulation of insulin secretion by GLP-1 and Kisspeptin-10. |
| Q40257010 | Dimethylsulphoxide as a tool to increase functional expression of heterologously produced GPCRs in mammalian cells |
| Q34049826 | Do crystal structures obviate the need for theoretical models of GPCRs for structure-based virtual screening? |
| Q55341853 | Docking-based inverse virtual screening: methods, applications, and challenges. |
| Q35051379 | Drug activity prediction using multiple-instance learning via joint instance and feature selection |
| Q37143137 | Drugging Membrane Protein Interactions |
| Q49955340 | Dual-Color Bioluminescence Analysis for Quantitatively Monitoring G-Protein-Coupled Receptor and β-Arrestin Interactions. |
| Q46839257 | Employing Rhodobacter sphaeroides to functionally express and purify human G protein-coupled receptors. |
| Q36458321 | Enhancing functional production of G protein-coupled receptors in Pichia pastoris to levels required for structural studies via a single expression screen |
| Q33757270 | Evaluating docking methods for prediction of binding affinities of small molecules to the G protein betagamma subunits |
| Q39554621 | Evaluation of the Pichia pastoris expression system for the production of GPCRs for structural analysis |
| Q41860044 | Evolutionary analysis of rhodopsin and cone pigments: connecting the three-dimensional structure with spectral tuning and signal transfer |
| Q40023482 | Exosome nanovesicles displaying G protein-coupled receptors for drug discovery. |
| Q80814684 | Exploring structure-selectivity relationships of biogenic amine GPCR antagonists using similarity searching and dynamic compound mapping |
| Q28068743 | Food-Derived Natural Compounds for Pain Relief in Neuropathic Pain |
| Q41916230 | Fractal dimension as a measure of surface roughness of G protein-coupled receptors: implications for structure and function |
| Q57903757 | Functional analysis of cell-free-produced human endothelin B receptor reveals transmembrane segment 1 as an essential area for ET-1 binding and homodimer formation |
| Q34057150 | G protein-coupled receptor-associated sorting protein 1 regulates the postendocytic sorting of seven-transmembrane-spanning G protein-coupled receptors |
| Q37388375 | G protein-coupled receptors: in silico drug discovery in 3D. |
| Q36344531 | GLASS: a comprehensive database for experimentally validated GPCR-ligand associations |
| Q33213253 | GPCR antitarget modeling: pharmacophore models for biogenic amine binding GPCRs to avoid GPCR-mediated side effects |
| Q80113754 | GPCR-tailored pharmacophore pattern recognition of small molecular ligands |
| Q34389708 | GPCRDB: an information system for G protein-coupled receptors |
| Q24616648 | GPCRDB: information system for G protein-coupled receptors |
| Q33362167 | GPCRTree: online hierarchical classification of GPCR function |
| Q44157633 | Genomics spawns novel approaches to mosquito control |
| Q92237673 | Group I mGluR-Mediated Activation of Martinotti Cells Inhibits Local Cortical Circuitry in Human Cortex |
| Q80824997 | Heterologous expression and characterization of the recombinant bradykinin B2 receptor using the methylotrophic yeast Pichia pastoris |
| Q31063961 | High-throughput modeling of human G-protein coupled receptors: amino acid sequence alignment, three-dimensional model building, and receptor library screening |
| Q30884216 | Highly Sensitive Recognition of Substrates of Adrenergic Receptors at the Air/Water Interface |
| Q30365203 | Homology modeling and molecular docking of human pituitary adenylate cyclase‑activating polypeptide I receptor. |
| Q34651393 | Homology modeling of opioid receptor-ligand complexes using experimental constraints |
| Q35632512 | Human olfactory receptor responses to odorants. |
| Q39159119 | Hydration Site Thermodynamics Explain SARs for Triazolylpurines Analogues Binding to the A2A Receptor |
| Q36227916 | Implementation of multiple-instance learning in drug activity prediction. |
| Q84344311 | Improving transmembrane protein consensus topology prediction using inter-helical interaction |
| Q34658695 | In silico studies on DARC. |
| Q35853199 | Insights into the pharmacological relevance of lysophospholipid receptors |
| Q28475578 | Integrating statistical predictions and experimental verifications for enhancing protein-chemical interaction predictions in virtual screening |
| Q38777517 | Intensity interrogation near cutoff resonance for label-free cellular profiling. |
| Q46825061 | Interacting residues in an activated state of a G protein-coupled receptor |
| Q36295175 | Interaction of a fragment of the cannabinoid CB1 receptor C-terminus with arrestin-2. |
| Q31160779 | Internal hydration increases during activation of the G-protein-coupled receptor rhodopsin |
| Q37443837 | Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes |
| Q30873611 | Isotopic labeling of mammalian G protein-coupled receptors heterologously expressed in Caenorhabditis elegans |
| Q36294091 | Keynote review: in vitro safety pharmacology profiling: an essential tool for successful drug development |
| Q36943625 | Large-scale functional expression of WT and truncated human adenosine A2A receptor in Pichia pastoris bioreactor cultures |
| Q35015836 | Large-scale polymorphism discovery in macaque G-protein coupled receptors |
| Q33650270 | Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptors |
| Q64992482 | Ligand-based pharmacophore model for the discovery of novel CXCR2 antagonists as anti-cancer metastatic agents. |
| Q47396241 | Ligand-supported Homology Modelling of Protein Binding-sites using Knowledge-based Potentials |
| Q34145236 | Lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors |
| Q27692680 | Lysophospholipid receptors in drug discovery |
| Q37850440 | Macrocycles Are Great Cycles: Applications, Opportunities, and Challenges of Synthetic Macrocycles in Drug Discovery |
| Q35636536 | Matrix metalloproteinase inhibitor development and the remodeling of drug discovery |
| Q45945296 | MemBrain-contact 2.0: A new two-stage machine learning model for the prediction enhancement of transmembrane protein residue contacts in the full chain. |
| Q51239957 | Metal ion site engineering indicates a global toggle switch model for seven-transmembrane receptor activation |
| Q35980130 | Mining the receptorome |
| Q36868566 | Model structure-activity relationship studies of potential tropane 5HT1A, 5HT2A, and D2 receptor ligands. |
| Q39537387 | Modeling Complexes of Transmembrane Proteins: Systematic Analysis of ProteinProtein Docking Tools |
| Q33360557 | Modulating G-protein coupled receptor/G-protein signal transduction by small molecules suggested by virtual screening |
| Q40854828 | Molecular Modeling of Geometries, Charge Distributions, and Binding Energies of Small, Druglike Molecules Containing Nitrogen Heterocycles and Exocyclic Amino Groups in the Gas Phase and in Aqueous Solution |
| Q61758664 | Molecular biology in diagnostic histopathology. Part 3: signal transduction |
| Q46295772 | Molecular dynamics simulation of neuropeptide B and neuropeptide W in the dipalmitoylphosphatidylcholine membrane bilayer |
| Q46772861 | Molecular dynamics simulations of bovine rhodopsin: influence of protonation states and different membrane-mimicking environments |
| Q38710906 | Monitoring Cell-surface N-Glycoproteome Dynamics by Quantitative Proteomics Reveals Mechanistic Insights into Macrophage Differentiation. |
| Q47951568 | Monitoring Dynamic Changes of the Cell Surface Glycoproteome by Quantitative Proteomics. |
| Q27902288 | Multiple conformational states in retrospective virtual screening – homology models vs. crystal structures: beta-2 adrenergic receptor case study |
| Q47228770 | Multiple deletions reveal the essentiality of the DedA membrane protein family in Escherichia coli |
| Q35618019 | Multitarget-directed tricyclic pyridazinones as G protein-coupled receptor ligands and cholinesterase inhibitors |
| Q33244414 | N-ethyl-N-nitrosourea-based generation of mouse models for mutant G protein-coupled receptors |
| Q33793575 | NClassG+: A classifier for non-classically secreted Gram-positive bacterial proteins |
| Q36527741 | Neuropeptide Y and somatostatin inhibit insulin secretion through different mechanisms |
| Q35600016 | Neuropeptide gene polymorphisms and human behavioural disorders |
| Q42737102 | New opportunities to fight against infectious diseases and to identify pertinent drug targets with novel methodologies |
| Q91637800 | Ocular Albinism Type 1 Regulates Deltamethrin Tolerance in Lymantria dispar and Drosophila melanogaster |
| Q36744266 | On the applicability of GPCR homology models to computer-aided drug discovery: a comparison between in silico and crystal structures of the beta2-adrenergic receptor. |
| Q48378161 | On the hierarchical classification of G protein-coupled receptors |
| Q57012617 | On the origins of drug polypharmacology |
| Q37118663 | Opportunities and challenges in combination gene cancer therapy |
| Q58103252 | Optimization of spiroimidazolidinone derivatives synthesis on solid phase using SynPhase™ Lanterns |
| Q40281558 | Optimization of the human adenosine A2a receptor yields in Saccharomyces cerevisiae |
| Q39753263 | Overproduction of human M₃ muscarinic acetylcholine receptor: an approach toward structural studies |
| Q34147273 | Overview on the use of therapeutic antibodies in drug discovery |
| Q47382339 | PSOFuzzySVM-TMH: identification of transmembrane helix segments using ensemble feature space by incorporated fuzzy support vector machine |
| Q34571419 | Pathway-selective antagonism of proteinase activated receptor 2. |
| Q28709274 | Pharmacosynthetics: Reimagining the pharmacogenetic approach |
| Q36944236 | Potentials of phenolic molecules of natural origin and their derivatives as anti-HIV agents |
| Q33545205 | Predicting transmembrane helix packing arrangements using residue contacts and a force-directed algorithm |
| Q45952703 | Prediction of drug-target interaction by label propagation with mutual interaction information derived from heterogeneous network. |
| Q34811341 | Principal component analysis of binding energies for single-point mutants of hT2R16 bound to an agonist correlate with experimental mutant cell response |
| Q37274469 | Probing the role of the cation-pi interaction in the binding sites of GPCRs using unnatural amino acids. |
| Q33868233 | Production and partial purification of membrane proteins using a liposome-supplemented wheat cell-free translation system. |
| Q33369621 | ProteoLens: a visual analytic tool for multi-scale database-driven biological network data mining |
| Q36886048 | Proteomic applications of automated GPCR classification |
| Q52935238 | Putting small molecules in the lead |
| Q41980399 | Qualifying a eukaryotic cell-free system for fluorescence based GPCR analyses |
| Q33977964 | RETRACTED: 3-Benzhydryl-4-piperidones as novel neurokinin-1 receptor antagonists and their efficient synthesis |
| Q40165384 | Rational design, synthesis, biologic evaluation, and structure-activity relationship studies of novel 1-indanone alpha(1)-adrenoceptor antagonists |
| Q39371869 | Regulated Expression of pH Sensing G Protein-Coupled Receptor-68 Identified through Chemical Biology Defines a New Drug Target for Ischemic Heart Disease |
| Q39817839 | Regulation of p53 expression, phosphorylation and subcellular localization by a G-protein-coupled receptor. |
| Q33246297 | Representation of target-bound drugs by computed conformers: implications for conformational libraries |
| Q50750082 | Second annual GPCRs: from orphan to blockbuster |
| Q35081967 | Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin |
| Q37245459 | Signaling by G-protein-coupled receptor (GPCR): studies on the GnRH receptor |
| Q38128158 | Similarity-based machine learning methods for predicting drug-target interactions: a brief review |
| Q31113004 | Statistical prediction of protein chemical interactions based on chemical structure and mass spectrometry data |
| Q40457189 | Structural basis for a broad but selective ligand spectrum of a mouse olfactory receptor: mapping the odorant-binding site. |
| Q24595968 | Structure of the human histamine H1 receptor complex with doxepin |
| Q33736866 | Structure prediction of the second extracellular loop in G-protein-coupled receptors |
| Q30435017 | Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists |
| Q33444098 | Substructure mining of GPCR ligands reveals activity-class specific functional groups in an unbiased manner |
| Q30356936 | SuperBiHelix method for predicting the pleiotropic ensemble of G-protein-coupled receptor conformations. |
| Q46778801 | Synthesis and evaluation of some xanthone derivatives for anti-arrhythmic, hypotensive properties and their affinity for adrenergic receptors. |
| Q34402346 | Synthesis of Rhenium‐Centric Reverse Turn Mimics |
| Q86589783 | Synthesis of various secosteroidal macrocycles by ring-closing metathesis |
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| Q82543696 | Target Family-Directed Exploration of Scaffolds with Different SAR Profiles |
| Q26744191 | Tethered and Polymer Supported Bilayer Lipid Membranes: Structure and Function |
| Q33253601 | The 7 TM G-protein-coupled receptor target family |
| Q33373826 | The Adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury |
| Q84603072 | The Family of G Protein-Coupled Receptors: An Example of Membrane Proteins |
| Q33400100 | The G protein-coupled receptor subset of the dog genome is more similar to that in humans than rodents |
| Q39052399 | The Physiological Effects of Dandelion (Taraxacum Officinale) in Type 2 Diabetes |
| Q57955562 | The Structure of the Neuropeptide Bradykinin Bound to the Human G-Protein Coupled Receptor Bradykinin B2 as Determined by Solid-State NMR Spectroscopy |
| Q21283861 | The amphioxus (Branchiostoma floridae) genome contains a highly diversified set of G protein-coupled receptors |
| Q35977626 | The conformation of neurotensin bound to its G protein-coupled receptor |
| Q80095128 | The discovery of CCR5 receptor antagonists for the treatment of HIV infection: hit-to-lead studies |
| Q24292706 | The evolutionary history and tissue mapping of GPR123: specific CNS expression pattern predominantly in thalamic nuclei and regions containing large pyramidal cells |
| Q24297111 | The human and mouse repertoire of the adhesion family of G-protein-coupled receptors |
| Q37876534 | The structure of the adenosine receptors: implications for drug discovery. |
| Q33893103 | The use of G-protein coupled receptor models in lead optimization |
| Q27007472 | Tools for GPCR drug discovery |
| Q37306269 | Topology of class A G protein-coupled receptors: insights gained from crystal structures of rhodopsins, adrenergic and adenosine receptors |
| Q37269754 | Toward deciphering the code to aminergic G protein-coupled receptor drug design |
| Q39535940 | Towards the Next Generation of Computational Chemogenomics Tools |
| Q30352431 | Transmembrane Protein Alignment and Fold Recognition Based on Predicted Topology |
| Q30383769 | Unraveling the structure and function of G protein-coupled receptors through NMR spectroscopy. |
| Q37967933 | Update 1 of: Computational Modeling Approaches to Structure–Function Analysis of G Protein-Coupled Receptors |
| Q34225372 | Using Novel Descriptor Accounting for Ligand–Receptor Interactions To Define and Visually Explore Biologically Relevant Chemical Space |
| Q33640639 | Using ligand-based virtual screening to allosterically stabilize the activated state of a GPCR. |
| Q50332494 | Variable Dependence of Signaling Output on Agonist Occupancy of Ste2p, a G Protein-coupled Receptor in Yeast |
| Q43974711 | WRF-TMH: predicting transmembrane helix by fusing composition index and physicochemical properties of amino acids |
| Q33751353 | iPHACE: integrative navigation in pharmacological space |
| Q33989429 | ss-TEA: Entropy based identification of receptor specific ligand binding residues from a multiple sequence alignment of class A GPCRs |
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